Multiresidue determination of veterinary drugs in aquaculture fish samples by ultra high performance liquid chromatography coupled to tandem mass spectrometry

Lopes, Renata Pereira; Reyes, Rocío Cazorla; Romero‐González, Roberto; Vidal, José Luis Martı́nez

doi:10.1016/j.jchromb.2012.03.011

Cited by 117 publications

(56 citation statements)

References 36 publications

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“…Acetonitrile is known to be frequently applied to multiresidue analysis due to its high extraction efficiency [22][23][24]. Considering that 6-Ch has an acid carboxyl group, an extraction agent with acid added (acetonitrile with 0.2% FA addition) was compared with acetonitrile to acquire a satisfactory recovery.…”

Section: Optimization Of Extraction Agent and Dspe Cleanup Processmentioning

confidence: 99%

Simultaneous determination of flupyradifurone and its two metabolites in fruits, vegetables, and grains by a modified quick, easy, cheap, effective, rugged, and safe method using ultra high performance liquid chromatography with tandem mass spectrometry

Liu

et al. 2016

J of Separation Science

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An effective analytical method for the simultaneous determination of a novel insecticide flupyradifurone and its two metabolites was developed using ultra high performance liquid chromatography with tandem mass spectrometry coupled with a quick, easy, cheap, effective, rugged, and safe procedure. The three target compounds were extracted with acetonitrile and cleaned up with octadecylsilane, and were separated successfully between 1.9 and 3.1 min using an HSS T3 chromatographic column connected to an electrospray ionization source. All the matrix-matched samples at three fortified levels (0.01, 0.05, and 0.5 mg/kg) provided satisfactory recoveries in the range of 70.3-116.5% with relative standard deviations below 18.6%. The limits of quantitation were 10 μg/kg for flupyradifurone and difluoroethylamino-furanone and 100 μg/kg for 6-chloronicotinic acid. The limit of quantification of flupyradifurone was far below the maximum residue limit in the USA. The method is of great significance for establishing maximum residue limits in China.

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Section: Optimization Of Extraction Agent and Dspe Cleanup Processmentioning

confidence: 99%

Simultaneous determination of flupyradifurone and its two metabolites in fruits, vegetables, and grains by a modified quick, easy, cheap, effective, rugged, and safe method using ultra high performance liquid chromatography with tandem mass spectrometry

Liu

et al. 2016

J of Separation Science

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“…Another technique that has been highlighted for the extraction and purification of antibiotics in biological matrices is QuEChERS (quick, easy, cheap, effective, rugged, and safe), which was initially developed by Anastassiades et al [145] for the determination of pesticide residues in food. It has been adapted and has been used for the determination of other compounds, including antibiotics in fish [54,146].…”

Section: Sample Preparation Techniquesmentioning

confidence: 99%

Veterinary Antibiotics in the Environment

Botelho¹,

Monteiro²,

LuizTornisielo³

2015

Emerging Pollutants in the Environment - Current and Further Implications

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In recent years, pharmaceutical pollution in the environment has been a great concern due to the potential effects on the human and animal health. Some of the most used classes such as antibiotics, which are used to prevent and treat bacterial infections and promote the growth of livestock, deserve to be highlighted since their intensive use has contaminated environmental matrices such as soil, water, sediment, plants, and animals with effects on the biota. To better understand the potential ecological risk of antibiotics in environments and to develop management strategies for these substances searching to reach the reduction of these compounds in aquatic systems, one of the most important steps is to determine the environmental concentrations of these compounds in the environments through analytical methods and evaluate their effects on the biota. The goal of this chapter is contribute with information about the effects of these compounds on the biota as well as its environmental behavior and bacterial resistance in additional to the main techniques for samples preparation and quantitative and confirmatory methods for its determination in the environment.

