Multiple labelled nanoparticles for bio detection

Docherty, F. T.; Clark, Maureen; McNay, Graeme; Graham, Duncan; Smith, W. Ewen

doi:10.1039/b306684c

Cited by 34 publications

(25 citation statements)

References 18 publications

(21 reference statements)

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“…This method was used for the identification of Saccharomyces cerevisiae, E. coli F-amp, and Bacillus subtilis. To find the potential applicability of confocal SERS for sensitive biological detection in a microfluidic channel, Docherty et al [100] have demonstrated simultaneous SERS detection of three dye-labeled oligonucleotides with E. coli sequences in a microfluidic channel. The narrow SERS signals, compared with broad fluorescence emission bands, enable the simultaneous detection of multiple analytes.…”

Section: Biological Analysis and Biomedical Diagnosticsmentioning

confidence: 99%

Recent advances in surface‐enhanced Raman scattering detection technology for microfluidic chips

2008

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Microfluidic chip devices and their application to sensitive chemical and biological analyses have attracted significant attention over the past decade. The miniaturization of reaction systems offers practical advantages over conventional benchtop systems. In this case, however, a highly sensitive on-chip detection method is important for the monitoring of chemical reactions as well as for the detection of analytes inside the channel because the detection volume in a micrometer-size channel is extremely small. Recently, a surface-enhanced Raman scattering (SERS) technique is being regarded as a potential candidate for the highly sensitive detection of analytes in a microfluidic chip. This review provides a general survey and an in-depth look at recent developments in SERS techniques for the biological/environmental analysis of minute analytes in a microfluidic chip.

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Section: Biological Analysis and Biomedical Diagnosticsmentioning

confidence: 99%

Recent advances in surface‐enhanced Raman scattering detection technology for microfluidic chips

2008

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“…Surface-enhanced Raman scattering (SERS), a technique with high spectral specificity, multiplex capabilities, and photostability [1][2][3], has been widely applied to chemical analysis, biological detection and medical diagnosis [4][5][6].…”

Section: Introductionmentioning

confidence: 99%

Silver–gold core-shell nanoparticles containing methylene blue as SERS labels for probing and imaging of live cells

Guo

Jia

et al. 2012

Microchim Acta

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We report on silver-gold core-shell nanostructures that contain Methylene Blue (MB) at the gold-silver interface. They can be used as reporter molecules in surfaceenhanced Raman scattering (SERS) labels. The labels are stable and have strong SERS activity. TEM imaging revealed that these nanoparticles display bright and dark stripe structures. In addition, these labels can act as probes that can be detected and imaged through the specific Raman signatures of the reporters. We show that such SERS probes can identify cellular structures due to enhanced Raman spectra of intrinsic cellular molecules measured in the local optical fields of the core-shell nanostructures. They also provide structural information on the cellular environment as demonstrated for these nanoparticles as new SERS-active and biocompatible substrates for imaging of live cells.

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“…SERRS can be used, for example, for labeling both fluorophores and non-fluorophores. To test the sensitivity of the assay, the detection of 3,5-dimethoxy-4-(6 0 -azobenzotriazolyl)-phenylamine anchored on an Ag nanoparticle surface was studied, indicating a detection limit of about 10 À10 M [63]. Carrageenan biopolymers have also been used as a template and as reduction agent for the synthesis of Ag metallic nanoparticles.…”

Section: Carrageenansmentioning

confidence: 99%