Myrrh Inhibits LPS-Induced Inflammatory Response and Protects from Cecal Ligation and Puncture-Induced Sepsis

Kim, Min-Sun; Bae, Gi‐Sang; Park, Kyoung-Chel; Koo, Bon Soon; Kim, Byung‐Jin; Lee, Hye-Jin; Seo, Sang-Wan; Shin, Yong Kook; Jung, Won Yong; Cho, Jung-Hee; Kim, Youn‐Chul; Kim, Tae-Hyeon; Song, Ho‐Joon; Park, Sung‐Joo

doi:10.1155/2012/278718

Cited by 17 publications

(18 citation statements)

References 33 publications

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“…Thus, this extract has potential for the development of rheumatoid arthritis inhibitory therapies. Interestingly, as previous studies have demonstrated that C. molmol oleoresin extracts and essential oils also regulate cytokine production, 13 the methanolic myrrh extract, may well have similar prop erties and further studies are required to test this. If these extracts are subsequently found to modulate cytokine production, they may prove to be particularly useful for individuals suffering from rheumatoid arthritis, as they would provide both preventative and treatment mechanisms.…”

Section: Discussionmentioning

confidence: 95%

“…The myrrh extract may also have further effects on other phases of ankylosing spondylitis disease etiology. Indeed, it is possible that the extract may also modulate cytokine production and therefore also block later inflammatory disease events, 13 although this has yet to be tested for our extracts. Similarly, the methanolic myrrh extract also inhibited A. baylyi and P. aeruginosa growth, albeit with higher MIC values indicative of only moderate inhibition.…”

Section: Discussionmentioning

confidence: 99%

“…13 The same study reported that myrrh also inhibited cjun NH 2 terminal kinase (JNK), but did not affect extra cellular signal related kinase (ERK), p 38 and nuclear factorκB (NFκB). Furthermore, myrrh administration decreased leukocyte infiltration, providing evidence for a pleuripotent antiinflammatory mechanism.…”

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confidence: 97%

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GC-MS Analysis of Commiphora molmol Oleo-Resin Extracts which Inhibit the growth of Bacterial Triggers of Selected Autoimmune Diseases

Biggs¹,

Sirdaarta²,

White³

et al. 2016

Phcogj

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Introduction: Myrrh has been used traditionally for the inhibition of microbial growth and for the treatment of rheumatic diseases. Despite this, myrrh extracts are yet to be tested for the ability to inhibit the growth of the bacterial triggers of autoimmune inflammatory diseases. Methods: Solvent extracts prepared from commercially obtained myrrh resin were analysed for the ability to inhibit the growth of bacterial species associated with initiating rheumatoid arthritis (P. mirabilis), ankylosing spondylitis (K. pneumoniae) and multiple sclerosis (A. baylyi, P. aeruginosa) by disc diffusion assay, and quantified by MIC determination. Toxicity was determined by Artemia franciscana bioassay. The most potent inhibitory extract was investigated using non-targeted GC-MS head space analysis (with screening against a compound database) for the identification and characterisation of individual components in the crude plant extracts. Results: Methanolic myrrh extract inhibited the growth of all bacterial species tested. The growth inhibition of this extract was particularly notable against P. mirabilis and K. pneumoniae, with MIC values substantially < 1000 µg/mL for both reference and clinical bacterial strains. Indeed, the MIC values of the methanolic extract against P. mirabilis reference and clinical strains were 572 and 463 µg/mL respectively. The methanolic extract also inhibited the growth of A. baylyi (MIC approximately 3000 µg/mL) and P. aeruginosa (MIC approximately 1800 µg/mL). However, the MICs against these bacteria was indicative of only moderate inhibitory activity. The aqueous, ethyl acetate,

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Section: Discussionmentioning

confidence: 95%

Section: Discussionmentioning

confidence: 99%

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GC-MS Analysis of Commiphora molmol Oleo-Resin Extracts which Inhibit the growth of Bacterial Triggers of Selected Autoimmune Diseases

Biggs¹,

Sirdaarta²,

White³

et al. 2016

Phcogj

View full text Add to dashboard Cite

show abstract

“…In addition, myrrh inhibited CLP-induced production of IL-1β, IL-6, and TNF-α in mice serum and liver. These results suggest that myrrh may have antiinflammatory properties [46]. However, the effects and the mechanisms underlying anti-inflammatory activities of myrrh are poorly defined.…”

Section: Discussionmentioning

confidence: 95%

Role of Commiphora Mol Mol and Doxycycline in Prophylaxis of Spontaneous Bacterial Peritonitis in Egyptians Cirrhotic Patients

Mostafa¹,

Ibrahim²,

Badra³

et al. 2015

Am. J. Biomed. Sci.

