Recent advances in surface‐enhanced Raman scattering detection technology for microfluidic chips

Chen, Lingxin; Choo, Jaebum

doi:10.1002/elps.200700554

Cited by 208 publications

(171 citation statements)

References 103 publications

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“…However, in the case of SERS, this can hurt the detection limit as compared to conventional techniques because of the reduced sample volume and the diffusion-limited transport of analyte molecules within the channel. 10,11 To overcome these barriers, a number of reports have demonstrated improved performance of SERS in microsystems by leveraging the principles of optofluidics, which is defined by the synergistic integration of photonics and microfluidics. [12][13][14][15] In one example of an optofluidic SERS technique, photonic crystal waveguides maximize the interaction of the excitation laser light with nanoparticle-analyte conjugates.…”

Section: Introductionmentioning

confidence: 99%

A nanoporous optofluidic microsystem for highly sensitive and repeatable surface enhanced Raman spectroscopy detection

Yazdi

White

2012

Biomicrofluidics

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We report the demonstration of an optofluidic surface enhanced Raman spectroscopy (SERS) device that leverages a nanoporous microfluidic matrix to improve the SERS detection performance by more than two orders of magnitude as compared to a typical open microfluidic channel. Although it is a growing trend to integrate optical biosensors into microfluidic channels, this basic combination has been detrimental to the sensing performance when applied to SERS. Recently, however, synergistic combinations between microfluidic functions and photonics (i.e., optofluidics) have been implemented that improve the detection performance of SERS. Conceptually, the simplest optofluidic SERS techniques reported to date utilize a single nanofluidic channel to trap nanoparticle-analyte conjugates as a method of preconcentration before detection. In this work, we leverage this paradigm while improving upon the simplicity by forming a 3D nanofluidic network with packed nanoporous silica microspheres in a microfluidic channel; this creates a concentration matrix that traps silver nanoclusters and adsorbed analytes into the SERS detection volume. With this approach, we are able to achieve a detection limit of 400 attomoles of Rhodamine 6G after only 2 min of sample loading with high chip-to-chip repeatability. Due to the high number of fluidic paths in the nanoporous channel, this approach is less prone to clogging than single nanofluidic inlets, and the loading time is decreased compared to previous reports. In addition, fabrication of this microsystem is quite simple, as nanoscale fabrication is not necessary. Finally, integrated multimode fiber optic cables eliminate the need for optical alignment, and thus the device is relevant for portable and automated applications in the field, including point-of-sample and point-of-care detection. To illustrate a relevant field-based application, we demonstrate the detection of 12 ppb of the organophosphate malathion in water using the nanofluidic SERS microsystem.

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Section: Introductionmentioning

confidence: 99%

A nanoporous optofluidic microsystem for highly sensitive and repeatable surface enhanced Raman spectroscopy detection

Yazdi

White

2012

Biomicrofluidics

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“…Since the discovery of the SERS effect in the 1970s [16][17][18], SERS has been applied to a wide variety of biomedical and environmental analytical applications at the level of molecules, pathogens, cells, and even whole living animals [19][20][21][22]. The enhancement associated with SERSup to 10 14 times [23]-is widely attributed to two primary mechanisms: the short-range chemical effect and the longrange classical electromagnetic effect.…”

Section: Introductionmentioning

confidence: 99%

Rapid detection of melamine with 4-mercaptopyridine-modified gold nanoparticles by surface-enhanced Raman scattering

et al. 2011

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A surface-enhanced Raman scattering (SERS) strategy based on 4-mercaptopyridine (MPY)-modified gold nanoparticles (AuNPs) was developed for the rapid and sensitive detection of melamine in milk powder. The SERS measurement of melamine strongly relied on the "hotspot" effect, in which AuNPs immediately aggregated upon the addition of melamine, leading to significantly enhanced Raman intensity of the reporter molecule MPY and a color change for the solution from red to blue-gray. The limit of detection based on a signal to noise of 3 (S/N=3) was found to be as low as 0.1 ppb of melamine, with an excellent linearity of 0.5-100 ppb, demonstrating a higher sensitivity and a wider quantitation range than direct SERS sensing methods based on enhanced substrate. An impressive specificity for melamine detection over various common metal ions and excipients in dairy products, even at concentrations of 100-fold higher than melamine, was achieved. Good recoveries of 88.5% and 111.7% were obtained from milk samples spiked to 20 and 100 ppb levels, respectively. The proposed method is potentially applicable for the rapid in situ determination of melamine in complex matrices.

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“…The use of microfluidic based biosensors can eliminate many of these steps and thus reduce the possibility that human error can affect the measurements. This can potentially be translated into improved sensitivity, precision, ease of use, rapid results, and minimal amount of sample needed [178].…”

Section: Sers Combined With Microfluidicsmentioning

confidence: 99%

“…Several groups and multiple reviews have incorporated microfluidic technology with SERS-based assays to create sensitive sensors for potential POC applications [107,[178][179][180].…”

Section: Sers Combined With Microfluidicsmentioning

confidence: 99%

Surface enhanced Raman spectroscopy (SERS) for in vitro diagnostic testing at the point of care

et al. 2017

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Point-of-care (POC) device development is a growing field that aims to develop low-cost, rapid, sensitive in-vitro diagnostic testing platforms that are portable, selfcontained, and can be used anywhere -from modern clinics to remote and low resource areas. In this review, surface enhanced Raman spectroscopy (SERS) is discussed as a solution to facilitating the translation of bioanalytical sensing to the POC. The potential for SERS to meet the widely accepted "ASSURED" (Affordable, Sensitive, Specific, Userfriendly, Rapid, Equipment-free, and Deliverable) criterion provided by the World Health Organization is discussed based on recent advances in SERS in vitro assay development. As SERS provides attractive characteristics for multiplexed sensing at low concentration limits with a high degree of specificity, it holds great promise for enhancing current efforts in rapid diagnostic testing. In outlining the progression of SERS techniques over the past years combined with recent developments in smart nanomaterials, high-throughput microfluidics, and low-cost paper diagnostics, an extensive number of new possibilities show potential for translating SERS biosensors to the POC.

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Recent advances in surface‐enhanced Raman scattering detection technology for microfluidic chips

Cited by 208 publications

References 103 publications

A nanoporous optofluidic microsystem for highly sensitive and repeatable surface enhanced Raman spectroscopy detection

A nanoporous optofluidic microsystem for highly sensitive and repeatable surface enhanced Raman spectroscopy detection

Rapid detection of melamine with 4-mercaptopyridine-modified gold nanoparticles by surface-enhanced Raman scattering

Surface enhanced Raman spectroscopy (SERS) for in vitro diagnostic testing at the point of care

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