Nanoemulsions loaded Carbopol® 934 based gel for intranasal delivery of neuroprotective Centella asiatica extract: in–vitro and ex–vivo permeation study

Jaiswal, Maneesh; Kumar, Arun; Sharma, Shivani

doi:10.1007/s40005-016-0228-1

Cited by 47 publications

(17 citation statements)

References 28 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The flow curves shown in Figure 1F indicated that the gels revealed a nonnewtonian, pseudo plastic flow pattern (increasing shear speed with a decrease in viscosity), maximizing the area coverage on application. Thus, it is an important characteristic for topical formulations 40,41…”

Section: Resultsmentioning

confidence: 99%

<p>Enhanced transdermal delivery of lornoxicam by nanostructured lipid carrier gels modified with polyarginine peptide for treatment of carrageenan-induced rat paw edema</p>

Gao¹,

Tian²,

Han³

et al. 2019

IJN

View full text Add to dashboard Cite

Background: Nanostructured lipid carriers (NLCs) are emerging as attractive drug carriers in transdermal drug delivery. The surface modification of NLCs with cell-penetrating peptides (CPPs) can enhance the skin permeation of drugs. Purpose: The objective of the current study was to evaluate the ability of the cell-penetrating peptide (CPP) polyarginine to translocate NLCs loaded with lornoxicam (LN) into the skin layers and to evaluate its anti-inflammatory effect. Methods: The NLCs were prepared using an emulsion evaporation and low temperature solidification technique using glyceryl monostearates, triglycerides, DOGS-NTA-Ni lipids and surfactants, and then six histidine-tagged polyarginine containing 11 arginine (R11) peptides was modified on the surface of NLCs. Results: The developed NLCs formulated with LN and R11 (LN-NLC-R11) were incorporated into 2% HPMC gels. NLCs were prepared with a particle size of (121.81±3.61)–(145.72±4.78) nm, and the zeta potential decreased from (−30.30±2.07) to (−14.66±0.74) mV after the modification of R11 peptides. The encapsulation efficiency and drug loading were (74.61±1.13) % and (7.92±0.33) %, respectively, regardless of the surface modification. Cellular uptake assays using HaCaT cells suggested that the NLC modified with R11 (0.02%, w/w) significantly enhanced the cell internalization of nanoparticles relative to unmodified NLCs ( P <0.05 or P <0.01). An in vitro skin permeation study showed better permeation-enhancing ability of R11 (0.02%, w/w) than that of other content (0.01% or 0.04%). In carrageenan-induced rat paw edema models, LN-NLC-R11 gels inhibited rat paw edema and the production of inflammatory cytokines compared with LN-NLC gels and LN gels ( P <0.01). Conclusion: In our investigation, it was strongly demonstrated that the surface modification of NLC with R11 enhanced the translocation of LN across the skin, thereby alleviating inflammation.

show abstract

Section: Resultsmentioning

confidence: 99%

<p>Enhanced transdermal delivery of lornoxicam by nanostructured lipid carrier gels modified with polyarginine peptide for treatment of carrageenan-induced rat paw edema</p>

Gao¹,

Tian²,

Han³

et al. 2019

IJN

View full text Add to dashboard Cite

show abstract

“…NEs could enhance drug solubility and mucosal permeation [150]. Regarding their nature and the possibility for the addition of excipients, such as mucoadhesive and gel-forming polymers, NEs can provide a novel intranasal delivery system that meets the criteria of drug protection, mucosal adhesion, and permeation enhancement [151]. Intranasal NEs have been studied for their activity on systemic, brain targeting, and vaccine delivery, but not for local delivery due to the effect of absorption that would transfer the drug from the local site to the systemic circulation or even the brain.…”

