The role and function of long non-coding RNAs in osteoarthritis

Abbasifard, Mitra; Kamiab, Zahra; Bagheri‐Hosseinabadi, Zahra; Sadeghi, Iman

doi:10.1016/j.yexmp.2020.104407

Cited by 24 publications

(18 citation statements)

References 53 publications

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“…This review focused on lncRNAs involved in this type of pain. Similar to lncRNAs in the PNI model, various lncRNAs may be differentially expressed and exert opposite effects in the pathogenesis of OA ( Abbasifard et al, 2020 ; Xie et al, 2020 ). Li et al (2018b) first found that the levels of lncRNA MEG3 increased in the articular tissue of an OA model after treatment with methylene blue, which improved pain sensitivity and reduced inflammatory pain in the OA model.…”

Section: Lncrnas and Osteoarthritis-induced Inflammatory Painmentioning

confidence: 99%

“…These results indicate that lncRNAs may regulate the development of OA-induced pain via different mechanisms. Notably, different lncRNAs may play opposite roles in the inflammatory process of OA ( Abbasifard et al, 2020 ; Xie et al, 2020 ); a similar phenomenon may appear in the development of OA-induced pain. The roles and mechanisms of different lncRNAs need to be validated.…”

Section: Lncrnas and Osteoarthritis-induced Inflammatory Painmentioning

confidence: 99%

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Roles of Long Non-coding RNAs in the Development of Chronic Pain

Jian

et al. 2021

Front. Mol. Neurosci.

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Chronic pain, a severe public health issue, affects the quality of life of patients and results in a major socioeconomic burden. Only limited drug treatments for chronic pain are available, and they have insufficient efficacy. Recent studies have found that the expression of long non-coding RNAs (lncRNAs) is dysregulated in various chronic pain models, including chronic neuropathic pain, chronic inflammatory pain, and chronic cancer-related pain. Studies have also explored the effect of these dysregulated lncRNAs on the activation of microRNAs, inflammatory cytokines, and so on. These mechanisms have been widely demonstrated to play a critical role in the development of chronic pain. The findings of these studies indicate the significant roles of dysregulated lncRNAs in chronic pain in the dorsal root ganglion and spinal cord, following peripheral or central nerve lesions. This review summarizes the mechanism underlying the abnormal expression of lncRNAs in the development of chronic pain induced by peripheral nerve injury, diabetic neuropathy, inflammatory response, trigeminal neuralgia, spinal cord injury, cancer metastasis, and other conditions. Understanding the effect of lncRNAs may provide a novel insight that targeting lncRNAs could be a potential candidate for therapeutic intervention in chronic pain.

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Section: Lncrnas and Osteoarthritis-induced Inflammatory Painmentioning

confidence: 99%

Section: Lncrnas and Osteoarthritis-induced Inflammatory Painmentioning

confidence: 99%

Roles of Long Non-coding RNAs in the Development of Chronic Pain

Jian

et al. 2021

Front. Mol. Neurosci.

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“…43 Moreover, Abbasifard et al also found that lncRNAs were involved in multiple pathological processes, including extracellular matrix (ECM) degradation, inflammatory responses, apoptosis and angiogenesis. 44 Recently, accumulating efforts have been made to investigate the clinical significance of lncRNAs in human cancers. 45 All the above findings may provide reliable and comprehensive evidence for clinical application of lncRNAs.…”

Section: Conclusion and Future Perspectivesmentioning

confidence: 99%

<p>Latest Advances of Long Non-Coding RNA SNHG5 in Human Cancers</p>

Han¹,

Shi²,

Cao³

et al. 2020

OTT

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Long non-coding RNAs (lncRNAs) have been potent regulators in the initiation and development of human cancers regarding their biological roles in the modulation of dosage compensation effect, epigenetics and cell differentiation. Recently, aberrant expression of lncRNA small nucleolar RNA host gene 5 (SNHG5) has been observed in various solid tumors, which was intently correlated with tumor range, metastasis, pathological stage and prognosis. Additional mechanical investigation disclosed that SNHG5 was involved in multiple cellular activities, including proliferation, migration, invasion, cell-cycle, apoptosis and autophagy, via targeting miRNAs, signaling pathways and other biological molecules or proteins. In this review, we summarized the latest advances made towards understanding the roles of SNHG5 in human cancers and further discussed potential methods that could be adopted for clinical interventions.

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“…According to the position of the protein-encoding genes in the genome, lncRNAs are divided into five types, namely, intronic, intergenic, bidirectional, sense and antisense ( Wang J. et al, 2019 ). More and more evidence argues that lncRNAs can act as an enhancer or suppressor to regulate the immune response at the epigenetic level, function as scaffold molecules through interactions with RNA-binding proteins in chromatin remodeling complexes ( Mathy and Chen, 2017 ), and then, are involved in many cellular and biological processes in MSDD, such as proliferation, apoptosis, differentiation, inflammation and ECM degradation ( Jiang et al, 2017 ; Li Z. et al, 2018 ; Abbasifard et al, 2020 ). Thus, it is important to develop lncRNA as a biomarker and therapeutic target for MSDD.…”

Section: Interactions Between Lncrna/circrna and Mirnamentioning

confidence: 99%

Interactions Among lncRNA/circRNA, miRNA, and mRNA in Musculoskeletal Degenerative Diseases

Song

Guo

et al. 2021

Front. Cell Dev. Biol.

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Musculoskeletal degenerative diseases (MSDDs) are pathological conditions that affect muscle, bone, cartilage, joint and connective tissue, leading to physical and functional impairments in patients, mainly consist of osteoarthritis (OA), intervertebral disc degeneration (IDD), rheumatoid arthritis (RA) and ankylosing spondylitis (AS). Long non-coding RNAs (lncRNAs) and circular RNAs (circRNAs) are novel regulators of gene expression that play an important role in biological regulation, involving in chondrocyte proliferation and apoptosis, extracellular matrix degradation and peripheral blood mononuclear cell inflammation. Research on MSDD pathogenesis, especially on RA and AS, is still in its infancy and major knowledge gaps remain to be filled. The effects of lncRNA/circRNA-miRNA-mRNA axis on MSDD progression help us to fully understand their contribution to the dynamic cellular processes, provide the potential OA, IDD, RA and AS therapeutic strategies. Further studies are needed to explore the mutual regulatory mechanisms between lncRNA/circRNA regulation and effective therapeutic interventions in the pathology of MSDD.

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The role and function of long non-coding RNAs in osteoarthritis

Cited by 24 publications

References 53 publications

Roles of Long Non-coding RNAs in the Development of Chronic Pain

Roles of Long Non-coding RNAs in the Development of Chronic Pain

<p>Latest Advances of Long Non-Coding RNA SNHG5 in Human Cancers</p>

Interactions Among lncRNA/circRNA, miRNA, and mRNA in Musculoskeletal Degenerative Diseases

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