Inositol and In Vitro Fertilization with Embryo Transfer

Simi, Giovanna; Genazzani, Ar; Obino, Maria Elena Rosa; Papini, Francesca; Pinelli, Sara; Cela, Vito; Artini, Paolo Giovanni

doi:10.1155/2017/5469409

Cited by 21 publications

(16 citation statements)

References 34 publications

(47 reference statements)

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“…This MI depletion eventually leads to poor oocyte quality (Carlomagno et al, 2011). MI supplementation may salvage the situation by improving oocyte quality (Simi et al, 2017).…”

Section: Discussionmentioning

confidence: 99%

Myo-Inositol and Its Derivatives: Their Emerging Role in the Treatment of Human Diseases

Chhetri

2019

Front. Pharmacol.

130

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Myo-inositol has been established as an important growth-promoting factor of mammalian cells and animals. The role of myo-inositol as a lipotropic factor has been proven, in addition to its involvement as co-factors of enzymes and as messenger molecules in signal transduction. Myo-inositol deficiency leads to intestinal lipodystrophy in animals and “inositol-less death” in some fungi. Of late, diverse uses of myo-inositol and its derivatives have been discovered in medicinal research. These compounds are used in the treatment of a variety of ailments from diabetes to cancer, and continued research in this direction promises a new future in therapeutics. In different diseases, inositols implement different strategies for therapeutic actions such as tissue specific increase or decrease in inositol products, production of inositol phosphoglycans (IPGs), conversion of myo-inositol (MI) to D-chiro-inositol (DCI), modulation of signal transduction, regulation of reactive oxygen species (ROS) production, etc. Though inositol pharmacology is a relatively lesser-known field, recent years of research has generated a critical mass of information on the subject. This review aims to summarize our current understanding on the role of inositol derivatives in ameliorating the symptoms of different diseases.

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“…This MI depletion eventually leads to poor oocyte quality (Carlomagno et al, 2011). MI supplementation may salvage the situation by improving oocyte quality (Simi et al, 2017).…”

Section: Discussionmentioning

confidence: 99%

Myo-Inositol and Its Derivatives: Their Emerging Role in the Treatment of Human Diseases

Chhetri

2019

Front. Pharmacol.

130

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“…Women receiving MI required a significantly lower total dose of gonadotropins for stimulation, which reduced the risk of ovarian hyperstimulation syndrome. In those patients who were prepared for extracorporeal fertilization programs, who received MI and DCI, had higher quality of oocytes and embryos, as well as a greater number of reported pregnancies after the transfer [11,71].…”

Section: Cyclitols Polycystic Ovary Syndrome (Pcos) and Fertilitymentioning

confidence: 99%

The Healing-Promoting Properties of Selected Cyclitols—A Review

et al. 2018

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Introduction: Myo-inositol and its derivatives cyclitols play an important role in the processes of cell regulation, signal transduction, osmoregulation, and ion channel physiology, and are a component of the cell membrane. Free cyclitols present in food or released during the degradation of galactosyl cyclitols by bacteria (in digestive tract) show some physiological benefits. Aim: The aim of this paper is to present and analyze the documented data about curative and healing properties of cyclitols. Results and discussion: Cyclitols are well known compounds in the treatment of an accompanied diabetes insulin resistance, and also obesity and polycystic ovarian syndrome. d-chiro-Inositol deficiency exacerbates insulin resistance in the liver, muscles, and fat, while depletion of myo-inositol results in the development of diabetic complications. Cyclitols are successfully applied in treatment of polycystic ovarian syndrome, simultaneous are observed effective reducing of BMI, improving the hormonal profile, and increasing fertility. Moreover, cyclitols have anti-atherogenic, anti-oxidative, anti-inflammatory, and anti-cancer properties. Conclusion: The properties of cyclitols may be a good therapeutic option in the reduction of metabolically induced inflammation. Due to well drugs tolerance and low toxicity of these compounds, cyclitols are recommend for pregnant women and also for children. Another advantage is their widespread presence and easy availability, which encourages their use in medicine.

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“…Myo-Inositol (MI) was demonstrated to exert beneficial effects on overweight/obese women with polycystic ovary syndrome (PCOS), being able to increase mature oocytes yield, oocyte nuclear and cytoplasmic maturation, and finally embryo development [ 11 , 39 ], probably due to its capacity to provide metabolites able to mediate insulin action [ 40 ]. However, MI effects on pregnancy and live birth rates after IVF are still a matter of debate [ 41 ].…”

Section: Discussionmentioning

confidence: 99%

Effect of a Combination of Myo-Inositol, Alpha-Lipoic Acid, and Folic Acid on Oocyte Morphology and Embryo Morphokinetics in non-PCOS Overweight/Obese Patients Undergoing IVF: A Pilot, Prospective, Randomized Study

Canosa

Paschero

Carosso

et al. 2020

JCM

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Herein we aimed at assessing whether Myo-Inositol (MI), Alpha–Lipoic acid (ALA), and Folic acid (FA) could improve oocyte quality and embryo development in non-PCOS overweight/obese women undergoing IVF. Three hundred and twenty-four mature oocytes were obtained from non-PCOS overweight/obese patients, randomized to receive either MI, ALA, and FA (MI + ALA + FA group, n = 155 oocytes) or FA alone (FA-only group, n = 169 oocytes). Oocytes were examined using Polarized Light Microscopy to assess morphological features of zona pellucida (ZP) and meiotic spindle (MS). One hundred and seventy-six embryos (n = 84 in the MI + ALA + FA group, n = 92 in the FA-only group) were assessed by conventional morphology on days 2 and 5, as well as using the Time-Lapse System morphokinetic analysis. A significantly higher ZP retardance, area, and thickness (p < 0.05), and a shorter MS axis (p < 0.05) were observed in the MI + ALA + FA group, suggesting a positive effect on oocyte quality. Conventional morphology evaluation on day 2 showed a higher mean embryo score in the MI + ALA + FA group, whereas embryo morphokinetic was comparable in the two groups. Overall, our data show a possible beneficial effect of the combination of MI, ALA, and FA on oocyte and embryo morphology, encouraging testing of this combination in adequately powered randomized trials to assess their impact of clinical IVF results.

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Inositol and In Vitro Fertilization with Embryo Transfer

Cited by 21 publications

References 34 publications

Myo-Inositol and Its Derivatives: Their Emerging Role in the Treatment of Human Diseases

Myo-Inositol and Its Derivatives: Their Emerging Role in the Treatment of Human Diseases

The Healing-Promoting Properties of Selected Cyclitols—A Review

Effect of a Combination of Myo-Inositol, Alpha-Lipoic Acid, and Folic Acid on Oocyte Morphology and Embryo Morphokinetics in non-PCOS Overweight/Obese Patients Undergoing IVF: A Pilot, Prospective, Randomized Study

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