Nanoconjugates of ferrocene and carbon-encapsulated iron nanoparticles as sensing platforms for voltammetric determination of ceruloplasmin in blood

Sęk, Jakub P.; Kasprzak, Artur; Bystrzejewski, M.; Popławska, Magdalena; Kaszuwara, W.; Stojek, Zbigniew; Nowicka, Anna M.

doi:10.1016/j.bios.2017.11.060

Cited by 19 publications

(7 citation statements)

References 48 publications

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“…The materials were obtained via the one-step cycloaddition reaction (CEINs-Fc-1 47 and CEINs-Fc-2 48 ) or the three-step protocol (CEINs-Fc-3). 49 It should be noted that the materials differ in the type of linker between the CEINs and Fc as well as in content of the Fc moiety (21.2, 16.3, and 6.3 wt % for CEINs-Fc-1, CEINs-Fc-2, and CEINs-Fc-3, respectively). Importantly, cyclic voltammetry studies revealed the electrochemical activity of the nanoconjugates, as the fully reversible redox processes of the Fc ligand attached to CEINs were observed.…”

Section: ■ Results and Discussionmentioning

confidence: 99%

Ferrocene-Labeled Carbon-Encapsulated Iron Nanoparticles: The First Magnetic Nanocatalysts for C–H Arylation toward 1,1′-Biphenyl Formation

Kasprzak

Bystrzejewski

Popławska

2019

Org. Process Res. Dev.

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The first magnetic nanocatalysts for C–H arylation toward 1,1′-biphenyl formation are described. The nanocatalysts are based on conjugates of ferrocene and carbon-encapsulated iron nanoparticles. The highest catalytic activity was found for ferrocene conjugated to carbon-encapsulated iron nanoparticles via the N-methylpyrrolidine moiety. In the presence of the nanocatalyst, various 1,1′-biphenyls can be obtained in high yields (84–90%). The effect of substitution of the aniline’s phenyl ring on the reaction yield is also included in this work. The nanocatalyst can be easily separated from the reaction mixture and can be reused in up to four reaction cycles without any loss of its high catalytic activity. Our work sheds light on a potential application of functionalized carbon-encapsulated iron nanoparticles in modern industrial organic processes toward more economical manufacturing of organic compounds.

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Section: ■ Results and Discussionmentioning

confidence: 99%

Ferrocene-Labeled Carbon-Encapsulated Iron Nanoparticles: The First Magnetic Nanocatalysts for C–H Arylation toward 1,1′-Biphenyl Formation

Kasprzak

Bystrzejewski

Popławska

2019

Org. Process Res. Dev.

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“…Other metal-based nanoparticles like copper nanoparticles (CuNPs), iron nanoparticles (FeNPs), and platinum nanoparticles (PtNPs) are less exploited in colorimetric assays as transducers but rather explored for other properties like catalysis or magnetism. [65][66][67][68][69][70][71][72] Fluorescence based aptasensors Akin to colorimetric sensors, uorescent platforms rely on the changes in the uorescence signal between on and off states and in shi in wavelengths with spectrally overlapping uorescent pairs. This adds stringency to the assay by reducing the background signal and increasing sensitivity by applying a narrow excitation source.…”

Section: Colorimetric Aptasensorsmentioning

confidence: 99%

Nanomaterial based aptasensors for clinical and environmental diagnostic applications

Kaur

Shorie

2019

Nanoscale Adv.

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“…Among potential applications of these conjugates are those including but not limited to development of homogeneous assays, for example, FRET-or particle aggregation-based assays, demanding high nanoparticle stability. Another promising direction of future research is the functionalization of carbon-coated nanoparticles widely used in biosensing, 62 theranostics, 63 and biotechnology, 64 taking into account possible differences in surface chemistry. Talking about future research, we believe that excellent aggregation stability and presence of inert protein coating layer of conjugates may be beneficial for the development of in vivo diagnostics and drug delivery agents.…”

Section: ■ Conclusionmentioning

confidence: 99%

Highly Stable Conjugates of Carbon Nanoparticles with DNA Aptamers

et al. 2018

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Conjugates of carbon nanoparticles and aptamers have great potential in many areas of biomedicine. In order to be implemented in practice, such conjugates should keep their properties throughout long storage period in commonly available conditions. In this work, we prepared conjugates of carbon nanoparticles (CNP) with DNA aptamers using streptavidin-biotin reaction. Obtained conjugates possess superior stability and kept their physical-chemical and functional properties during 30 days at +4 °C and -20 °C. Proposed approach to conjugation allows loading of about 100-120 pM of biotinylated aptamer per 1 mg of streptavidin-coated CNP (CNP-Str). Aptamer-functionalized CNP-Str have zeta potential of -34 mV at pH 7, mean diameter of 168-177 nm, and polydispersity index of 0.080-0.140. High reproducibility of functionalization was confirmed by preparation of several batches of CNP-aptamer with the same size distribution and aptamer loading using independently synthesized parent CNP-Str nanoparticles. Stability of CNP-aptamer conjugates was significantly enhanced by postsynthesis addition of EDTA that prevents nuclease degradation of immobilized aptamers. Obtained nanoparticles were stable at pH ranging from 6 to 10. Optical properties of CNP-aptamer nanoparticles were also studied and their ability to quench fluorescence via Förster resonance energy transfer was shown. Taking into account properties of CNP-aptamer conjugates, we suppose they may be used in both homo- and heterogeneous colorimetric, fluorescent, and aggregation-based assays.

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Nanoconjugates of ferrocene and carbon-encapsulated iron nanoparticles as sensing platforms for voltammetric determination of ceruloplasmin in blood

Cited by 19 publications

References 48 publications

Ferrocene-Labeled Carbon-Encapsulated Iron Nanoparticles: The First Magnetic Nanocatalysts for C–H Arylation toward 1,1′-Biphenyl Formation

Ferrocene-Labeled Carbon-Encapsulated Iron Nanoparticles: The First Magnetic Nanocatalysts for C–H Arylation toward 1,1′-Biphenyl Formation

Nanomaterial based aptasensors for clinical and environmental diagnostic applications

Highly Stable Conjugates of Carbon Nanoparticles with DNA Aptamers

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