Multiple primary gynecologic neoplasms

Rose, Peter G.; Herterick, Edward E.; Boutselis, John G.; Moeshberger, Melvin; Sachs, Larry

doi:10.1016/s0002-9378(87)80148-5

Cited by 42 publications

(36 citation statements)

References 14 publications

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“…almost 50% of neoplasms occurring together with gastrointestinal tumors are gynecological, among which 77.5% are cervical cancers [18]. Subsequent gynecological cancer occurs in 1.6% of patients with cervical cancer, 4.3% of patients with vulvar cancer and 9.6% with vaginal cancer [19]. There is no unanimity in the literature concerning the coexistence of uterine cervix and breast cancers.…”

Section: Discussionmentioning

confidence: 99%

“…The risk of secondary neoplasms after radiotherapy is higher for tobacco-related cancers, which in the case of radiation due to cervical carcinoma refers to the increased risk of bladder cancer developing [12]. It is generally estimated that about 8% of multiple secondary carcinomas are related to former radiotherapy and about 5% of multiple gynecological cancer cases [12,19]. The risk of developing a subsequent cancer after radiation oscillates from 1.03 after thyroid neoplasm treatment to 1.78 due to cervical cancer treatment [12].…”

Section: Discussionmentioning

confidence: 99%

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Multiple Neoplasms Among Cervical Cancer Patients in the Material of the Lower Silesian Cancer Registry

Izmajłowicz¹,

Kornafel²,

Błaszczyk³

2014

Adv Clin Exp Med

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Background. according to the definition by the International agency for Research on cancer (IaRc), primary multiple neoplasms are two or more neoplasms of different histopathological build in one organ, or two or more tumors occurring in one patient, regardless of the time of their occurrence (synchronic -up to 6 months, metachronous -after 6 months), coming from an organ or a tissue and not being an infiltration from another neoplasm, a relapse or a metastasis. Objectives. It was the aim of the study to analyze the frequency of the occurrence of multiple neoplasms among patients suffering from uterine cervix cancer, with a special interest in coexistent neoplasms, the time of their occurrence and total 5-year survivals. Material and Methods. The data from the Lower Silesian cancer Registry concerning the years 1984-2009 formed the material of the present study. Results. 5.3% of all cervix neoplasms occurred as multiple cancers. cervix neoplasms were 13.4% of multiple neoplasms. On average, cervical cancer occurred as a subsequent cancer in 6 patients yearly (60.7% of the occurrences of cervical cancer were in the period of 5 years following treatment for the first neoplasm). 5-year survival in patients suffering from primarily multiple cervix neoplasms constituted 57% and was convergent with the results for all patients suffering from cervical cancer. cervical cancer as the first neoplasm occurred in 287 patients, on average in 11 patients annually. In the period of the first 5 years after the treatment of cervical cancer, there were 42.8% occurrences of other cancers. cervical neoplasms most frequently coexisted with cancers of the breast, lung and large intestine. Conclusions. The frequency of the occurrence of multiple neoplasm among cervical cancer patients is increasing. Most frequently they coexist with other tobacco-related neoplasms, those related to HPV infections and with secondary post-radiation neoplasms. These facts should be taken into consideration during post-treatment observation and when directing diagnostic and prophylactic tests. Synchronic neoplasms require detailed diagnostics and planning of treatment by a team of specialists. The occurrence of primary multiple cervical neoplasms does not worsen the prognosis as compared to patients suffering exclusively from cervical cancer (Adv Clin Exp Med 2014, 23, 3, 433-440).

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Multiple Neoplasms Among Cervical Cancer Patients in the Material of the Lower Silesian Cancer Registry

Izmajłowicz¹,

Kornafel²,

Błaszczyk³

2014

Adv Clin Exp Med

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“…3,7Y9 The reported 10,11 prevalence rate of occurrence of endometrial carcinoma in patients with ovarian carcinoma varies between 1.6% and 67.0%. Conversely, the prevalence rate 10,12 of occurrence of ovarian carcinoma in patients with endometrial carcinoma is relatively low and ranges from 0.7% to approximately 10%.…”

Section: Discussionmentioning

confidence: 99%

Synchronous Primary Carcinoma in 5 Different Organs of a Female Genital Tract

Atasever

Yılmaz²,

Dilek

et al. 2009

International Journal of Gynecological Cancer

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The occurrence of double simultaneous primary cancers of the female reproductive tract is a common event. However, the occurrence of synchronous primary quadruple gynecologic malignancies is extremely rare. In this report, the clinical and pathological findings of a 35-year-old female patient with synchronous primary gynecologic cancers regarding papillary serous carcinoma of the left ovary, microinvasive carcinoma in situ of the left and right uterine tubes, endometrial intraepithelial carcinoma of the endometrium, and endocervical carcinoma in situ of the uterine cervix were presented. To our knowledge, the patient presented is the first case in aspect of accompanying ovarian papillary serous carcinoma to bilateral tubal microinvasive carcinoma in situ, endometrial intraepithelial carcinoma, and endocervical carcinoma in situ of the uterine cervix.

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“…The risk of second primary anogenital cancer, namely of the vagina, vulva and anus, following cervical carcinoma has been found to be slightly elevated [1] . Rabkin et al [2] published an analysis of multiple primary cancer patients from the Connecticut tumor registry and the Surveillance, Epidemiology and End Result program of the National Cancer Institute.…”

Section: Discussionmentioning

confidence: 99%

“…Detection of multiple primary cancers in a single patient is not frequently encountered [1,2] , and the carcinogenesis of multiple primary cancers in the urogenital area is still unknown. Compelling epidemiological and molecular evidence now supports the connection between specific human papillomavirus (HPV) infection mous cell carcinoma.…”

Section: Introductionmentioning

confidence: 99%

Human Papillomavirus DNA in Triple Neoplasms of the Cervix, Perianus and Ureter in One Woman

Huang¹,

Pan²,

Lin³

et al. 2006

Gynecol Obstet Invest

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Background: Multiple malignancies of the urogenital tract have been reported. We investigated the etiological role of human papillomavirus (HPV) in the pathogenesis of urogenital cancers. Case: We present a case of cervical squamous carcinoma in a 64-year-old woman who subsequently developed Bowen’s disease in the perianal skin and transitional cell carcinoma of the ureter. HPV DNA was detected in these tumor specimens using polymerase chain reaction. Conclusion: The results strongly suggest that HPV may play a major role in the carcinogenesis of urogenital and perianal tumors.

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Multiple primary gynecologic neoplasms

Cited by 42 publications

References 14 publications

Multiple Neoplasms Among Cervical Cancer Patients in the Material of the Lower Silesian Cancer Registry

Multiple Neoplasms Among Cervical Cancer Patients in the Material of the Lower Silesian Cancer Registry

Synchronous Primary Carcinoma in 5 Different Organs of a Female Genital Tract

Human Papillomavirus DNA in Triple Neoplasms of the Cervix, Perianus and Ureter in One Woman

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