Multiple joint osteoarthritis in the osteoarthritis initiative

Eaton, Cyd K.; Roberts, Matthew M.; Driban, Jeffrey B.; Barbe, MF; Harkey, Matthew S.; Lo, Greninger; McAlindon, T.E.

doi:10.1016/j.joca.2019.02.146

Cited by 3 publications

(1 citation statement)

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“…OA occurs when the protective cartilage wears down during aging or after injuries [2]. Theoretically OA can cause irreversible damages to all joints, while the most commonly affected sites are knees, hips, hands and spine [2,3]. At present, the treatment of OA mainly focus on the relief of symptoms, such as the use of Acetaminophen to reduce moderate or mild pain, while current available medications may not work in severe cases [4,5].…”

Section: Introductionmentioning

confidence: 99%

Circular RNA circZNF652 is overexpressed in osteoarthritis and positively regulates LPS-induced apoptosis of chondrocytes by upregulating PTEN

Yuan

Zhang

Cai

et al. 2020

Preprint

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Background Circular RNA circZNF652 promotes LPS-induced inflammation, which contributes to the development of osteoarthritis (OA), indicating the potential involvement of CRNDE in OA. This study was carried to explore the involvement of circZNF652 in OA. Methods RT-qPCR was performed to analyze the expression of circZNF652 and PTEN mRNA in synovial fluid samples from 60 OA patients and 60 healthy controls. Correlations between circZNF652 and PTEN mRNA were analyzed by Pearson’s correlation coefficient. Overexpression and siRNA silencing of circZNF652 were achieved in chondrocytes, followed by performing RT-qPCR and Western blot to analyze the expression of PTEN. The role of circZNF652 and PTEN in regulating the apoptosis of chondrocytes induced by LPS was analyzed by cell apoptosis assay. Results We found that circZNF652 was overexpressed in OA and positively correlated with PTEN mRNA. In chondrocytes, circZNF652 overexpression increased the expression of PTEN, and circZNF652 siRNA silencing decreased the expression of PTEN. Moreover, circZNF652 and PTEN positively regulated the apoptosis of chondrocytes induced by LPS. PTEN overexpression reversed the inhibitory effects of circZNF652 siRNA silencing on cell apoptosis. Conclusion CircZNF652E is overexpressed in OA and positively regulates LPS-induced apoptosis of chondrocytes by upregulating PTEN.

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Section: Introductionmentioning

confidence: 99%

Circular RNA circZNF652 is overexpressed in osteoarthritis and positively regulates LPS-induced apoptosis of chondrocytes by upregulating PTEN

Yuan

Zhang

Cai

et al. 2020

Preprint

View full text Add to dashboard Cite

show abstract

The role and function of long non-coding RNAs in osteoarthritis

Abbasifard

Kamiab

Bagheri‐Hosseinabadi

et al. 2020

Experimental and Molecular Pathology

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Circular RNA circZNF652 is overexpressed in osteoarthritis and positively regulates LPS-induced apoptosis of chondrocytes by upregulating PTEN

et al. 2021

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BackgroundCircular RNA circZNF652 promotes LPS-induced in ammation, which contributes to the development of osteoarthritis (OA), indicating the potential involvement of CRNDE in OA. This study was carried to explore the involvement of circZNF652 in OA. Methods RT-qPCR was performed to analyze the expression of circZNF652 and PTEN mRNA in synovial uid samples from 60 OA patients and 60 healthy controls. Correlations between circZNF652 and PTEN mRNA were analyzed by Pearson's correlation coe cient. Overexpression and siRNA silencing of circZNF652 were achieved in chondrocytes, followed by performing RT-qPCR and Western blot to analyze the expression of PTEN. The role of circZNF652 and PTEN in regulating the apoptosis of chondrocytes induced by LPS was analyzed by cell apoptosis assay. Results We found that circZNF652 was overexpressed in OA and positively correlated with PTEN mRNA. In chondrocytes, circZNF652 overexpression increased the expression of PTEN, and circZNF652 siRNA silencing decreased the expression of PTEN. Moreover, circZNF652 and PTEN positively regulated the apoptosis of chondrocytes induced by LPS. PTEN overexpression reversed the inhibitory effects of circZNF652 siRNA silencing on cell apoptosis. ConclusionCircZNF652E is overexpressed in OA and positively regulates LPS-induced apoptosis of chondrocytes by upregulating PTEN.

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Multiple joint osteoarthritis in the osteoarthritis initiative

Cited by 3 publications

References 0 publications

Circular RNA circZNF652 is overexpressed in osteoarthritis and positively regulates LPS-induced apoptosis of chondrocytes by upregulating PTEN

Circular RNA circZNF652 is overexpressed in osteoarthritis and positively regulates LPS-induced apoptosis of chondrocytes by upregulating PTEN

The role and function of long non-coding RNAs in osteoarthritis

Circular RNA circZNF652 is overexpressed in osteoarthritis and positively regulates LPS-induced apoptosis of chondrocytes by upregulating PTEN

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