Role of Commiphora Mol Mol and Doxycycline in Prophylaxis of Spontaneous Bacterial Peritonitis in Egyptians Cirrhotic Patients

Abstract

Aims: this study aimed to evaluate the role of commiphora mol mol and doxycycline in the prophylaxis of spontaneous bacterial peritonitis in cirrhotic patients. Methodology: sixty ascetic cirrhotic patients f r o m National Liver Institute, Menofiya University (Shebeen El-Kom-Egypt) with a history of at least one previous episode of SBP were included in blinded randomized clinical study. Patients were divided into four groups in a fashion; each group consists of 15 patients. Group one received ciprofloxacin (control group), group two received doxycycline, group three received commiphora mol mol and group four received a combination of commiphora mol mol and doxycycline for six months. Serum interleukin 6 (IL 6) and C Reactive Protein (CRP) level were the primary inflammatory markers of the study to evaluate the effect of the studied medications. Results: both IL-6 and CRP levels showed significant decrease three and six months after treatment in all studied groups (P<0.05). Group four showed a significant decrease in IL 6 and CRP level compared with other three groups (P<0.05). Conclusion: the results of the current study strongly support the efficacy of doxycycline and Commiphora molmol as a primary prophylactic therapy in patients with SBP. Furthermore, commiphora mol mol/doxycycline combination was the most effective and showed synergistic effect which may be useful in decrease emergence of resistant strains.

Assessment and Comparison of the Skin Irritation Potential of Five Plant Extracts Using In Vitro and In Vivo Methods

“…Fibroblasts play important roles in maintaining cell morphological and physiological characteristics, as well as in regulating the physiological function of skin. Research has shown that fibroblasts in derma can secrete various cytokines and extracellular matrix components, which function in regulating cell growth, proliferation, differentiation, and migration [8][9]. Additionally, fibroblasts can secrete inflammatory factors that influence skin irritation, allowing fibroblasts to be utilized in a highly sensitive assay to predict the potential for human skin irritation [10].…”