2017
DOI: 10.1155/2017/5469409
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Inositol and In Vitro Fertilization with Embryo Transfer

Abstract: Recently, studies on inositol supplementation during in vitro fertilization program (IVF) have gained particular importance due to the effect of this molecule on reducing insulin resistance improving ovarian function, oocyte quality, and embryo and pregnancy rates and reducing gonadotropin amount during stimulation. Inositol and its isoforms, especially myoinositol (MYO), are often used as prestimulation therapy in infertile patients undergoing IVF cycle. Inositol supplementation started three months before ov… Show more

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Cited by 21 publications
(16 citation statements)
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References 34 publications
(47 reference statements)
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“…This MI depletion eventually leads to poor oocyte quality (Carlomagno et al, 2011). MI supplementation may salvage the situation by improving oocyte quality (Simi et al, 2017).…”
Section: Discussionmentioning
confidence: 99%
“…This MI depletion eventually leads to poor oocyte quality (Carlomagno et al, 2011). MI supplementation may salvage the situation by improving oocyte quality (Simi et al, 2017).…”
Section: Discussionmentioning
confidence: 99%
“…Women receiving MI required a significantly lower total dose of gonadotropins for stimulation, which reduced the risk of ovarian hyperstimulation syndrome. In those patients who were prepared for extracorporeal fertilization programs, who received MI and DCI, had higher quality of oocytes and embryos, as well as a greater number of reported pregnancies after the transfer [11,71].…”
Section: Cyclitols Polycystic Ovary Syndrome (Pcos) and Fertilitymentioning
confidence: 99%
“…Myo-Inositol (MI) was demonstrated to exert beneficial effects on overweight/obese women with polycystic ovary syndrome (PCOS), being able to increase mature oocytes yield, oocyte nuclear and cytoplasmic maturation, and finally embryo development [ 11 , 39 ], probably due to its capacity to provide metabolites able to mediate insulin action [ 40 ]. However, MI effects on pregnancy and live birth rates after IVF are still a matter of debate [ 41 ].…”
Section: Discussionmentioning
confidence: 99%