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“…56,57 Trabalhos mais recentes têm usado o método QuEChERS e suas modificações para extração de antibióticos e clean-up em matrizes de origem animal. 14,88,[90][91][92][93] No método original, a acetonitrila é utilizada para extração dos analitos e precipitação das proteínas, com remoção da água e separação de fases por salting out com sulfato de magnésio e cloreto de sódio. Posteriormente o extrato é submetido à etapa de clean up por EFS-dispersiva usando PSA (amina primária e secundária) e analisado diretamente por cromatografia gasosa ou líquida com detectores de massa.…”

Section: Métodos Cromatográficos Confirmatórios E Multirresíduosunclassified

Resíduos de medicamentos veterinários em leite e ovos

Pacheco-Silva¹,

Souza²,

Caldas³

2014

Quím. Nova

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VETERINARY DRUG RESIDUES IN MILK AND EGGS. The use of veterinary drugs in food producing animals may result in the presence of residues in foods, including milk and eggs. Immunoassay or microbiological tests are used to screen for residues, but chromatographic methods are needed to confirm positive results. In most methods, the sample is extracted with acetonitrile, submitted to clean up or directly analyzed by LC-MS/MS. Results of the Brazilian governmental monitoring programs from 2006 to 2011 have shown that the antiparasitic ivermectin was the drug most frequently found in milk. Residues in eggs are only monitored by one of the programs, and few studies have reported the incidence of veterinary drugs in this matrix in Brazil.Keywords: veterinary drugs; milk; eggs. INTRODUÇÃOMedicamentos são usados na medicina veterinária no tratamento e prevenção de doenças ou como promotores de crescimento. 1,2 Estes compostos compreendem uma variedade de classes químicas com ações terapêuticas diversas, incluindo antibiótica/antimicrobiana, antiparasitária, inseticida, fungicida e sedativa. 3 Os antimicrobianos (b-lactâmicos, aminoglicosídeos e tetraciclinas) e os antiparasitários (avermectinas, piretróides e organofosforados) são os produtos mais comercializados no Paraná para tratamento do rebanho leiteiro. 4 O uso de medicamentos veterinários em animais produtores de alimentos pode deixar resíduos nos alimentos, como carne, leite e ovos, cujos níveis não devem ultrapassar o Limite Máximo de Resíduos (LMR). O LMR é a concentração máxima de resíduo em um alimento de origem animal resultante do uso de um medicamento veterinário (expresso em mg/kg ou µg/kg, em peso fresco) que é recomendado para ser legalmente permitido ou reconhecido como sendo aceitável no alimento. 5 Estes limites são estabelecidos para garantir o uso adequado destes produtos, limitar a exposição e proteger a saúde dos consumidores dos alimentos provenientes de animais tratados. 5 A presença de resíduos em um alimento acima do LMR estabelecido indica que o produto não foi utilizado segundo as boas práticas de uso de medicamentos veterinários (BPMV), ou o uso de um produto não autorizado. 6 O Brasil não estabelece LMR para medicamentos veterinários, adotando aqueles recomendados pelo Mercosul, Codex Alimentarius, União Européia ou Estados Unidos. 7 A exposição humana a resíduos de medicamentos veterinários presentes nos alimentos pode causar efeitos adversos, incluindo reações alérgicas em indivíduos hipersensíveis 8 e câncer. 9,10 Adicionalmente, a exposição a antimicrobianos/antibióticos pode provocar o desenvolvimento de microrganismos resistentes, que dificulta a ação terapêutica destes medicamentos em indivíduos que consumiram alimentos de animais tratados. 11,12 Resíduos de medicamentos veterinários no leite podem também causar problemas tecnológicos nos processos de fermentação dos laticínios. 13,14 No Brasil, há dois programas nacionais que monitoram a presença de resíduos de medicamentos veterinários em produtos de origem animal. O Plano Nacional...

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Multiresidue determination of veterinary drugs in aquaculture fish samples by ultra high performance liquid chromatography coupled to tandem mass spectrometry

Cited by 117 publications

References 36 publications

Simultaneous determination of flupyradifurone and its two metabolites in fruits, vegetables, and grains by a modified quick, easy, cheap, effective, rugged, and safe method using ultra high performance liquid chromatography with tandem mass spectrometry

Simultaneous determination of flupyradifurone and its two metabolites in fruits, vegetables, and grains by a modified quick, easy, cheap, effective, rugged, and safe method using ultra high performance liquid chromatography with tandem mass spectrometry

Veterinary Antibiotics in the Environment

Resíduos de medicamentos veterinários em leite e ovos

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