Nanoencapsulation of Phytochemicals and in-vitro Applications

Ling, Jordy Kim Ung; Hii, Yiik Siang; Jeevanandam, Jaison; Chan, Yen San; Danquah, Michael K.

doi:10.1007/978-981-13-6920-9_17

Cited by 4 publications

(2 citation statements)

References 53 publications

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“…Moreover, a potential health risk is undertaken due to chemical instability and high degradability when supplied orally and during its path through the stomach due to its low pH [15]. An alternative to the harmful effects is the nanoencapsulation of extracts using matrices that help protect these compounds [16,17]. The importance of applying nanotechnology in nutraceutical and bioactive compounds is its protection against changes in pH during its incorporation into a food, improving its bioavailability when passing through the gastrointestinal tract and not losing its biological activity.…”

Section: Introductionmentioning

confidence: 99%

Nanoencapsulation of Eggplant (Solanum melongena L.) Peel Extract in Electrospun Gelatin Nanofiber: Preparation, Characterization, and In Vitro Release

et al. 2022

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This study describes the preparation and characterization of eggplant peel extract-loaded electrospun gelatin nanofiber and study of its in vitro release. Results obtained by scanning electron microscopy (SEM) and transmission electronic microscopy (TEM) micrograph revealed that eggplant peel extract-loaded electrospun gelatin nanofiber is in nanometric range with an average diameter 606.7 ± 184.5 and 643.6 ± 186.7 nm for 20 and 33.3 mg mL−1 of extract addition, respectively. Moreover, the incorporation of extract improved morphology by being smooth, homogeneous, and without account formation compared to nanofibers without extract (control). Fourier transform-infrared (FT-IR) spectra indicated that interaction exists between electrospun gelatin nanofiber and eggplant peel extract by hydrogen bond interactions, mainly. Electrospun gelatin nanofibers showed encapsulation efficiency greater than 90% of extract and a maximum release of 95 and 80% for the medium at pH 1.5 and 7.5, respectively. Therefore, the electrospinning technique is a good alternative for the conservation of bioactive compounds present in the eggplant peel through electrospun gelatin nanofiber.

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Section: Introductionmentioning

confidence: 99%

Nanoencapsulation of Eggplant (Solanum melongena L.) Peel Extract in Electrospun Gelatin Nanofiber: Preparation, Characterization, and In Vitro Release

et al. 2022

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“…Even though nanoparticles can be fabricated from all the parts of plants, leaves are the most significant part. They can grow faster, do not affect plant development, and contain several secondary metabolites, which is essential as a natural reducing and stabilizing agent for the formation of nanoparticles [ 88 ]. Although this approach can yield less-toxic nanoparticles with the ability to manipulate their size and shape, agglomeration and less stability of the nanoparticles are the major limitations of this method [ 89 ].…”

Section: Synthesis Approaches Of Agnpsmentioning

confidence: 99%

Synthesis approach-dependent antiviral properties of silver nanoparticles and nanocomposites

Jeevanandam

Krishnan²,

Hii

et al. 2022

J Nanostruct Chem

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Graphical abstract Numerous viral infections are common among humans, and some can lead to death. Even though conventional antiviral agents are beneficial in eliminating viral infections, they may lead to side effects or physiological toxicity. Silver nanoparticles and nanocomposites have been demonstrated to possess inhibitory properties against several pathogenic microbes, including archaea, bacteria, fungi, algae, and viruses. Its pronounced antimicrobial activity against various microbe-mediated diseases potentiates its use in combating viral infections. Notably, the appropriated selection of the synthesis method to fabricate silver nanoparticles is a major factor for consideration as it directly impacts antiviral efficacy, level of toxicity, scalability, and environmental sustainability. Thus, this article presents and discusses various synthesis approaches to produce silver nanoparticles and nanocomposites, providing technological insights into selecting approaches to generate antiviral silver-based nanoparticles. The antiviral mechanism of various formulations of silver nanoparticles and the evaluation of its propensity to combat specific viral infections as a potential antiviral agent are also discussed.

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