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Ion-imprinted polymer (IIP) technology has received considerable attention for its greatest potential application. In this work, a novel magnetic nano ion-imprinted polymer (MIIP) for the selective and sensitive pre-concentration of silver (I) ions were used. It was obtained using Fe3O4@SiO2@TiO2 nanoparticles as a magnetic support of adsorbent, Ag(I)-2,4-diamino-6-phenyl-1,3,5-triazine (DPT) complex as the template molecule and methacrylic acid (MAA), 2,2′-azobisisobutyronitrile (AIBN), ethylene glycol dimethacrylate (EGDMA), as the functional monomer, the radical initiator and crosslinker, respectively. The synthesized polymer nanoparticles were characterized by X-ray diffraction (XRD), scanning electron microscopy-energy-dispersive X-ray spectroscopy (SEM-EDS), transmission electron microscopy (TEM), vibrating sample magnetometer (VSM) and Brunauer-Emmett-Teller (BET). Silver ions were separate from the polymer and measured by flame atomic absorption spectrometry (FAAS). The maximum adsorption capacity of the novel imprinted adsorbent for Ag(I) was calculated to be 62.5 mg g−1. The developed method was applied to the preconcentration of the analyte in the water, radiology film and food samples, and satisfactory results were obtained.

Um eletrodo modificado quimicamente foi construído, baseado em eletrodo de carbono vítreo modificado por nanotubos de carbono de parede múltipla (MWCNTs/GCE). Demonstrou-se que este sensor pode ser usado para a determinação simultânea de compostos com importância farmacêutica, como o paracetamol (PAR) e o tramadol (TRA). As medidas foram realizadas com aplicação de voltametria de pulso diferencial (DPV), voltametria cíclica (CV) e cronoamperometria (CA). A aplicação do método DPV demonstrou que em tampão fosfato (pH 7,5) há uma relação linear entre a corrente de pico de oxidação e a concentração de PAR no intervalo entre 0,5 μmol L -1 e 210 μmol L -1 . Uma correlação linear semelhante, entre a corrente de pico de oxidação e a concentração, foi observada para TRA no intervalo de 2 μmol L -1 a 300 μmol L -1 . Sob condições ótimas, o eletrodo modificado exibiu alta sensibilidade, seletividade e estabilidade para a determinação de ambos, PAR e TRA, tornando este, um sensor adequado para a detecção submicromolar simultânea de PAR e TRA, em soluções. O desempenho analítico deste sensor foi avaliado para detecção de PAR e TRA em soro e urina humanos e em algumas preparações farmacêuticas, com resultados satisfatórios.A chemically modified electrode was constructed based on a multi-walled carbon nanotubemodified glassy carbon electrode (MWCNTs/GCE). It was demonstrated that this sensor can be used for the simultaneous determination of the pharmaceutically important compounds paracetamol (PAR) and tramadol (TRA). The measurements were carried out by the application of differential pulse voltammetry (DPV), cyclic voltammetry (CV) and chronoamperometry (CA) methods. Application of the DPV method demonstrated that in phosphate buffer (pH 7.5) there was a linear relationship between the oxidation peak current and the concentration of PAR over the range 0.5 μmol L -1 to 210 μmol L -1. A similar linear correlation between oxidation peak current and concentration was observed for TRA over the range of 2 μmol L -1 to 300 μmol L -1. Under optimal conditions the modified electrode exhibited high sensitivity, selectivity and stability for both PAR and TRA determination, making it a suitable sensor for the simultaneous submicromolar detection of PAR and TRA in solutions. The analytical performance of this sensor has been evaluated for detection of PAR and TRA in human serum, human urine and some pharmaceutical preparations with satisfactory results.