Myo-inositol is a promising treatment for the prevention of ovarian hyperstimulation syndrome (OHSS): an animal study

Abstract

PurposeTo evaluate the efficacy of myo-inositol (MI) pretreatment in OHSS.MethodsIn this experimental OHSS rat model, 42 immature Wistar albino female rats were divided into 6 groups: (1) the control group, (2) the ovarian stimulation group, (3) the OHSS group, (4) the OHSS + Metformin group, (5) OHSS + MI group, (6) OHSS + Metformin + MI group. OHSS was established after treatment with metformin and myo-inositol for 14 days, in the meanwhile the treatment of metformin and myo-inositol was also continued. All animals were killed 48 h after hCG administration and were compared in terms of vascular permeability, ovarian weight and diameter, ovarian VEGF, COX-2 and PEDF expression (immunohistochemistry), serum PEDF and estradiol (E2) levels.ResultsVascular permeability, VEGF and COX-2 expressions were reduced in animals treated with MI and/or metformin. While PEDF expression was increased in the groups taking metformin, there was no difference in PEDF expression in the group taking MI and OHSS group. There was no significant difference in serum PEDF levels between groups. Blood E2 levels were decreased in groups treated with MI or metformin compared to the OHSS group.ConclusionsOur data demonstrate that myo-inositol is effective in preventing OHSS, similar to metformin. Although the two drugs are thought to act through distinct mechanisms, there is no apparent benefit to co-treatment with both drugs in an animal model of OHSS. Administration of myo-inositol prior to IVF treatment may favor the control of ovulation induction. Further studies are necessary to elucidate the mechanism of action and further support our findings.

Inositol and In Vitro Fertilization with Embryo Transfer

“…Recent trials point out that MYO is effective in preventing OHSS in a way similar to metformin [32]. …”

Synthesis, thermal studies and conversion degree of dimethacrylate polymers using new non-toxic coinitiators

“…It is also used to treat women with polycystic ovary syndrome and children with respiratory distress syndrome, attesting non-toxic activity. [16][17][18][19][20][21] In the study of these dimethacrylate resins it is important to understand their thermal behavior, thus Thermoanalytical techniques such as Simultaneous Thermogravimetric Analysis -Differential Thermal Analysis (TGA-DTA) and Differential Scanning Calorimetry (DSC) are used in order to determine their thermal stability, degradation steps, glass transition, crystalline transition, crystallization, melt, and polymer cure. [22][23][24][25][26][27][28] Another important point is to study the dimethacrylate monomers' conversion, using different initiators systems.…”

A unique variant of spontaneous ovarian hyperstimulation syndrome: case report

“…Vascular permeability, VEGF, E-2 levels and cox-2 expression were reduced in animals treated with MI and/or metformin and inositol was effective in preventing OHSS similar to metformin. 10 Paplaeo et al observed lower E2 level on HCG day in the individuals receiving MI. Based on this finding they commented that MI reduces the risk of OHSS.…”