Low pre-treatment hemoglobin level may reflect poor prognostic factors such as positive cytology and cervical involvement in patients with endometrial cancer that is associated with thrombocytosis.

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The occurrence of double simultaneous primary cancers of the female reproductive tract is a common event. However, the occurrence of synchronous primary quadruple gynecologic malignancies is extremely rare. In this report, the clinical and pathological findings of a 35-year-old female patient with synchronous primary gynecologic cancers regarding papillary serous carcinoma of the left ovary, microinvasive carcinoma in situ of the left and right uterine tubes, endometrial intraepithelial carcinoma of the endometrium, and endocervical carcinoma in situ of the uterine cervix were presented. To our knowledge, the patient presented is the first case in aspect of accompanying ovarian papillary serous carcinoma to bilateral tubal microinvasive carcinoma in situ, endometrial intraepithelial carcinoma, and endocervical carcinoma in situ of the uterine cervix.

Glomus tumors are benign neoplasms that arise from neuromyoarterial glomus bodies. They represent around 1–5% of all soft-tissue tumors. High temperature, sensitivity, and pain and localized tenderness are the classical triad of symptoms. Most glomus tumors represent in the subungual area of digits. Extradigital glomus tumors are a very rare entity. There are rare cases of these tumors reported to be in shoulder, elbow, knee, wrist, even stomach, colon, and larynx. We are reporting a case of a glomus tumor on thigh and discuss the histological and immunohistochemical features.

Background and Objectives: The purpose of this study was to evaluate the mammographic, sonographic and MRI findings of metaplastic breast carcinoma. Methods: In this retrospective review study, we analyzed the medical files of 9600 patients who were treated for invasive breast cancers. Clinical information, histopathologic and radiologic findings of 65 patients were included in this study. All existing radiologic images and medical reports were reviewed retrospectively. Thirty-three patients had MG, 58 patients had US and 7 patients had MRI imaging results. Results: Mammographically, the most frequent presentations of MPBC were round shape, microlobulated margin and high density masses. Calcifications with or without masses were not a frequent finding. The most common sonographic findings were round shape, partially indistinct angular margin, hypoechoic and heterogeneous echo patterns and no posterior feature masses. All lesions were presented as masses rather than non-mass enhancements on magnetic resonance imaging. Features of masses had more malignant feature on MRI than other modalities in all 7 patients. Conclusion: Metaplastic breast carcinoma is one of the rarest poorly differentiated invasive breast carcinomas. Interestingly, these aggressive tumors demonstrate benign or moderately malign features on imaging methods. This appearance of MPBC can cause it to be misdiagnosed as a benign breast lesion especially in young women. MPBC should be kept in mind in the differential diagnosis of large palpable breast masses. Therefore, follow-up at short intervals and/or multimodality imaging studies which include breast MRI are important for the diagnosis of MPBC.

Background:CSE1L (chromosome segregation 1-like) is the human homologue to the yeast gene CSE1, and is related to invasion and metastasis in cancer progression. The aim of this study was to investigate the potential role of CSE1L expression in distant metastasis of breast cancer. Patients and Methods: A total of 71 breast cancer patients were included in this study. Clinical characteristics and CSE1L status were evaluated. Immunohistochemistry was performed on formalin-fixed, paraffin-embedded archival breast tumor tissue. The results of CSE1L staining were analyzed according to the percentage of immunoreactive cells. Results: 34 patients had distant metastasis and 37 did not. The mean age of the patients was 50.5 ± 12.1 years. Age, tumor size, and hormone receptor status were similar in patients with distant metastasis and in those without. A statistically significant relationship was found between nuclear CSE1L expression and distant metastasis of breast cancer. Lymph node metastasis and nuclear grade were other factors affecting distant metastasis. Conclusion: There is a relationship between nuclear CSE1L overexpression and distant metastasis in breast cancer. CSE1L status may therefore become a valuable prognostic tool in the future.

