Veterinary Antibiotics in the Environment

Botelho, Rafael Guimarães; Monteiro, Sérgio Henrique; LuizTornisielo, Valdemar

doi:10.5772/60847

Cited by 10 publications

(14 citation statements)

References 142 publications

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“…Beta-lactams have been considered as less toxic, but they also affect the division of plastids in lower plants [14]. Also an inhibition of catalase activity in the adult brain of Danio rerio, a fish species used in ecotoxicity evaluation, was observed in case of exposures to high concentrations of amoxicillin (50-100 mg/L) [16].…”

Section: The Behavior Of Antibiotic Residues and Their Effects On Thementioning

confidence: 99%

“…Tetracyclines have phytotoxic effects that can cause chromosomal aberrations and inhibit plant growth, reducing the content of photosynthetic chlorophyll and carotenoid pigments in plants. Oxytetracycline is bioconcentrated in some aquatic plants that are destined for human consumption and which have been previously fertilized with pig manure [16]. Also, it has been shown that chlortetracycline and tetracycline could induce DNA breakage and changes in the enzymatic activities (superoxide dismutase and catalase) of Eisenia fetida (earthworms) [80].…”

Section: The Behavior Of Antibiotic Residues and Their Effects On Thementioning

confidence: 99%

“…Also, the concentrations of antibiotics which are found in agricultural soils could delay germination or reduce biomass, and consequently may negatively affect yield in farmland fertilized with contaminated manure [15]. Moreover, antibiotic residues can alter the human microbiome and cause health disturbances, such as allergic reactions, chronic toxic effects after prolonged exposure, and disruption of digestive system functions [1,3,16].…”

Section: Introductionmentioning

confidence: 99%

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Antibiotics in the environment: causes and consequences

Polianciuc

Gurzău²,

Kiss

et al. 2020

Medicine and Pharmacy Reports

148

123

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Antibiotics represent one of the main discoveries of the last century that changed the treatment of a large array of infections in a significant way. However, increased consumption has led to an exposure of bacterial communities and ecosystems to a large amount of antibiotic residues. This paper aims to provide a brief overview of the primary drivers associated with antibiotic occurrence in the environment. Furthermore, we attempted to summarize the behavior of antibiotic residues in the environment and the necessity of their detection and quantification. Also, we provide updated scientific and regulatory facts about environmental antibiotic discharge and environmental and human antibiotics risk assessment. We propose that environmental antibiotic contamination should be diminished beginning from regulating the causes of occurrence in the environment (such as antibiotic consumption) and ending with regulating antibiotic discharge and risk assessment. Some important intermediate steps are represented by the detection and quantification of the antibiotics and the characterization of their behavior in the environment, which could come to support future regulatory decisions.

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Section: The Behavior Of Antibiotic Residues and Their Effects On Thementioning

confidence: 99%

Section: The Behavior Of Antibiotic Residues and Their Effects On Thementioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Antibiotics in the environment: causes and consequences

Polianciuc

Gurzău²,

Kiss

et al. 2020

Medicine and Pharmacy Reports

148

123

View full text Add to dashboard Cite

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“…However, as much as 90% of antibiotic intake is excreted in feces and manure because antibiotics are poorly absorbed by the gut [9][10][11]. These substances are then released into the agricultural environment by the direct application of organic manure for soil fertilization [6].…”

Section: Introductionmentioning

confidence: 99%

Influence of Sulfonamide Contamination Derived from Veterinary Antibiotics on Plant Growth and Development

et al. 2020

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Veterinary antibiotics such as sulfonamides are widely used to increase feed efficiency and to protect against disease in livestock production. The sulfonamide antimicrobial mechanism involves the blocking of folate biosynthesis by inhibiting bacterial dihydropteroate synthase (DHPS) activity competitively. Interestingly, most treatment antibiotics can be released into the environment via manure and result in significant diffuse pollution in the environment. However, the physiological effects of sulfonamide during plant growth and development remain elusive because the plant response is dependent on folate biosynthesis and the concentration of antibiotics. Here, we present a chemical interaction docking model between Napa cabbage (Brassica campestris) DHPS and sulfamethoxazole and sulfamethazine, which are the most abundant sulfonamides detected in the environment. Furthermore, seedling growth inhibition was observed in lentil bean (Lens culinaris), rice (Oryza sativa), and Napa cabbage plants upon sulfonamide exposure. The results revealed that sulfonamide antibiotics target plant DHPS in a module similar to bacterial DHPS and affect early growth and the development of crop seedlings. Taking these results together, we suggest that sulfonamides act as pollutants in crop fields.

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“…Transformation of antibiotic residues could easily reach soil, surface and ground water via many routes such as sub-surface flow, drain flow or leaching [11,58]. The concentration of the transformed residues are affected by many factors including the chemical and physical properties of the antibiotic molecule, sorption behavior and persistence, exchange capacity of the soil matrix besides the various climate conditions [16].…”

Section: Risk and Impact Of Veterinary Antibiotics On Human Health Anmentioning

confidence: 99%

Necessary Usage of Antibiotics in Animals

Saad¹,

Ahmed²

2018

Antibiotic Use in Animals

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Animals could become sick at any time of their lives, just like all people exposed. Many of the antibiotics administered to animals are identical to or closely drugs used in human. All animal species in general and food-producing animals, in particular, are commonly exposed to antibiotics to treat and prevent infectious diseases or to promote growth. Antibiotics would not be necessary if animals were raised differently under good veterinary and husbandry practices that were less crowded and more sanitary. The proper and responsible use of antibiotics in veterinary medicine mandate an active cooperation between all the interested parties involved in livestock production cycles. All parties are invited to act together to ensure the ultimate goals of maintaining the efficacy and safety of veterinary antibiotics and complying the established maximum residue limits (MRLs) of the products of animal origin intended for human consumption. Antibiotics as hazardous substances should be applied and directed during the different steps starting from prescription until ensuring the withdrawal period under the supervision of professionals and veterinarians. Practices indicated that there is a need to improve sensitivity testing services and facilities before prescribing the proper antibiotic.

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Veterinary Antibiotics in the Environment

Cited by 10 publications

References 142 publications

Antibiotics in the environment: causes and consequences

Antibiotics in the environment: causes and consequences

Influence of Sulfonamide Contamination Derived from Veterinary Antibiotics on Plant Growth and Development

Necessary Usage of Antibiotics in Animals

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