Multifocal Pyogenic Granuloma-Like Kaposi Sarcoma

Abstract

Background: Kaposi sarcomais a low-grade malignant vascular lesion, which has different histological variants. Pyogenic granuloma-like Kaposi sarcoma is an unusual type of this tumor, which presents as anexophytic small nodule surrounded by an epidermal collaret mimicking pyogenic granuloma yet it has immunohistopathologic features of Kaposi sarcoma. Case Presentation: A 57-year old male with 2 exophytic lesions on the left hand and left foot for 3 months was presented to our center. Both lesions were excised and diagnosis of Kaposi sarcoma was confirmed by histopathology and immunohistochemistry. Human herpesvirus 8 DNA was detected by the polymerase chain reaction in the lesions. Conclusions: Immunostaining methods should be considered in pyogenic granuloma-like lesions with unusual presentation.

Polypoid Lesion on the Palm: Answer

“…distinguished from bacillary angiomatosis, as some examples of the latter can also demonstrate PG-like morphology. [3][4][5] Only 4 previously described PGLKS tumors were localized to the hand, with 2 on the palmar surface, as in our case. [3][4][5] Of interest, 80% of reported PGLKS tumors on the hand (including our case) presented as a de novo solitary polyp, 3,4 with only one report of multifocal disease (tumors localized to hand and foot).…”

“…[3][4][5] Only 4 previously described PGLKS tumors were localized to the hand, with 2 on the palmar surface, as in our case. [3][4][5] Of interest, 80% of reported PGLKS tumors on the hand (including our case) presented as a de novo solitary polyp, 3,4 with only one report of multifocal disease (tumors localized to hand and foot). 5 In all cases, typical patch, plaque or nodular KS lesions were not present at other cutaneous sites, highlighting the difficulty in diagnosing PGLKS on the basis of clinical features alone in this subtype.…”

“…[3][4][5] Of interest, 80% of reported PGLKS tumors on the hand (including our case) presented as a de novo solitary polyp, 3,4 with only one report of multifocal disease (tumors localized to hand and foot). 5 In all cases, typical patch, plaque or nodular KS lesions were not present at other cutaneous sites, highlighting the difficulty in diagnosing PGLKS on the basis of clinical features alone in this subtype. It has been suggested that PGLKS may be an under-reported clinicalhistopathologic entity, especially when presenting as a solitary polyp and/or localized on uncommon/atypical sites, such as the hand.…”

“…This is a rare clinical-histopathologic variant of KS, with less than 30 cases of PGLKS reported in the literature to date. [3][4][5] Similar to other KS variants, PGLKS is mostly commonly described on the lower limbs, including the foot. [3][4][5] Men are predominantly affected, with male-to-female ratio of 7.25:1.…”

“…[3][4][5] Similar to other KS variants, PGLKS is mostly commonly described on the lower limbs, including the foot. [3][4][5] Men are predominantly affected, with male-to-female ratio of 7.25:1. In previous reports, age range is wide (25-81 years), with a mean of 60 years.…”