Role of gold nanoparticles in advanced biomedical applications

Abstract

Gold nanoparticles (GNPs) have gained keen interest among researchers in recent years due to their excellent physiochemical properties. In general, GNPs are biocompatible, amenable to desired functionalization, non-corroding, and exhibit...

Functionalized Silica Star-Shaped Nanoparticles and Human Mesenchymal Stem Cells: An In Vitro Model

“…Furthermore, the presence of metals in nanoparticles can strongly influence intercellular signaling and cell–cell communication by interacting, for instance, with transmembrane proteins [ 23 ]. In particular, gold nanomaterials are appealing due to their high stability, biocompatibility, controlled toxicity, and electronic properties [ 24 , 25 , 26 , 27 ]. The preparation of a hierarchical assembly, composed of a silica core and gold nanoparticles on the outer shell [ 28 , 29 ], leads to the manufacturing of hybrid materials with new enhanced features.…”

Application of Nanotechnology in the COVID-19 Pandemic

“…216 It also has the advantage of activating the immune response associated with CD8+ (cytotoxic) T cells by spreading to the lymph nodes. 217 The advantages 218 and disadvantages [219][220][221][222] of applying GNs to nanomedicine have been separately summarized (Table 2).…”

“…Nanoparticle aggregation 211 Impossible biodegradation 220,221 High cost of large-scale production 222 Virus Like Particles (VLPs) Stabilization by disulfide bonds 227,228 Produced by cell-free protein synthesis 227,229 Small molecule, nucleic acid and protein loading capacity 230,231 Functionalization of antibody fragment display for specific cell targeting 232,233 Low stability 227 Phagocytic avoidance 234 Extravasate from blood vessel 235 Cell-Derived Vesicles Low inherent toxicity 246…”

A red light‐activable MnI(CO)3‐functionalized gold nanocomposite as the anticancer prodrug with theranostic potential

“…[9][10][11][12][13][14] Several photoactivable transition metal-based compounds and nanohybrids that generate reactive oxygen species under visible-light activation have emerged as viable alternatives to porphyrin-based photochemotherapeutic agents. [15][16][17][18][19][20][21][22][23][24][25][26][27][28][29][30] The salutary effect of a low dose of CO has prompted research on the photoactivated release of exogenous CO from CO-releasing molecules (CORMs) with spatial and temporal resolution for clinical applications, including cancer therapy. [31][32][33][34][35][36][37][38][39][40][41][42][43][44][45][46][47][48] However, the delivery, tumor specificity, and retention of CORMs in malignant tumors are formidable challenges in utilizing photoCORMs for cancer therapy.…”