Synthesis approach-dependent antiviral properties of silver nanoparticles and nanocomposites

Jeevanandam, Jaison; Krishnan, Saravanan; Hii, Yiik Siang; Pan, Sharadwata; Chan, Yen San; Acquah, Caleb; Danquah, Michael K.; Rodrigues, João

doi:10.1007/s40097-021-00465-y

Cited by 51 publications

(33 citation statements)

References 225 publications

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“…The silver nanoparticles’ antibacterial mechanism is illustrated in Figure 1 . Silver nanoparticles are used in biomedical and therapeutical applications such as molecular diagnostics, medical imaging, drug delivery, surgical mesh, wound dressings, artificial joint replacements, and medicaments for wound healing promotion [ 8 , 9 ] Silver nanoparticles can be manufactured in various routes [ 10 , 11 , 12 ]. Helmlinger et al investigated the influence of silver nanoparticle morphology on dissolution kinetics and its effect on cells and bacteria.…”

Section: Introductionmentioning

confidence: 99%

The Antibacterial and Cytotoxic Effects of Silver Nanoparticles Coated Titanium Implants: A Narrative Review

et al. 2022

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Nanotechnology has become an emerging research field with numerous biomedical scientific applications. Silver possesses bactericidal activities that have been harnessed for centuries; however, there is a concern about the toxic effects of silver nanoparticles. This paper aims to provide an overview of silver-treated dental implants and discuss their potential to reduce the prevalence of peri-implant diseases. An electronic search was performed using PubMed. After screening, data extraction was performed on the 45 remaining articles using inclusion and exclusion criteria. Most of the articles demonstrated that silver nanoparticles embedded in a coating layer and/or on surface-treated titanium exhibit sound antibacterial effects and biocompatibility. Most of the reviewed studies revealed that silver nanoparticles on dental implant surfaces reduced cytotoxicity but provided a prolonged antibacterial effect. The cytotoxicity and antibacterial effect are closely linked to how the silver nanoparticles are released from the titanium surfaces, where a slower release increases cell viability and proliferation. However, to improve the clinical translation, there is still a need for more studies, especially evaluating the long-term systemic effects and studies recreating the conditions in the oral cavity.

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Section: Introductionmentioning

confidence: 99%

The Antibacterial and Cytotoxic Effects of Silver Nanoparticles Coated Titanium Implants: A Narrative Review

et al. 2022

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“…Despite extensive research and proven antiviral properties, the implementation of nanosilver in commercial antiviral drugs is limited [ 2 , 20 , 21 , 22 ]. Cytotoxicity is a major limitation for their use as antiviral agents in biomedical applications [ 23 ]. Commercially available Sovereign Silver and Argentyn 23 manufactured by Natural Immunogenics Corp (NIC) contain a mixture of silver cations and NPs [ 24 ].…”

Section: Introductionmentioning

confidence: 99%

Targeting of Silver Cations, Silver-Cystine Complexes, Ag Nanoclusters, and Nanoparticles towards SARS-CoV-2 RNA and Recombinant Virion Proteins

