Nanopharmaceuticals for Eye Administration: Sterilization, Depyrogenation and Clinical Applications

Zielińska, Aleksandra; Soles, Beatriz B; Lopes, Ana Rute Elias; Vaz, Beatriz F; Rodrigues, Camila M; Alves, Thaís Francine Ribeiro; Klensporf‐Pawlik, Dorota; Durazzo, Alessandra; Lucarini, Massimo; Severino, Patrícia; Santini, Antonello; Chaud, Marco V.; Souto, Eliana B.

doi:10.3390/biology9100336

Cited by 13 publications

(9 citation statements)

References 79 publications

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“… 226 For unstable nanoparticles, aseptic filtration is recommended. 227 High-pressure steam sterilization and ethylene oxide sterilization are not suitable for most drug delivery systems as the properties of DDSs and its loaded drugs would easy to be destroy. 227 However, there still are some formulations had been proved that their properties maintained their properties after autoclave.…”

Section: Discussionmentioning

confidence: 99%

Knee Osteoarthritis Therapy: Recent Advances in Intra-Articular Drug Delivery Systems

Ma¹,

Zheng²,

Li³

et al. 2022

DDDT

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Drug delivery for osteoarthritis (OA) treatment is a continuous challenge because of their poor bioavailability and rapid clearance in joints. Intra-articular (IA) drug delivery is a common strategy and its therapeutic effects depend mainly on the efficacy of the drug-delivery system used for OA therapy. Different types of IA drug-delivery systems, such as microspheres, nanoparticles, and hydrogels, have been rapidly developed over the past decade to improve their therapeutic effects. With the continuous advancement in OA mechanism research, new drugs targeting specific cell/signaling pathways in OA are rapidly evolving and effective drug delivery is critical for treating OA. In this review, recent advances in various IA drug-delivery systems for OA treatment, OA targeted strategies, and related signaling pathways in OA treatment are summarized and analyzed based on current publications.

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Section: Discussionmentioning

confidence: 99%

Knee Osteoarthritis Therapy: Recent Advances in Intra-Articular Drug Delivery Systems

Ma¹,

Zheng²,

Li³

et al. 2022

DDDT

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“…Krause et al performed an experiment in which it was demonstrated that, upon heat sterilization at 134 °C at 2 bar for 25 min, PAMAM dendrimers did not retain their structure, whereas the polypropylenimine and polylysine dendrimers remained structurally stable. Sterilization by conventional sterile filters under aseptic conditions is a potential workaround for this problem, allowing for the effective elimination of microorganisms from the formulation [ 176 ]. Another important issue is the examination of the potential presence of endotoxins, following the sterilization process [ 177 , 178 ].…”

Section: Future Prospects and Nanomedicine Regulatory Issuesmentioning

confidence: 99%

Recent Advances in Preclinical Research Using PAMAM Dendrimers for Cancer Gene Therapy

Tarach

Janaszewska

2021

IJMS

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Carriers of genetic material are divided into vectors of viral and non-viral origin. Viral carriers are already successfully used in experimental gene therapies, but despite advantages such as their high transfection efficiency and the wide knowledge of their practical potential, the remaining disadvantages, namely, their low capacity and complex manufacturing process, based on biological systems, are major limitations prior to their broad implementation in the clinical setting. The application of non-viral carriers in gene therapy is one of the available approaches. Poly(amidoamine) (PAMAM) dendrimers are repetitively branched, three-dimensional molecules, made of amide and amine subunits, possessing unique physiochemical properties. Surface and internal modifications improve their physicochemical properties, enabling the increase in cellular specificity and transfection efficiency and a reduction in cytotoxicity toward healthy cells. During the last 10 years of research on PAMAM dendrimers, three modification strategies have commonly been used: (1) surface modification with functional groups; (2) hybrid vector formation; (3) creation of supramolecular self-assemblies. This review describes and summarizes recent studies exploring the development of PAMAM dendrimers in anticancer gene therapies, evaluating the advantages and disadvantages of the modification approaches and the nanomedicine regulatory issues preventing their translation into the clinical setting, and highlighting important areas for further development and possible steps that seem promising in terms of development of PAMAM as a carrier of genetic material.

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“…The production takes place in a clean room. It is convenient to perform terminal sterilization rather than an aseptic production process [98,99].…”

Section: Strategies For Enhancing Ocular Drug Delivery Systemmentioning

confidence: 99%

Cellulosic Polymers for Enhancing Drug Bioavailability in Ocular Drug Delivery Systems

et al. 2021

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One of the major impediments to drug development is low aqueous solubility and thus poor bioavailability, which leads to insufficient clinical utility. Around 70–80% of drugs in the discovery pipeline are suffering from poor aqueous solubility and poor bioavailability, which is a major challenge when one has to develop an ocular drug delivery system. The outer lipid layer, pre-corneal, dynamic, and static ocular barriers limit drug availability to the targeted ocular tissues. Biopharmaceutical Classification System (BCS) class II drugs with adequate permeability and limited or no aqueous solubility have been extensively studied for various polymer-based solubility enhancement approaches. The hydrophilic nature of cellulosic polymers and their tunable properties make them the polymers of choice in various solubility-enhancement techniques. This review focuses on various cellulose derivatives, specifically, their role, current status and novel modified cellulosic polymers for enhancing the bioavailability of BCS class II drugs in ocular drug delivery systems.

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Nanopharmaceuticals for Eye Administration: Sterilization, Depyrogenation and Clinical Applications

Cited by 13 publications

References 79 publications

Knee Osteoarthritis Therapy: Recent Advances in Intra-Articular Drug Delivery Systems

Knee Osteoarthritis Therapy: Recent Advances in Intra-Articular Drug Delivery Systems

Recent Advances in Preclinical Research Using PAMAM Dendrimers for Cancer Gene Therapy

Cellulosic Polymers for Enhancing Drug Bioavailability in Ocular Drug Delivery Systems

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