Multiple Neoplasms Among Cervical Cancer Patients in the Material of the Lower Silesian Cancer Registry

Abstract

Background. according to the definition by the International agency for Research on cancer (IaRc), primary multiple neoplasms are two or more neoplasms of different histopathological build in one organ, or two or more tumors occurring in one patient, regardless of the time of their occurrence (synchronic -up to 6 months, metachronous -after 6 months), coming from an organ or a tissue and not being an infiltration from another neoplasm, a relapse or a metastasis. Objectives. It was the aim of the study to analyze the frequency of the occurrence of multiple neoplasms among patients suffering from uterine cervix cancer, with a special interest in coexistent neoplasms, the time of their occurrence and total 5-year survivals. Material and Methods. The data from the Lower Silesian cancer Registry concerning the years 1984-2009 formed the material of the present study. Results. 5.3% of all cervix neoplasms occurred as multiple cancers. cervix neoplasms were 13.4% of multiple neoplasms. On average, cervical cancer occurred as a subsequent cancer in 6 patients yearly (60.7% of the occurrences of cervical cancer were in the period of 5 years following treatment for the first neoplasm). 5-year survival in patients suffering from primarily multiple cervix neoplasms constituted 57% and was convergent with the results for all patients suffering from cervical cancer. cervical cancer as the first neoplasm occurred in 287 patients, on average in 11 patients annually. In the period of the first 5 years after the treatment of cervical cancer, there were 42.8% occurrences of other cancers. cervical neoplasms most frequently coexisted with cancers of the breast, lung and large intestine. Conclusions. The frequency of the occurrence of multiple neoplasm among cervical cancer patients is increasing. Most frequently they coexist with other tobacco-related neoplasms, those related to HPV infections and with secondary post-radiation neoplasms. These facts should be taken into consideration during post-treatment observation and when directing diagnostic and prophylactic tests. Synchronic neoplasms require detailed diagnostics and planning of treatment by a team of specialists. The occurrence of primary multiple cervical neoplasms does not worsen the prognosis as compared to patients suffering exclusively from cervical cancer (Adv Clin Exp Med 2014, 23, 3, 433-440).

Clinical characteristics and prognostic analysis of multiple primary malignant neoplasms in female patients with breast cancer or genitalia malignancies

“…Previous studies have shown an increased risk of cervical cancer and lung cancer with mutations in the LKB1 gene ( Sanchez-Cespedes, 2007 ; Wingo et al, 2009 ). In addition, some studies have confirmed that breast cancer or genitalia malignancies were closely related to lung cancer and colorectal cancer ( Izmajłowicz, Kornafel & Błaszczyk, 2014 ; Luciani et al, 2009 ; Zhai et al, 2018 ). A prospective cohort study based on a female breast cancer population showed that the SIR of secondary primary colorectal cancer among breast cancer survivors was 1.59 ( Lu et al, 2016 ) BRCA mutations heighten the risk of developing breast cancer.…”

The clinicopathological features of second primary cancer in patients with prior breast cancer

“…[23,24] In this study, the mean interval time from the first cancer diagnosis to the second cancer diagnosis was 83.89 months. Three patients had positive family history.…”

Malignant fibrous histiocytoma of the axilla with breast cancer: A case report

“…The main mechanisms of MPMNs include genetic factors, environmental factors (smoking, alcoholism, obesity, etc ) and iatrogenic factors (radiotherapy, chemotherapy, etc ). It has been found that there is no difference in prognosis between patients with MPMNs and those with only one type of cancer[ 3 , 4 ]. The reasons may be related to the gradual increase of complete resection rate, standardized postoperative management and prolonged survival of patients.…”