Морозова

Manuvera

Grishchechkin

et al. 2022

Viruses

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Nanosilver possesses antiviral, antibacterial, anti-inflammatory, anti-angiogenesis, antiplatelet, and anticancer properties. The development of disinfectants, inactivated vaccines, and combined etiotropic and immunomodulation therapy against respiratory viral infections, including COVID-19, remains urgent. Aim: Our goal was to determine the SARS-CoV-2 molecular targets (genomic RNA and the structural virion proteins S and N) for silver-containing nanomaterials. Methods: SARS-CoV-2 gene cloning, purification of S2 and N recombinant proteins, viral RNA isolation from patients’ blood samples, reverse transcription with quantitative real-time PCR ((RT)2-PCR), ELISA, and multiplex immunofluorescent analysis with magnetic beads (xMAP) for detection of 17 inflammation markers. Results: Fluorescent Ag nanoclusters (NCs) less than 2 nm with a few recovered silver atoms, citrate coated Ag nanoparticles (NPs) with diameters of 20–120 nm, and nanoconjugates of 50–150 nm consisting of Ag NPs with different protein envelopes were constructed from AgNO3 and analyzed by means of transmission electron microscopy (TEM), atomic force microscopy (AFM), ultraviolet-visible light absorption, and fluorescent spectroscopy. SARS-CoV-2 RNA isolated from COVID-19 patients’ blood samples was completely cleaved with the artificial RNase complex compound Li+[Ag+2Cys2−(OH−)2(NH3)2] (Ag-2S), whereas other Ag-containing materials provided partial RNA degradation only. Treatment of the SARS-CoV-2 S2 and N recombinant antigens with AgNO3 and Ag NPs inhibited their binding with specific polyclonal antibodies, as shown by ELISA. Fluorescent Ag NCs with albumin or immunoglobulins, Ag-2S complex, and nanoconjugates of Ag NPs with protein shells had no effect on the interaction between coronavirus recombinant antigens and antibodies. Reduced production of a majority of the 17 inflammation biomarkers after treatment of three human cell lines with nanosilver was demonstrated by xMAP. Conclusion: The antiviral properties of the silver nanomaterials against SARS-CoV-2 coronavirus differed. The small-molecular-weight artificial RNase Ag-2Sprovided exhaustive RNA destruction but could not bind with the SARS-CoV-2 recombinant antigens. On the contrary, Ag+ ions and Ag NPs interacted with the SARS-CoV-2 recombinant antigens N and S but were less efficient at performing viral RNA cleavage. One should note that SARS-CoV-2 RNA was more stable than MS2 phage RNA. The isolated RNA of both the MS2 phage and SARS-CoV-2 were more degradable than the MS2 phage and coronavirus particles in patients’ blood, due to the protection with structural proteins. To reduce the risk of the virus resistance, a combined treatment of Ag-2S with Ag NPs could be used. To prevent cytokine storm during the early stages of respiratory infections with RNA-containing viruses, nanoconjugates of Ag NPs with surface proteins could be used.

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“…NPs are between 1–100 nm and the increase in the use of AgNPs compared with other metal NPs is due to their physical-chemical characteristics and the well-known toxic effect of silver, which gives them good antimicrobial capabilities [ 1 , 2 , 3 ]. Depending on how they are synthesized, their size, and their morphology, AgNPs have unique and different characteristics, which allows them to be applied in a wide range of functions such as biosensors and anticancer therapy, in bioimaging, wound healing, disease treatment and drug delivery, or as nutraceuticals [ 4 , 5 ]. To date, several studies described the potent antimicrobial activity of AgNPs against bacteria, considering them an effective alternative to dealing with the problem of bacterial multidrug resistance such as ampicillin-resistant Escherichia coli , erythromycin-resistant Streptococcus pyogenes and methicillin-resistant or vancomycin-resistant Staphylococcus aureus and the concomitant increase in the number of infections [ 3 , 6 , 7 , 8 ].…”

Section: Introductionmentioning

confidence: 99%

A Promising Antifungal and Antiamoebic Effect of Silver Nanorings, a Novel Type of AgNP

González-Fernández

Lozano-Iturbe

Menéndez³

et al. 2022

Antibiotics

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Silver nanoparticles (AgNPs) play an important role in the medical field due to their potent antimicrobial activity. This, together with the constant emergence of resistance to antimicrobial drugs, means AgNPs are often investigated as an alternative to solve this problem. In this article, we analyzed the antifungal and antiamoebic effects of a recently described type of AgNP, silver nanorings (AgNRs), and compared them with other types of AgNPs. Tests of the activity of AgNPs against various fungal and amoebic species were carried out. In all cases, AgNPs showed a high biocidal effect, although with fungi this depended on the species involved. Antifungal activity was detected by the conditioning of culture media or water but this effect was not dependent on the release of Ag ions. On the other hand, the proliferation of Acanthamoeba castellanii trophozoites was reduced by silver nanorings (AgNRs) and silver nanowires (AgNWs), with AgNWs being capable of totally inhibiting the germination of A. castellanii cysts. AgNRs constitute a new type of AgNP with an antifungal and antiacanthamoebic activity. These results open the door to new and effective antimicrobial therapies as an alternative to the use of antifungals or antiamoebic drugs, thus avoiding the constant appearance of resistance and the difficulty of eradicating infections.

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Synthesis approach-dependent antiviral properties of silver nanoparticles and nanocomposites

Cited by 51 publications

References 225 publications

The Antibacterial and Cytotoxic Effects of Silver Nanoparticles Coated Titanium Implants: A Narrative Review

The Antibacterial and Cytotoxic Effects of Silver Nanoparticles Coated Titanium Implants: A Narrative Review

Targeting of Silver Cations, Silver-Cystine Complexes, Ag Nanoclusters, and Nanoparticles towards SARS-CoV-2 RNA and Recombinant Virion Proteins

A Promising Antifungal and Antiamoebic Effect of Silver Nanorings, a Novel Type of AgNP

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