Molecules with poor aqueous solubility are difficult to formulate using conventional approaches and are associated with many formulation delivery issues. To overcome these obstacles, nanosuspension technology can be one of the promising approaches. Hence, in this study, the feasibility of mefenamic acid (MA) oral nanosuspension was investigated for pediatric delivery by studying the role of excipients and optimizing the techniques. Nanosuspensions of MA were prepared by adopting an antisolvent precipitation method, followed by ultrasonication with varying concentrations of polymers, surfactants, and microfluidics. The prepared nanosuspensions were evaluated for particle size, morphology, and rheological measures. Hydroxypropyl methylcellulose (HPMC) with varying concentrations and different stabilizers including Tween® 80 and sodium dodecyl sulfate (SLS) were used to restrain the particle size growth of the developed nanosuspension. The optimized nanosuspension formula was stable for more than 3 weeks and showed a reduced particle size of 510 nm with a polydispersity index of 0.329. It was observed that the type and ratio of polymer stabilizers were responsive on the particle contour and dimension and stability. We have developed a biologically compatible oral nanoformulation for a first-in-class drug beautifully designed for pediatric delivery that will be progressed toward further in vivo enabling studies. Finally, the nanosuspension could be considered a promising carrier for pediatric delivery of MA through the oral route with enhanced biological impact.
Background: Psoriasis is a challenging skin disorder due to its chronicity, high rate of prevalence, disability, comorbidity and disfiguration. It is a multi-system disorder that includes joints and metabolic syndromes. Psoriasis is a condition of pathologic interaction among immune cells, biological signaling molecules and skin cells. Several contributing factors are responsible for the exacerbation and onset of psoriasis i.e. genetic factors and environmental factors such as medications, infectious diseases and lifestyle. Objectives: To study about the new insight in the treatment of psoriasis and future prospects. Methods: This review article gives insight of current concepts of psoriasis and deals in discussing the initiation and development of the diseases. We described the pathogenetic pathway for psoriasis. The article focuses of the treatment approaches for psoriasis that have arisen from the dissection of the inflammatory psoriatic pathways. Results: We aimed to highlight the novel therapies, and drugs used in the treatment of psoriasis including food and drug administration (FDA) approved drugs and drugs under clinical trials. The treatment can be initiated from mild to moderate diseased condition including vitamin D3 analogues, corticosteroids and combination of products as first-line therapy. Conclusion: Psoriasis can be managed by proper understanding of immune function. We have also discussed about medicinal herbs used for psoriasis based on their ethnopharmacological knowledge and reported work of researchers.
Purpose: To employ intramolecular cyclization of Schiff bases of pyrazole-4-carboxaldehydes to form thiazolidine-4-ones and determine the antioxidant and antidiabetic rosiglitazone, compounds 7a, 7b, 7c, 7h, 7j showed stronger significant antidiabetic effect in hyperglycemic rats due, probably, to the presence of thiazolidine-4-one nucleus as well as parasubstitution on phenyl ring. Conclusion: The 2-
Objectives: This research's primary goals are Leflunomide (LFD) nanoemulgel formulation and characterization for topical administration. Materials and Methods: A pseudo ternary phase diagram was created utilizing castor oil, Tween 20 as the surfactant, PEG 300 as a co-surfactant, and ethanol as the cosolvent. Spontaneous emulsification was used to create LFD-nanoemulgel, which is now commercially available. Gel matrix Carbopol 934 was employed to generate nanoemulgel in the prepared nanoemulsion. Studies on the LFD-globule nanoemulgel's size, physical appearance, viscosity, spreadability, TEM, FTIR drug content, release kinetics, and stability contributed to its characterization and assessment. Optimum nanoemulgel formulation contained 6% castor oil, 36% Tween 80 and PEG 300 as Smix (surfactant and co-surfactant mixture), 46% water, and 12% w/w carbopol 934. Results: The produced nanoemulgel was translucent and had a zeta potential of 26.12 mV and a particle size of 113.55 ± 1.73 nm. The improved formulation has a drug release rate of 98.13% ± 1.20%. They were determined to be ideal for pH, viscosity, and spreadability. According to the stability analysis, the generated nanoemulgel was shown to be stable at temperatures ranging from 25 ± 45°C, according to the stability analysis results. Conclusion: An effective formulation for topical medication delivery using LFD-loaded nanoemulgel has been developed. It may be an alternative drug therapy to the topical application of drugs to treat arthritis.
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