Phytosynthesized nanoparticles as a potential cancer therapeutic agent

Jeevanandam, Jaison; Kulabhusan, Prabir Kumar; Sabbih, Godfred; Akram, Muhammad; Danquah, Michael K.

doi:10.1007/s13205-020-02516-7

Cited by 20 publications

(5 citation statements)

References 238 publications

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“…The most common precursors include polysaccharides, biodegradable gums, and phytoconstituents of some plants (biodegradable gum). Moreover, phyto-synthesized AgNPs (Ps-AgNPs) have shown essential effects on cancer cell inhibition without affecting healthy cells [67].…”

Section: Phytogenic Agnpsmentioning

confidence: 99%

Lung Models to Evaluate Silver Nanoparticles’ Toxicity and Their Impact on Human Health

et al. 2022

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Nanomaterials (NMs) solve specific problems with remarkable results in several industrial and scientific areas. Among NMs, silver nanoparticles (AgNPs) have been extensively employed as drug carriers, medical diagnostics, energy harvesting devices, sensors, lubricants, and bioremediation. Notably, they have shown excellent antimicrobial, anticancer, and antiviral properties in the biomedical field. The literature analysis shows a selective cytotoxic effect on cancer cells compared to healthy cells, making its potential application in cancer treatment evident, increasing the need to study the potential risk of their use to environmental and human health. A large battery of toxicity models, both in vitro and in vivo, have been established to predict the harmful effects of incorporating AgNPs in these numerous areas or those produced due to involuntary exposure. However, these models often report contradictory results due to their lack of standardization, generating controversy and slowing the advances in nanotoxicology research, fundamentally by generalizing the biological response produced by the AgNP formulations. This review summarizes the last ten years’ reports concerning AgNPs’ toxicity in cellular respiratory system models (e.g., mono-culture models, co-cultures, 3D cultures, ex vivo and in vivo). In turn, more complex cellular models represent in a better way the physical and chemical barriers of the body; however, results should be used carefully so as not to be misleading. The main objective of this work is to highlight current models with the highest physiological relevance, identifying the opportunity areas of lung nanotoxicology and contributing to the establishment and strengthening of specific regulations regarding health and the environment.

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Section: Phytogenic Agnpsmentioning

confidence: 99%

Lung Models to Evaluate Silver Nanoparticles’ Toxicity and Their Impact on Human Health

et al. 2022

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“…This will pose a myriad of challenges for the isolation and purification of nanoparticles from the plant extract. 303 Furthermore, biomass required for the formation of nanoparticles (conversion factor) and the cost factor cannot be standardized in the biosynthesis approach, as it depends on the biomolecules in each organism, which eventually depends on the nutrient level, soil/culture medium quality, seasons, geography, and various other factors. 304 Thus, the conversion and cost factor can be calculated for specific cases, considering these parameters and the type of nanoparticle to be synthesized.…”

Section: Challenges In Green Synthesis and Future Perspectivesmentioning

confidence: 99%

Green approaches for the synthesis of metal and metal oxide nanoparticles using microbial and plant extracts

et al. 2022

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“…Interestingly, ultrasmall-sized gold NPs (<10 nm) can cross the nuclear membrane of breast cancer cells ( Huo et al., 2014 ). Previous studies have suggested that plant extract-assisted synthesis of NPs can be successfully applied to generate NPs in a controlled small and ultrasmall size range 2nm-10nm ( Yang et al., 2019 ; Jeevanandam et al., 2020 ). Moreover, several studies have shown that plant-based generated NPs possess excellent optical, magnetic or mechanical properties ( Dinkar et al., 2021 ).…”

Section: Latex-bearing Plants and Nanotechnologymentioning

confidence: 99%

Tap the sap – investigation of latex-bearing plants in the search of potential anticancer biopharmaceuticals

Mazur

Bałdysz²,

Warowicka³

et al. 2022

Front. Plant Sci.

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Latex-bearing plants have been in the research spotlight for the past couple of decades. Since ancient times their extracts have been used in folk medicine to treat various illnesses. Currently they serve as promising candidates for cancer treatment. Up to date there have been several in vitro and in vivo studies related to the topic of cytotoxicity and anticancer activity of extracts from latex-bearing plants towards various cell types. The number of clinical studies still remains scarce, however, over the years the number is systematically increasing. To the best of our knowledge, the scientific community is still lacking in a recent review summarizing the research on the topic of cytotoxicity and anticancer activity of latex-bearing plant extracts. Therefore, the aim of this paper is to review the current knowledge on in vitro and in vivo studies, which focus on the cytotoxicity and anticancer activities of latex-bearing plants. The vast majority of the studies are in vitro, however, the interest in this topic has resulted in the substantial growth of the number of in vivo studies, leading to a promising number of plant species whose latex can potentially be tested in clinical trials. The paper is divided into sections, each of them focuses on specific latex-bearing plant family representatives and their potential anticancer activity, which in some instances is comparable to that induced by commonly used therapeutics currently available on the market. The cytotoxic effect of the plant’s crude latex, its fractions or isolated compounds, is analyzed, along with a study of cell apoptosis, chromatin condensation, DNA damage, changes in gene regulation and morphology changes, which can be observed in cell post plant extract addition. The in vivo studies go beyond the molecular level by showing significant reduction of the tumor growth and volume in animal models. Additionally, we present data regarding plant-mediated biosynthesis of nanoparticles, which is regarded as a new branch in plant latex research. It is solely based on the green-synthesis approach, which presents an interesting alternative to chemical-based nanoparticle synthesis. We have analyzed the cytotoxic effect of these particles on cells. Data regarding the cytotoxicity of such particles raises their potential to be involved in the design of novel cancer therapies, which further underlines the significance of latex-bearing plants in biotechnology. Throughout the course of this review, we concluded that plant latex is a rich source of many compounds, which can be further investigated and applied in the design of anticancer pharmaceuticals. The molecules, to which this cytotoxic effect can be attributed, include alkaloids, flavonoids, tannins, terpenoids, proteases, nucleases and many novel compounds, which still remain to be characterized. They have been studied extensively in both in vitro and in vivo studies, which provide an excellent starting point for their rapid transfer to clinical studies in the near future. The comprehensive study of molecules from latex-bearing plants can result in finding a promising alternative to several pharmaceuticals on the market and help unravel the molecular mode of action of latex-based preparations.

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Phytosynthesized nanoparticles as a potential cancer therapeutic agent

Cited by 20 publications

References 238 publications

Lung Models to Evaluate Silver Nanoparticles’ Toxicity and Their Impact on Human Health

Lung Models to Evaluate Silver Nanoparticles’ Toxicity and Their Impact on Human Health

Green approaches for the synthesis of metal and metal oxide nanoparticles using microbial and plant extracts

Tap the sap – investigation of latex-bearing plants in the search of potential anticancer biopharmaceuticals

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