Acute localized exanthematous pustulosis (ALEP) is a rare disease characterized by the acute onset of multiple localized non‐follicular, pinhead‐sized pustules. ALEP is considered a localized form of acute generalized exanthematous pustulosis but its pathogeny is not well identified. We performed a systematic review of the literature of all publications regarding ALEP cases using the term “acute localized exanthematous pustulosis,” to provide an update on this disease and its management. Results and conclusion ALEP is an uncommon skin condition attributed primarily to a hypersensitivity reaction to a systemic drug (classical or herbal); though a contact mechanism has been reported. It may be misdiagnosed as infectious or inflammatory disease but the clinico‐pathological correlation in addition to the rapid response to withdrawal of the culprit agent supports this diagnosis. The pathogenesis of ALEP is still unclear, and there are no standardized treatment guidelines to manage this disease. Both AGEP and ALEP have a good prognosis if an early diagnosis is made.
Giant-cell arteritis (GCA), also referred to as temporal arteritis, is the most common primary vasculitis of the elderly involving the extracranial branches of the carotid arteries, in particular, the temporal artery. Patients usually present with temporal headaches, visual impairment, fever, and scalp tenderness. Scalp necrosis associated with GCA is a rare occurrence with approximately 100 cases reported in the literature to date. It is a therapeutic emergency requiring urgent management as it may lead to irreversible loss of vision. To increase awareness of this severe complication, we report a patient with a scalp necrosis revealing a GCA.
A 23-year-old female patient consulted our department for burning sensation and painful tongue for the past 3 months. These burning sensations are aggravated on intake of hot and spicy foods. Patient reported no history of drug intake before. Examination revealed erythematous depapillated tongue on its dorsal surface surmounted by multiple white keratotic papules (Fig. 1).Dermoscopic examination revealed white patch with thin reticular striae surrounded with erythematous area and curved vessels (Fig. 2).The rest of the clinical examination didn't show any signs of associated buccal mucosa, ocular, cutaneous, or genital lesions.
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