Muntingia calabura fruits as sources of bioactive compounds and fermentative ethanol production

Nasution, Fitriana; Theanhom, Araya Arjcharoen; Unpaprom, Yuwalee; Ramaraj, Rameshprabu; Manmai, Numchok; Chumpookam, J.

doi:10.1007/s13399-022-02465-6

Cited by 9 publications

(6 citation statements)

References 36 publications

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“…In this study, MIC and MBC values of E. coli and B. subtilis were 10 mg/mL and 20 mg/mL respectively. From the finding, M. calabura fruit extract can be considered as weak bacteria inhibitor [27]. Low value could be explained because of the presence of various phytochemical compounds, f o r e x a m p l e polyphenolics which interferes the antimicrobial activity of the extract.…”

Section: Fig 3 Ftir Spectrum Of M Calabura Methanolic Fruit Extractmentioning

confidence: 99%

“…Low value could be explained because of the presence of various phytochemical compounds, f o r e x a m p l e polyphenolics which interferes the antimicrobial activity of the extract. Moreover, the compounds might exert antagonistic effect on the bioactive compounds that perform antimicrobial activity [27]. Further optimization on M. calabura extraction is suggested to ensure pure target phytochemicals could be obtained for efficient antimicrobial activity.…”

Section: Fig 3 Ftir Spectrum Of M Calabura Methanolic Fruit Extractmentioning

confidence: 99%

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Phytochemical Screening of Muntingia Calabura Fruit for Antioxidant and Cytotoxic Activities

Muniyappan

Adenam

et al. 2022

ARASET

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Muntingia calabura (M. calabura) is an indigenous fruit species that is widely distributed in Malaysia and traditionally believed for constituting medicinal properties, yet little-known and underutilized. Hence, this study aimed to perform an extraction of M. calabura fruit to identify phytochemicals potential by carrying out several analysis such as Total Phenolic Content, Fourier Transform Infrared Spectrum (FTIR), High Performance Liquid Chromatography (HPLC) and 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical scavenging assay. Besides, the antioxidant and cytotoxicity properties of M. calabura were also identified from Minimum Inhibitory Concentration (MIC), Minimum Bactericidal Concentration (MBC) and brine shrimp lethality tests. The finding suggested that further study on the modification of M. calabura extraction should be carried out to explore maximal potential of M. calabura as natural medicine and commercial use .

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Section: Fig 3 Ftir Spectrum Of M Calabura Methanolic Fruit Extractmentioning

confidence: 99%

Section: Fig 3 Ftir Spectrum Of M Calabura Methanolic Fruit Extractmentioning

confidence: 99%

Phytochemical Screening of Muntingia Calabura Fruit for Antioxidant and Cytotoxic Activities

Muniyappan

Adenam

et al. 2022

ARASET

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“…[15][16][17] Muntingia calabura, popularly known as calabura, is found in Brazil and Asia, in countries such as China and the Philippines. 18,19 Calabura is considered to be a fruit with high amounts of phenolic compounds and antioxidants, 20,21 which arouses interest in the investigation of this species in health and food research.…”

Section: Introductionmentioning

confidence: 99%

Optimization of the extraction of bioactive compounds from Muntingia calabura peels and cytotoxic and antiproliferative evaluation by the Allium cepa test

Silva

Aranha

Reis

et al. 2022

J of Chemical Tech & Biotech

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Objective and Methods The purpose of this article was to compare the extraction efficiency of bioactive compounds from Muntingia calabura peel using conventional methodology and ultrasound assistance, in addition, to verify the best extraction conditions, varying the drying temperature of the peels, time and solvents, and then to verify the cytotoxic and antiproliferative action of M. calabura extracts by Allium cepa. Results and Conclusions It was verified through the analysis of total phenolic compounds, 2,2′‐azino‐bis(3‐ethylbenzothiazoline‐6‐sulfonic acid (ABTS) and iron reduction capacity that the best conditions were ultrasonic extraction, with a temperature of 50 °C, 50% aqueous ethanol solution and extraction time of 60 min. Regarding the quantification of total phenolic compounds (TPC), ABTS and ferric reducing antioxidant power (FRAP) in calabura peel, there was a variation of 571.33–1444.67 mg GAE (gallic acid equivalents) 100 g−1 dry peel for TPC, 19.36–115.74 mg Trolox 100 g−1 for ABTS and 306.73–1608.97 for FRAP. Regarding the cytotoxic effect on root growth of A. cepa, it was found that both conventional and ultrasound‐assisted extraction had an effect on onion root growth. In addition, together with the results of the analyzed cells and the literature, it can be verified that M. calabura peels also have an antiproliferative effect. This effect is due to the high concentration of phenolic compounds found in the analyzed extracts; such bioactive compounds are responsible for inhibiting cell division in meristematic cells. © 2022 Society of Chemical Industry (SCI).