ÖZETTiroid bezinde papiller tiroid karsinomu ve medüller tiroid karsinomunun birlikte oluşumu nadir bir durumdur. Papiller tiroid karsinomu folliküler hücrelerden kaynaklanırken medüller tiroid karsinomu parafolliküler hücrelerden kaynaklanır. Bu olgu sunumunda tiroiddeki nodülden ince iğne aspirasyon biopsisi sonucu folliküler neoplazi olması nedeniyle total tiroidektomi yapılan ve operasyon sonrası patolojik incelemesi papiller karsinom ve aynı lobda medüller karsinom olarak raporlanan 65 yaşında erkek hasta sunuldu. Anahtar Kelimeler: Papiller karsinom, medüller karsinom, tiroid, eş zamanlı ABSTRACT Papillary thyroid carcinoma and medullary thyroid carcinoma in the thyroid gland is a rare condition. Papillary thyroid carcinoma originates from follicular cells, medullary thyroid carcinoma originates from parafollicular cells. We report the case of a 65 years old man who developed a thyroid follicular neoplasia. The patient was operated to our department with total thyroidectomy. In the pathological examination of the specimen showed papillary carcinoma and medullary carcinoma in the right lobe. Key words: Papillary thyroid carcinoma, medullary thyroid carcinoma, thyroid, concurrent GirişTüm yaş gruplarında papiller tiroid kanseri insidansı artış göstermekte olup, en fazla artış görülme oranı üreme çağındaki kadınlardadır (1,2).Tiroid foliküler hücrelerinden köken alan bu karsinomda radyasyon en iyi bilinen risk faktörü olup, çocukluk çağında radyasyona maruz kalma ile papiller tiroid kanseri arasında kesin bir ilişki bulunduğu gösterilmiştir.Olguların % 50'sinde boyun lenflerine yayılım görülmektedir. Diğer malignitelerin tersine boyun bölgesine lenfatik yayılım sağkalımı etkilememektedir (3). Uzak metastaz olguların % 20'sinde gelişebilir, en sık metastaz akciğer, kemik, beyin ve karaciğere olur (4). Rekürrens % 10-15 arasında olup, sıklıkla tümör çapı, tiroid kapsülünü aşma, lenf metastazı ve agresif histolojik tiple ilişkilidir. (5,6,7). Mortalite papiller tiroid kanserli hastalarda 5 yıllık takipte % 2, 10 yıllıkta % 4, 20 yıllık takipte ise % 5'tir (8). İnce iğne aspirasyon biopsisi tanıda altın standart olup, deneyimli ellerde duyarlılık % 98, pozitif prediktif değeri ise % 99 oranlarındadır(3).Medullar tiroid kanser (MTK) bir nöroendokrin tümör olup, tiroidin parafoliküler (C hücreleri) hücrelerinden köken alır . Tiroid kanserlerinin yaklaşık % 2-5'ini oluşturur (8). Kadın erkek oranı 1.5/1 olup, en sık görülme 50-60 yaşlarındadır (4). Prognozu ise papiller kansere göre daha kötüdür.Olgu Sunumu 65 yaşında erkek hasta, genel cerrahi polikliniğine boyunda şişlik şikayeti ile başvurdu. Hastanın radyasyona maruziyet öyküsü ve eşlik eden yandaş hastalığı yoktu. Yapılan tetkiklerinde tiroid fonksiyon testleri normaldi, tiroid bezinin ultrasonografik görüntülemesinde tiroid sol lob orta arka kesimde 15x9mm boyutlarında heterojen ekoda semisolid nodül ve sağ lob üst ön kesimde 20x10mm subkapsüller ortasında kistik alan ve punktat kalsifikasyonlar olan, dopplerde periferik tip kanlanma gösteren heterojen nodüler...

Fine needle aspiration biopsy is commonly used for pre operative evaluations of salivary gland masses. We would like to focus on this diagnostic tool for the salivary gland lesions by reviewing Ankara Oncology Hospital's case lists. Cytological and postoperatively histological reassessment is done for 115 cases. Fine needle aspiration biopsy's sensitivity was 80.8 %, specificity 95.1 %, positive predictive value was 84 % and negative predictive value was 93.9 %. False positive range was 4.9 % and false negative range was 19.2 %. Salivary gland masses can be assessed by cytology preoperatively.