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Aims: this study aimed to evaluate the role of commiphora mol mol and doxycycline in the prophylaxis of spontaneous bacterial peritonitis in cirrhotic patients. Methodology: sixty ascetic cirrhotic patients f r o m National Liver Institute, Menofiya University (Shebeen El-Kom-Egypt) with a history of at least one previous episode of SBP were included in blinded randomized clinical study. Patients were divided into four groups in a fashion; each group consists of 15 patients. Group one received ciprofloxacin (control group), group two received doxycycline, group three received commiphora mol mol and group four received a combination of commiphora mol mol and doxycycline for six months. Serum interleukin 6 (IL 6) and C Reactive Protein (CRP) level were the primary inflammatory markers of the study to evaluate the effect of the studied medications. Results: both IL-6 and CRP levels showed significant decrease three and six months after treatment in all studied groups (P<0.05). Group four showed a significant decrease in IL 6 and CRP level compared with other three groups (P<0.05). Conclusion: the results of the current study strongly support the efficacy of doxycycline and Commiphora molmol as a primary prophylactic therapy in patients with SBP. Furthermore, commiphora mol mol/doxycycline combination was the most effective and showed synergistic effect which may be useful in decrease emergence of resistant strains.

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“…Medicinal plants have been investigated to be effective as natural treatment for sepsis-induced by CLP [11][12][13][14] . Most plants contain several compounds with antimicrobial properties for protection against aggressor agents, especially microorganisms 1 .…”

Section: Introductionmentioning

confidence: 99%

Effect of γ-Irradiation on the Antibacterial Activities ofCuminum cyminum L.Essential OilsIn VitroandIn VivoSystems

Reza

Atefeh

Fatemi

2015

Journal of Essential Oil Bearing Plants

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The present study was carried out to investigate the effect of γ-irradiation at two irradiation doses of 10 and 25 kGy, on the antibacterial activities of cumin essential oils (E.Os) in vitro and in vivo systems. For this purpose, the cumin seeds were irradiated with Co 60 source (0, 10 and 25 kGy) and subjected to Clevenger extraction to obtain E.Os. In vitro antibacterial activities of cumin E.Os was determined on Gram-negative and Gram-positive bacterial strains including E. coli, P. aeroginosa, B. cereus and S. aureus using agar well diffusion method, disk diffusion method and, MIC and MBC determinations. In vivo antibacterial activity was performed on polymicrobial infection induced by cecal ligation and puncture (CLP) in rat through blood colony forming units (CFUs) determination. The results showed that CLP operation caused a marked increase in bacterial load of blood which was reduced in rats treated with fresh and irradiated cumin oils. In vitro results also showed the sensitivity of all tested bacterial strains against the fresh and irradiated cumin E.Os. These data may suggest that cumin E.O has potential antibacterial activity both in vivo and in vitro systems. Also, γ-irradiation to cumin seeds at 10 and 25 kGy has no significant effects on the antibacterial properties of cumin E.Os.

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Myrrh Inhibits LPS-Induced Inflammatory Response and Protects from Cecal Ligation and Puncture-Induced Sepsis

Cited by 17 publications

References 33 publications

GC-MS Analysis of Commiphora molmol Oleo-Resin Extracts which Inhibit the growth of Bacterial Triggers of Selected Autoimmune Diseases

GC-MS Analysis of Commiphora molmol Oleo-Resin Extracts which Inhibit the growth of Bacterial Triggers of Selected Autoimmune Diseases

Role of Commiphora Mol Mol and Doxycycline in Prophylaxis of Spontaneous Bacterial Peritonitis in Egyptians Cirrhotic Patients

Effect of γ-Irradiation on the Antibacterial Activities ofCuminum cyminum L.Essential OilsIn VitroandIn VivoSystems

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