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“…In recent years, there has been growing interest in plant-based preparations derived from wild plants. Preparations topically applied to the skin (apart from their antioxidant activity, which is extremely important in the prevention of cell aging processes) are characterized by antimicrobial activity against pathogenic microorganisms occurring on the skin [ 5 , 6 , 10 , 11 , 12 , 13 , 14 , 15 , 16 ].…”

Section: Introductionmentioning

confidence: 99%

“…It is clear that most green plants, vegetables, and fruits are major sources of natural antioxidants. Consuming these antioxidants in the human diet is a reasonable way to reduce brain dysfunction, cardio-vascular disease, cataracts, and risk of cancers [ 11 , 13 , 14 , 20 , 21 , 22 , 23 , 24 , 25 , 26 , 27 , 28 , 29 , 30 , 31 , 32 ].…”

Section: Introductionmentioning

confidence: 99%

Biologically Active Preparations from the Leaves of Wild Plant Species of the Genus Rubus

et al. 2022

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The plants of the genus Rubus (R.) are applied as antiseptic agents in the treatment of skin diseases. Despite the great interest in plants of this genus, there are few reports on the antioxidant and biological activities of preparations obtained from the leaves of these plants. Therefore, we decided to evaluate the antioxidant activity of preparations from leaves of wild plant species of the genus Rubus using the frequently applied DPPH, ABTS, and FRAP methods, as well as to determine the total polyphenol content using the Folin–Ciocalteau method and perform qualitative evaluation by gas chromatography–mass spectrometry (GC-MS). The bactericidal and fungicidal activities of the obtained preparations were evaluated by applying laboratory tests: using the disc and the well methods based on the standards EN 13697:2019, EN 13697:2015, and EN 1500:2013. Microbiological tests of the plant preparations against bacteria, fungi, and yeasts isolated from the environment and against reference strains were performed. Moreover, antimicrobial testing of antibiotics against the tested strains was performed for comparison. The n-octanol/water partition coefficient of the obtained preparations was determined by the shake-flask method to determine their lipophilicity. According to the results, a high content of polyphenols and other antioxidant and biologically active compounds can be thought of as the parameter responsible for the effective activity of plant preparations obtained from wild plant species of the genus Rubus. The methods for determining bactericidal and fungicidal activity clearly demonstrates that preparations with reduced ethanol content exhibit bactericidal and fungicidal activity on surfaces. Testing of hand disinfection by means of rubbing with the preparations confirmed their antimicrobial activity against Escherichia coli K12 NCTC 10538. The obtained results show that the tested preparations exhibit on average two times lower activity against the reference bacterial strains than comparable antibiotics. The preparations obtained from the leaves of R. idaeus L. and R. fruticosus L. could complement classical antibiotics. While environmental bacteria showed a similar response to the preparations and antibiotics, their sensitivity was about one-third less than that of the reference strains. Our studies have shown that the obtained preparations are highly hydrophilic (logP < 0). Thus, these preparations can only be used in lipid bilayers in the aqueous core of liposomes, not in the lipid envelope.

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Muntingia calabura fruits as sources of bioactive compounds and fermentative ethanol production

Cited by 9 publications

References 36 publications

Phytochemical Screening of Muntingia Calabura Fruit for Antioxidant and Cytotoxic Activities

Phytochemical Screening of Muntingia Calabura Fruit for Antioxidant and Cytotoxic Activities

Optimization of the extraction of bioactive compounds from Muntingia calabura peels and cytotoxic and antiproliferative evaluation by the Allium cepa test

Biologically Active Preparations from the Leaves of Wild Plant Species of the Genus Rubus

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