Multivariate calibration applied to the time-resolved chemilumnescence for the simultaneous determination of morphine and its antagonist naloxone

Pulgarı́n, José A. Murillo; Bermejo, Luisa F. García; García, M. Nieves Sánchez

doi:10.1016/j.aca.2007.09.018

Cited by 35 publications

(14 citation statements)

References 22 publications

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“…Recently, several flow injection (FI) methods for the determination of paracetamol have been proposed using an UV-Vis spectrophotometer [20][21][22], fluorimeter [23], multioptosensor [24], or Fourier transform infrared spectrophotometer [25] as a detector.…”

Section: Introductionmentioning

confidence: 99%

Rapid and accurate amperometric determination of acetaminophen in pharmaceutical preparations and spiked human blood serum samples at cadmium pentacyanonitrosylferrate modified glassy carbon electrode

Razmi

Harasi

2008

JICS

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The present work describes a rapid and accurate amperometric technique for the determination of acetaminophen (ACT) in pharmaceutical preparations and human blood serum, based on electrocatalytic oxidation of ACT at a glassy carbon electrode modified by cadmium pentacyanonitrosylferrate (CdPCNF) film. The electrocatalytic response of the modified GC electrode was linear over the concentration of 1.64-52.90 μM. The limit of detection was found to be 2.04 μM by amperometric technique. The method was successfully utilized for the determination of ACT in various pharmaceutical preparations and the results have been statistically compared with those obtained by the official method. The interference of some pharmaceutical and biological compounds was investigated. The results of interference study showed that the Nafion-coated CdPCNF|GC electrode can be utilized as a selective amperometric sensor for acetaminophen determination in human blood serum. The mean value of rate constant k for catalytic reaction, and the diffusion coefficient of ACT (D) in the phosphate buffer solution of pH 7.2 were found to be 4.27 10 2 M -1 s -1 , and (4.25 ± 0.33) 10 -6 cm 2 s -1 , respectively.

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Section: Introductionmentioning

confidence: 99%

Rapid and accurate amperometric determination of acetaminophen in pharmaceutical preparations and spiked human blood serum samples at cadmium pentacyanonitrosylferrate modified glassy carbon electrode

Razmi

Harasi

2008

JICS

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“…These include capillary electrophoresis, 18 fluorimetry, 19 titrimetry, 20 flow injection analysis (FIA) (using different methods of detection), 21 liquid chromatography, 22 spectrophotometry, 23 spectrofluorometry 24 and chemiluminescence. 25 For the determination of Tramadol itself, fewer analytical methodologies have been proposed.…”

Section: Introductionmentioning

confidence: 99%

A multi-walled carbon nanotube-modified glassy carbon electrode as a new sensor for the sensitive simultaneous determination of paracetamol and tramadol in pharmaceutical preparations and biological fluids

Babaei¹,

Taheri²,

Afrasiabi³

2011

J. Braz. Chem. Soc.

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Um eletrodo modificado quimicamente foi construído, baseado em eletrodo de carbono vítreo modificado por nanotubos de carbono de parede múltipla (MWCNTs/GCE). Demonstrou-se que este sensor pode ser usado para a determinação simultânea de compostos com importância farmacêutica, como o paracetamol (PAR) e o tramadol (TRA). As medidas foram realizadas com aplicação de voltametria de pulso diferencial (DPV), voltametria cíclica (CV) e cronoamperometria (CA). A aplicação do método DPV demonstrou que em tampão fosfato (pH 7,5) há uma relação linear entre a corrente de pico de oxidação e a concentração de PAR no intervalo entre 0,5 μmol L -1 e 210 μmol L -1 . Uma correlação linear semelhante, entre a corrente de pico de oxidação e a concentração, foi observada para TRA no intervalo de 2 μmol L -1 a 300 μmol L -1 . Sob condições ótimas, o eletrodo modificado exibiu alta sensibilidade, seletividade e estabilidade para a determinação de ambos, PAR e TRA, tornando este, um sensor adequado para a detecção submicromolar simultânea de PAR e TRA, em soluções. O desempenho analítico deste sensor foi avaliado para detecção de PAR e TRA em soro e urina humanos e em algumas preparações farmacêuticas, com resultados satisfatórios.A chemically modified electrode was constructed based on a multi-walled carbon nanotubemodified glassy carbon electrode (MWCNTs/GCE). It was demonstrated that this sensor can be used for the simultaneous determination of the pharmaceutically important compounds paracetamol (PAR) and tramadol (TRA). The measurements were carried out by the application of differential pulse voltammetry (DPV), cyclic voltammetry (CV) and chronoamperometry (CA) methods. Application of the DPV method demonstrated that in phosphate buffer (pH 7.5) there was a linear relationship between the oxidation peak current and the concentration of PAR over the range 0.5 μmol L -1 to 210 μmol L -1. A similar linear correlation between oxidation peak current and concentration was observed for TRA over the range of 2 μmol L -1 to 300 μmol L -1. Under optimal conditions the modified electrode exhibited high sensitivity, selectivity and stability for both PAR and TRA determination, making it a suitable sensor for the simultaneous submicromolar detection of PAR and TRA in solutions. The analytical performance of this sensor has been evaluated for detection of PAR and TRA in human serum, human urine and some pharmaceutical preparations with satisfactory results.

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“…A stopped-flow method with fluorescence detection for the determination of PCT based on its oxidation with hexacyanoferrate(III), is described [172]. A kinetic study of the reaction is developed measuring the initial rate of change of the fluorescence intensity of the oxidised product formed at 241 and 426 nm excitation and emission wavelengths, respectively.…”

Section: Spectrofluorimetric Methodsmentioning

confidence: 99%

Determination of paracetamol: Historical evolution

Bosch

Ruiz-Sánchez

Rojas

et al. 2006

Journal of Pharmaceutical and Biomedical Analysis

214

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Multivariate calibration applied to the time-resolved chemilumnescence for the simultaneous determination of morphine and its antagonist naloxone

Cited by 35 publications

References 22 publications

Rapid and accurate amperometric determination of acetaminophen in pharmaceutical preparations and spiked human blood serum samples at cadmium pentacyanonitrosylferrate modified glassy carbon electrode

Rapid and accurate amperometric determination of acetaminophen in pharmaceutical preparations and spiked human blood serum samples at cadmium pentacyanonitrosylferrate modified glassy carbon electrode

A multi-walled carbon nanotube-modified glassy carbon electrode as a new sensor for the sensitive simultaneous determination of paracetamol and tramadol in pharmaceutical preparations and biological fluids

Determination of paracetamol: Historical evolution

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