Synchronous Primary Carcinoma in 5 Different Organs of a Female Genital Tract

Atasever, Melahat; Yılmaz, Bülent; Dilek, Gülay; Akçay, Eda Yılmaz; Kelekçi, Sefa

doi:10.1111/igc.0b013e3181a39b95

Cited by 19 publications

(17 citation statements)

References 22 publications

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“…The rest are of triple synchronous malignancies involving uterus, cervix and ovaries in varying combinations. 1,[6][7][8] . A comparative list of the reported cases has been listed in Table 1.…”

Section: Discussionmentioning

confidence: 99%

“…Numerous attempts have been made to explain the pathogenesis of multiple synchronous primary malignancies. Tissues that share a common embryonic origin show an increased propensity to develop concurrent tumors when they are repeatedly and simultaneously exposed to carcinogens, hormones and other triggers 5,6 . The concept of field cancerization, as explained by Slaughter et al, in 1953 for tumors of the head and neck region has also been proposed as a plausible explanation to multiple primaries of the female genital tract.…”

Section: E F G Hmentioning

confidence: 99%

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Triple Synchronous Primary Malignancies of Ovary, Endometrium and Cervix – A Rare Case Report

Shah¹

2018

jmscr

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Section: Discussionmentioning

confidence: 99%

Section: E F G Hmentioning

confidence: 99%

Triple Synchronous Primary Malignancies of Ovary, Endometrium and Cervix – A Rare Case Report

Shah¹

2018

jmscr

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“…Considering that synchronous cancers are often detected at early stage, it is possible to treat them radically [15][16][17][18]. The role of diagnostic and therapeutic interdisciplinary teams is paramount in this case.…”

Section: Discussionmentioning

confidence: 99%

Strategy and early results of treatment of advanced cervical cancer patients with synchronous cancers observed in PET-CT imaging

et al. 2017

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Objectives: The aim of this study was to present strategy and early results of treatment of advanced cervical cancer patients with synchronous cancers observed in PET-CT imaging, treated at the Greater Poland Cancer Center. Material and methods:The study included a group of 200 patients with diagnosed stage IIB-IIIB cervical cancer who received PET-CT for the purpose of radiotherapy treatment planning.Results: Among our study group, four patients (2%) were found to have a synchronous cancer. Two of the cases were diagnosed as breast cancer. However, cancers diagnosed in the other two patients were head and neck malignancies -hypopharyngeal and laryngeal cancer. The choice of an optimal therapeutic approach requires taking into account characteristics of particular malignancies, their stage and histopathology. The whole therapy included radiotherapy of cervical cancer with various combinations of systemic treatment, radiotherapy or surgery of synchronous cancer. According to treatment results, patients diagnosed with breast cancer and hypopharyngeal cancer achieved complete remission of both primary and secondary tumour. Patient diagnosed with laryngeal malignancy, despite achieving complete remission of cervical cancer, finished radiotherapy of the synchronous cancer at a palliative dose. Conclusions:The growing availability of PET-CT and other imaging methods in cancer diagnosis will increase the number of diagnosed synchronous cancers. Second primary cancers are often detected at an early stage, where radical treatment can be performed for both primary and secondary tumour. However, treatment of such complicated clinical cases as synchronous cancers should be carried out by multidisciplinary teams.

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“…The coexistence of synchronous multiple primary malig- nancies is very interesting. A case of synchronous primary carcinomas in five different organs of a female genital tract has been reported (7). Even though the treatment is similar as if they were single primary tumors, the prognosis of patients with synchronous primary cancers are generally better than the patients with metastatic disease of a single tumor (2,3).…”

Section: Discussionmentioning

confidence: 99%

Synchronous Endometrial and Ovarian Cancer With Sigmoid Colon Metastasis One Year After Primary Surgery: A Case Report

Güzin¹,

Balcı²,

Sandal³

et al. 2015

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IntroductionThe presence of synchronous primary malignancies in the female genital tract is relatively rare. Primary tumors in two organs within a single person is called synchronous primary malignancies. The two types of synchronous cancers commonly reported have been ovarian cancer and endometrial cancer (1,2). Synchronous primary tumor of the endometrium and ovary occur in up to 10% of all ovarian cancer cases and 5% of all endometrial cancer cases (3). Patients with simultaneous uterine and ovarian cancers do generally show a better prognosis than those with metastatic disease. (2,4-6). We describe herein, a patient whose disease was not consistent with this data, she had ovarian cancer (stage 1A) and endometrial cancer (stage 1A) which metastasized to sigmoid colon one year after surgery. Case PresentationA 53-year-old postmenopausal women, with a history of 5 pregnancies, 2 deliveries, 1 dilatation and curettage and 2 missed abortus, admitted to our clinic with the complaints of abdominal pain, abdominal distension and postmenopausal bleeding. Her family and previous disease histories were unremarkable. Her physical examination and transvaginal ultrasound scan revealed free fluid in the abdominal cavity and a cystic mass containing papillary projections with the dimensions of 6.5 × 5 × 4 cm on the right ovary. Tumor marker (carbohydrate antigen) (CA) 125 was elevated, 223 IU. The dilatation and curettage was performed and the histopathological diagnosis of endometrial curettage was endometrioid adenocarcinoma. Computed tomography revealed no metastasis. Under the diagnosis of endometrial cancer and probably ovarian cancer; malignant ascites sampling, radical hysterectomy, bilateral salpingo-oophorectomy, pelvic and paraaortic lymphadenectomy, omentectomy, appendectomy and cytologic sampling of the undersurface of the diaphragm were carried out (tumor free). Histopathological diagnosis of endometrial cancer was grade 2 adenocarcinoma with squamous differentiation (stage 1A) with less than Abstract Introduction: We describe a patient who had ovarian and endometrial cancer which metastasized to sigmoid colon one year after surgery. Case Presentation: A 53-year-old woman was admitted with the complaints of abdominal pain, abdominal distension and postmenopausal bleeding. Her transvaginal ultrasound scan revealed a cystic mass containing papillary projections with the dimensions of 6.5 × 5 × 4 cm on the right ovary. Level of (carbohydrate antigen) (CA) 125 was 223 IU. Dilation and curettage revealed endometrioid adenocarcinoma. Debulking surgerywas carried out. Histopathological diagnosis was grade 2 adenocarcinoma with squamous differentiation for endometrial cancer and grade 2 endometrioid adenocarcinoma with squamous and mucinous differentiation for ovarian cancer. The stage was 1A for endometrial cancer and 1A for ovarian cancer. 12 months after the operation CA 125 level was 112 IU. Positron emission tomography (PET) scan showed a small lesion (1.5×1.5 cm) in the pelvic cavity with increased fluorodeoxyglu...

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Synchronous Primary Carcinoma in 5 Different Organs of a Female Genital Tract

Cited by 19 publications

References 22 publications

Triple Synchronous Primary Malignancies of Ovary, Endometrium and Cervix – A Rare Case Report

Triple Synchronous Primary Malignancies of Ovary, Endometrium and Cervix – A Rare Case Report

Strategy and early results of treatment of advanced cervical cancer patients with synchronous cancers observed in PET-CT imaging

Synchronous Endometrial and Ovarian Cancer With Sigmoid Colon Metastasis One Year After Primary Surgery: A Case Report

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