Nanomaterial based aptasensors for clinical and environmental diagnostic applications

Kaur, Harmanjit; Shorie, Munish

doi:10.1039/c9na00153k

Cited by 78 publications

(34 citation statements)

References 139 publications

(149 reference statements)

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“…Aptasensors are a type of biosensors that use the synthesized nucleic acid sequences named aptamer as a detection element. [ 130 ]. The size of the aptamer is smaller than the antibody; therefore, in the same surface area, the amount of the immobilized detection element in the aptasensor is higher than the immunosensor and, subsequently, the linear response range of aptasensors, in the most of the times are wider than immunosensor [ 131 ].…”

Section: Biosensors (Biorecognizer-based Sensors)mentioning

confidence: 99%

“…Recently, a novel strategy for the quantitive measurement of a target using the IRS technique was reported by Tabrizi et al [ 130 ]. The sensitivity of the aptasensor would be higher if the intensity of the reflected light could be changed during the sensing process instead of the wavelength of the reflected light.…”

Section: Biosensors (Biorecognizer-based Sensors)mentioning

confidence: 99%

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Advances in Optical Biosensors and Sensors Using Nanoporous Anodic Alumina

Tabrizi

Ferré‐Borrull

Marsal

2020

Sensors

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This review paper focuses on recent progress in optical biosensors using self-ordered nanoporous anodic alumina. We present the fabrication of self-ordered nanoporous anodic alumina, surface functionalization, and optical sensor applications. We show that self-ordered nanoporous anodic alumina has good potential for use in the fabrication of antibody-based (immunosensor), aptamer-based (aptasensor), gene-based (genosensor), peptide-based, and enzyme-based optical biosensors. The fabricated optical biosensors presented high sensitivity and selectivity. In addition, we also showed that the performance of the biosensors and the self-ordered nanoporous anodic alumina can be used for assessing biomolecules, heavy ions, and gas molecules.

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Section: Biosensors (Biorecognizer-based Sensors)mentioning

confidence: 99%

Section: Biosensors (Biorecognizer-based Sensors)mentioning

confidence: 99%

Advances in Optical Biosensors and Sensors Using Nanoporous Anodic Alumina

Tabrizi

Ferré‐Borrull

Marsal

2020

Sensors

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“…By definition, nanomaterials have at least one dimension that measures on the nanometer scale (<100 nm), often leading to relatively enhanced physical and chemical properties when compared to traditional materials. Nanomaterials, combined with the use of aptamers as the molecular recognition element, have been widely applied to develop optical, electrochemical, and mechanical sensors for environmental monitoring (Kaur and Shorie, 2019).…”

Section: Introductionmentioning

confidence: 99%

Aptamer-Based Biosensors for Environmental Monitoring

2020

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Due to their relative synthetic and chemical simplicity compared to antibodies, aptamers afford enhanced stability and functionality for the detection of environmental contaminants and for use in environmental monitoring. Furthermore, nucleic acid aptamers can be selected for toxic targets which may prove difficult for antibody development. Of particular relevance, aptamers have been selected and used to develop biosensors for environmental contaminants such as heavy metals, small-molecule agricultural toxins, and water-borne bacterial pathogens. This review will focus on recent aptamer-based developments for the detection of diverse environmental contaminants. Within this domain, aptamers have been combined with other technologies to develop biosensors with various signal outputs. The goal of much of this work is to develop cost-effective, user-friendly detection methods that can complement or replace traditional environmental monitoring strategies. This review will highlight recent examples in this area. Additionally, with innovative developments such as wearable devices, sentinel materials, and lab-on-a-chip designs, there exists significant potential for the development of multifunctional aptamer-based biosensors for environmental monitoring. Examples of these technologies will also be highlighted. Finally, a critical perspective on the field, and thoughts on future research directions will be offered.

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“…A few reviews have already been published to highlight the potential of GNPs in the biomedical eld. 4,[44][45][46][47][48][49] However, no recent review explaining the biomedical advancements of GNPs considering historical views, synthesis and modication strategies, and key biomedical achievement is available to spotlight the current advancements in this area. Herein, we have provided up-to-date information on the progress of GNPs for biomedical applications.…”

Section: Introductionmentioning

confidence: 99%