Section: Nanoemulsions (Nes)mentioning

confidence: 99%

Intranasal Nanoparticulate Systems as Alternative Route of Drug Delivery

Alshweiat

Ambrus

Csóka

2019

CMC

View full text Add to dashboard Cite

There is always a need for alternative and efficient methods of drug delivery. The nasal cavity can be considered as a non-invasive and efficient route of administration. It has been used for local, systemic, brain targeting, and vaccination delivery. Although many intranasal products are currently available on the market, the majority is used for local delivery with fewer products available for the other targets. As nanotechnology utilization in drug delivery has rapidly spread out, the nasal delivery has become attractive as a promising approach. Nanoparticulate systems facilitate drug transportation across the mucosal barrier, protect the drug from nasal enzyme degradation, enhance the delivery of vaccines to the lymphoid tissue of the nasal cavity with an adjuvant activity, and offer a way for peptide delivery into the brain and the systemic circulation, in addition to their potential for brain tumor treatment. This review article aims at discussing the potential benefit of the intranasal nanoparticulate systems, including nanosuspensions, lipid and surfactant, and polymer-based nanoparticles as regards productive intranasal delivery. The aim of this review is to focus on the topicalities of nanotechnology applications for intranasal delivery of local, systemic, brain, and vaccination purposes during the last decade, referring to the factors affecting delivery, regulatory aspects, and patient expectations. This review further identifies the benefits of applying the Quality by Design approaches (QbD) in product development. According to the reported studies on nanotechnology-based intranasal delivery, potential attention has been focused on brain targeting and vaccine delivery with promising outcomes. Despite the significant research effort in this field, nanoparticle-based products for intranasal delivery are not available. Thus, further efforts are required to promote the introduction of intranasal nanoparticulate products that can meet the requirements of regulatory affairs with high patient acceptance.

show abstract

“…[9,15] On the other hand, carbopol is a hydrophilic, non-toxic, biocompatible, bioadhesive and non-irritant polymer. [16,17] It has been used in drug delivery systems for buccal, transdermal, [18] ocular, rectal, vaginal, [19] nasal [20] and wound dressing applications. [21] 2 Experimental…”

Section: Introductionmentioning

confidence: 99%

Functionalization of carbopol with NVP for designing antibiotic drug loaded hydrogel dressings for better wound management

Singh

Dhiman

2019

J Pharm Biopharm Res

View full text Add to dashboard Cite

In the present work an attempt has been made to design the antibiotic drug loaded carbopolpoly(NVP) based hydrogel wound dressings for better wound care. The polymer films were characterized by SEM-EDX, AFM, FTIR, 13 CNMR, TGA/DTA/DTG, DSC, and swelling studies. Besides drug release, various biomedical properties (viz. blood compatibility, mucoadhesion, oxygen permeability, water vapour transmission rate, microbial penetration, tensile strength, bursting strength, resilience, stress relaxation, and folding endurance) have also been studied. The polymer films have been observed to be biocompatible, permeable to oxygen and water vapour and have absorbed simulated wound fluid 11.37±0.31g/g of polymer film. The drug release profile followed the Case-II diffusion mechanism and release profile best fitted in Hixson-Crowell's kinetic models. Mechanical properties results showed that the polymer film had 0.65±0.12 Nmm −2 tensile strength, 119.38±14.26% elongationand 25.49±0.72% resilience.

show abstract

Nanoemulsions loaded Carbopol® 934 based gel for intranasal delivery of neuroprotective Centella asiatica extract: in–vitro and ex–vivo permeation study

Cited by 47 publications

References 28 publications

<p>Enhanced transdermal delivery of lornoxicam by nanostructured lipid carrier gels modified with polyarginine peptide for treatment of carrageenan-induced rat paw edema</p>

<p>Enhanced transdermal delivery of lornoxicam by nanostructured lipid carrier gels modified with polyarginine peptide for treatment of carrageenan-induced rat paw edema</p>

Intranasal Nanoparticulate Systems as Alternative Route of Drug Delivery

Functionalization of carbopol with NVP for designing antibiotic drug loaded hydrogel dressings for better wound management

Contact Info

Product

Resources

About