Nanomedicine-based approaches for improved delivery of phyto-therapeutics for cancer therapy

Hafez, Dina A.; Elkhodairy, Kadria A.; Teleb, Mohamed; Elzoghby, Ahmed O.

doi:10.1080/17425247.2020.1723542

Cited by 24 publications

(4 citation statements)

References 36 publications

(43 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The pharmacokinetic results of the verapamil treated group and the PPR treated group are in close agreement, suggesting the effectiveness of PPR as Pgp inhibitor. DPD phytosomes have offered improved pharmacokinetics, augmented metabolic stability, amplified membrane permeability, and boosted bioavailability(Hafez et al, 2020).…”

mentioning

confidence: 99%

Piperine phytosomes for bioavailability enhancement of domperidone

Islam

Irfan

Hussain

et al. 2021

Journal of Liposome Research

View full text Add to dashboard Cite

The markedly low oral bioavailability of domperidone (anti-emetic drug) is associated with rapid first-pass metabolism in the intestine and liver. To counteract such affects, there is a need to devise a strategy to enhance absorption and subsequently bioavailability. Thus, the current study was aimed at synthesizing phytosomes consisting of phosphatidylcholine and piperine (a Pglycoprotein inhibitor). Phytosomes were prepared by salting-out method. The developed phytosomes were extensively characterized for size, zeta potential, polydispersity index, entrapment efficiency (EE %), infrared spectroscopy, X-ray diffraction, in-vitro drug release, exvivo permeation, in-vivo pharmacokinetic and toxicity. The engineered formulations of phytosomes with piperine exhibited a significant improvement in oral bioavailability of domperidone (79.5%) in comparison with the pure drug suspension under the same conditions. Pharmacokinetic parameters such as maximal plasma concentration (Cmax) and the plasma concentration (estimated from area under the curve; AUC) of domperidone have been greatly increased relative to drug alone. The improved drug absorption was attributed to inhibition of Pglycoprotein transporter. The findings of current research work suggest that the optimized phytosomes based drug delivery containing phytochemicals as bioenhancers have the potential to improve bioavailability of poorly bioavailable drugs that are substrate to P-glycoprotein.

show abstract

mentioning

confidence: 99%

Piperine phytosomes for bioavailability enhancement of domperidone

Islam

Irfan

Hussain

et al. 2021

Journal of Liposome Research

View full text Add to dashboard Cite

show abstract

“…The performance of these nanoformulations can be improved by modifying their composition, particle size and surface characteristics to increase their efficacy, reduce side effects and overcome drug resistance. It is expected that these phytochemicals incorporated into nanoformulations will have altered bioavailability, permeability and toxicity profiles and will have more efficacy in cancer therapy ( 28 , 29 ).…”

Section: Introductionmentioning

confidence: 99%

A spotlight on alkaloid nanoformulations for the treatment of lung cancer

Sindhoor¹,

Naveen²,

Rao

et al. 2022

Front. Oncol.

View full text Add to dashboard Cite

Numerous naturally available phytochemicals have potential anti-cancer activities due to their vast structural diversity. Alkaloids have been extensively used in cancer treatment, especially lung cancers, among the plant-based compounds. However, their utilization is limited by their poor solubility, low bioavailability, and inadequacies such as lack of specificity to cancer cells and indiscriminate distribution in the tissues. Incorporating the alkaloids into nanoformulations can overcome the said limitations paving the way for effective delivery of the alkaloids to the site of action in sufficient concentrations, which is crucial in tumor targeting. Our review attempts to assess whether alkaloid nanoformulation can be an effective tool in lung cancer therapy. The mechanism of action of each alkaloid having potential is explored in great detail in the review. In general, Alkaloids suppress oncogenesis by modulating several signaling pathways involved in multiplication, cell cycle, and metastasis, making them significant component of many clinical anti-cancerous agents. The review also explores the future prospects of alkaloid nanoformulation in lung cancer. So, in conclusion, alkaloid based nanoformulation will emerge as a potential gamechanger in treating lung cancer in the near future.

show abstract

“…In recent days, the production of nanopharmaceuticals has revolutionized the pharmaceutical industry by improving the performance of poorly soluble compounds. Nanoapproaches are known to enhance solubility/dissolution rate and to improve bioavailability/oral absorption [16][17][18][19].…”

Section: Introductionmentioning

confidence: 99%

Investigating the Feasibility of Mefenamic Acid Nanosuspension for Pediatric Delivery: Preparation, Characterization, and Role of Excipients

Perween¹,

Alshehri

Easwari³

et al. 2021

Processes

View full text Add to dashboard Cite

Molecules with poor aqueous solubility are difficult to formulate using conventional approaches and are associated with many formulation delivery issues. To overcome these obstacles, nanosuspension technology can be one of the promising approaches. Hence, in this study, the feasibility of mefenamic acid (MA) oral nanosuspension was investigated for pediatric delivery by studying the role of excipients and optimizing the techniques. Nanosuspensions of MA were prepared by adopting an antisolvent precipitation method, followed by ultrasonication with varying concentrations of polymers, surfactants, and microfluidics. The prepared nanosuspensions were evaluated for particle size, morphology, and rheological measures. Hydroxypropyl methylcellulose (HPMC) with varying concentrations and different stabilizers including Tween® 80 and sodium dodecyl sulfate (SLS) were used to restrain the particle size growth of the developed nanosuspension. The optimized nanosuspension formula was stable for more than 3 weeks and showed a reduced particle size of 510 nm with a polydispersity index of 0.329. It was observed that the type and ratio of polymer stabilizers were responsive on the particle contour and dimension and stability. We have developed a biologically compatible oral nanoformulation for a first-in-class drug beautifully designed for pediatric delivery that will be progressed toward further in vivo enabling studies. Finally, the nanosuspension could be considered a promising carrier for pediatric delivery of MA through the oral route with enhanced biological impact.

show abstract

Nanomedicine-based approaches for improved delivery of phyto-therapeutics for cancer therapy

Cited by 24 publications

References 36 publications

Piperine phytosomes for bioavailability enhancement of domperidone

Piperine phytosomes for bioavailability enhancement of domperidone

A spotlight on alkaloid nanoformulations for the treatment of lung cancer

Investigating the Feasibility of Mefenamic Acid Nanosuspension for Pediatric Delivery: Preparation, Characterization, and Role of Excipients

Contact Info

Product

Resources

About