Nano‑calcium phosphate bone cement based on Si-stabilized α-tricalcium phosphate with improved mechanical properties

Roozbahani, M.; Alehosseini, Morteza; Kharaziha, Mahshid; Emadi, Rahmatollah

doi:10.1016/j.msec.2017.08.016

Cited by 24 publications

(17 citation statements)

References 48 publications

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“…Si‐stabilized α‐TCP powder was synthesized in a two‐step process of sol–gel and mechanical alloying, according to the recent research . Figure 1 schematically presents Si‐stabilized α‐TCP synthesize process.…”

Section: Methodsmentioning

confidence: 99%

“…Nonetheless, the inadequate accessibility and donor site injury associated with autografts confine their widely application in the clinic approaches . Therefore, there is significant interest in developing of alternatives consisting of allografts, xenografts and tissue engineering approaches . Bone tissue engineering aims at refining the strength of musculoskeletal tissue via incorporation of a bone graft substitute to encourage formation of bone from the surrounding tissue or to act as a template for inserted bone cells .…”

Section: Introductionmentioning

confidence: 99%

“…Therefore, there is significant interest in developing of alternatives consisting of allografts, xenografts and tissue engineering approaches . Bone tissue engineering aims at refining the strength of musculoskeletal tissue via incorporation of a bone graft substitute to encourage formation of bone from the surrounding tissue or to act as a template for inserted bone cells . There are several strategies suggested by tissue engineering to regenerate bone tissue which do not need secondary surgery such as bone cement to fill cavity, and bone scaffolds and membranes .…”

Section: Introductionmentioning

confidence: 99%

“…Bone tissue engineering aims at refining the strength of musculoskeletal tissue via incorporation of a bone graft substitute to encourage formation of bone from the surrounding tissue or to act as a template for inserted bone cells . There are several strategies suggested by tissue engineering to regenerate bone tissue which do not need secondary surgery such as bone cement to fill cavity, and bone scaffolds and membranes . Between them, the membranes could provide the appropriate environment for new tissue growth without stimulation immune system responses .…”

Section: Introductionmentioning

confidence: 99%

“…Therefore, nanocomposite membranes based on PCL combined with bioactive components were developed to reproduce the osteogenic niches offered by autografts. Recently, bioactive components consisting of hydroxyapatite (HA), tricalcium phosphate (TCP), forsterite, diopside, and biphasic calcium phosphate (BCP) have been applied to reproduce the osteogenic niche offered by autografts. Among these ceramics, Ca–P based ceramics such as TCP (Ca 3 (PO 4 ) 2 ) has drawn an excessive deal of attention for bone tissue engineering applications owing to its biocompatibility, osteoconductivity, and resobability .…”

Section: Introductionmentioning

confidence: 99%

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Hemocompatible and Bioactive Heparin‐Loaded PCL‐α‐TCP Fibrous Membranes for Bone Tissue Engineering

Alehosseini

Golafshan

Kharaziha

et al. 2018

Macromolecular Bioscience

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The combination of bioactive components such as calcium phosphates and fibrous structures are encouraging niche-mimetic keys for restoring bone defects. However, the importance of hemocompatibility of the membranes is widely ignored. Heparin-loaded nanocomposite poly(ε-caprolactone) (PCL)-α-tricalcium phosphate (α-TCP) fibrous membranes are developed to provide bioactive and hemocompatible constructs for bone tissue engineering. Nanocomposite membranes are optimized based on bioactivity, mechanical properties, and cell interaction. Consequently, various concentrations of heparin molecules are loaded within nanocomposite fibrous membranes. In vitro heparin release profiles reveal a sustained release of heparin over the period of 14 days without an initial burst. Moreover, heparin encapsulation enhances mesenchymal stem cell (MSC) attachment and proliferation, depending on the heparin content. It is concluded that the incorporation of heparin within TCP-PCL fibrous membranes provides the most effective cellular interactions through synergistic physical and chemical cues.

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Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Hemocompatible and Bioactive Heparin‐Loaded PCL‐α‐TCP Fibrous Membranes for Bone Tissue Engineering

Alehosseini

Golafshan

Kharaziha

et al. 2018

Macromolecular Bioscience

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Biomaterial Properties Modulating Bone Regeneration

Zhu

Goh

Shrestha

2021

Macromolecular Bioscience

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Biomaterial scaffolds have been gaining momentum in the past several decades for their potential applications in the area of tissue engineering. They function as three‐dimensional porous constructs to temporarily support the attachment of cells, subsequently influencing cell behaviors such as proliferation and differentiation to repair or regenerate defective tissues. In addition, scaffolds can also serve as delivery vehicles to achieve sustained release of encapsulated growth factors or therapeutic agents to further modulate the regeneration process. Given the limitations of current bone grafts used clinically in bone repair, alternatives such as biomaterial scaffolds have emerged as potential bone graft substitutes. This review summarizes how physicochemical properties of biomaterial scaffolds can influence cell behavior and its downstream effect, particularly in its application to bone regeneration.

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