Investigating the Feasibility of Mefenamic Acid Nanosuspension for Pediatric Delivery: Preparation, Characterization, and Role of Excipients

Abstract

Molecules with poor aqueous solubility are difficult to formulate using conventional approaches and are associated with many formulation delivery issues. To overcome these obstacles, nanosuspension technology can be one of the promising approaches. Hence, in this study, the feasibility of mefenamic acid (MA) oral nanosuspension was investigated for pediatric delivery by studying the role of excipients and optimizing the techniques. Nanosuspensions of MA were prepared by adopting an antisolvent precipitation method, followed by ultrasonication with varying concentrations of polymers, surfactants, and microfluidics. The prepared nanosuspensions were evaluated for particle size, morphology, and rheological measures. Hydroxypropyl methylcellulose (HPMC) with varying concentrations and different stabilizers including Tween® 80 and sodium dodecyl sulfate (SLS) were used to restrain the particle size growth of the developed nanosuspension. The optimized nanosuspension formula was stable for more than 3 weeks and showed a reduced particle size of 510 nm with a polydispersity index of 0.329. It was observed that the type and ratio of polymer stabilizers were responsive on the particle contour and dimension and stability. We have developed a biologically compatible oral nanoformulation for a first-in-class drug beautifully designed for pediatric delivery that will be progressed toward further in vivo enabling studies. Finally, the nanosuspension could be considered a promising carrier for pediatric delivery of MA through the oral route with enhanced biological impact.

Investigating Antiarthritic Potential of Nanostructured Clove Oil (Syzygium aromaticum) in FCA-Induced Arthritic Rats: Pharmaceutical Action and Delivery Strategies

“…The developed nanoproduct was evaluated for various pharmaceutical properties as per the standard protocol mentioned below [ 37 , 38 ].…”

“…A high-performance thin layer chromatography (HPTLC) method was employed for all analyses of the marker compound as it is a simple and economical method [ 36 ]. Pharmaceutical evaluation, product stability, and biological studies were performed as per previously published reports [ 2 , 32 , 37 ]. According to the findings, designing appropriate nanolipidic carriers could be a successful method to improve CO benefits in RA.…”

Enhancing Ocular Bioavailability of Ciprofloxacin Using Colloidal Lipid-Based Carrier for the Management of Post-Surgical Infection

“…The minimum and maximum zeta potential values were recorded for formulations A0 (3.6 mV) and A3 (25.7 mV), respectively. The zeta potential value in the range of ±30 mV indicated the maximum stability of formulations [ 15 ]. The zeta potential of liposomal formulation A3 was found to be much closed with ±30 mV, indicating the maximum stability of liposomal formulation A3 compared to the other formulations studied.…”

Developing Nanosuspension Loaded with Azelastine for Potential Nasal Drug Delivery: Determination of Proinflammatory Interleukin IL-4 mRNA Expression and Industrial Scale-Up Strategy

“…By using the nanoprecipitation approach with a little modification to the previously described procedure, the chondroitin-based nanosuspension was prepared . Chondroitin solution was prepared in 0.66% (v/v) ethanol (10 mL), and pH of the chondroitin solution was raised to 5.5 by adding a solution of NaOH (temperature maintained at 50 °C with 1000 stirring speed).…”