Multi-enzyme mimetic ultrasmall iridium nanozymes as reactive oxygen/nitrogen species scavengers for acute kidney injury management

Zhang, Dongyang; Younis, Muhammad Rizwan; Liu, Hengke; Shan, Lei; Wan, Yilin; Qu, Junle; Lin, Jing; Huang, Peng

doi:10.1016/j.biomaterials.2021.120706

Cited by 83 publications

(63 citation statements)

References 45 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Furthermore, PVP-IrNPs could be easily excreted to urine by the kidney and exhibit lower systemic toxicity. Besides, Ir-oxide (IrOx) has been reported that acid-activated OXD-like and pH-dependent CAT-like functions for targeted tumor therapies [ 123 ]. At neutral normal tissues, the IrOx presented dominantly CAT-like activities.…”

Section: Iridium-based Nanozymesmentioning

confidence: 99%

Nanozymes-recent development and biomedical applications

et al. 2022

View full text Add to dashboard Cite

Nanozyme is a series of nanomaterials with enzyme-mimetic activities that can proceed with the catalytic reactions of natural enzymes. In the field of biomedicine, nanozymes are capturing tremendous attention due to their high stability and low cost. Enzyme-mimetic activities of nanozymes can be regulated by multiple factors, such as the chemical state of metal ion, pH, hydrogen peroxide (H2O2), and glutathione (GSH) level, presenting great promise for biomedical applications. Over the past decade, multi-functional nanozymes have been developed for various biomedical applications. To promote the understandings of nanozymes and the development of novel and multifunctional nanozymes, we herein provide a comprehensive review of the nanozymes and their applications in the biomedical field. Nanozymes with versatile enzyme-like properties are briefly overviewed, and their mechanism and application are discussed to provide understandings for future research. Finally, underlying challenges and prospects of nanozymes in the biomedical frontier are discussed in this review. Graphical Abstract

show abstract

Section: Iridium-based Nanozymesmentioning

confidence: 99%

Nanozymes-recent development and biomedical applications

et al. 2022

View full text Add to dashboard Cite

show abstract

“…Recently, ultrasmall polyvinylpyrrolidone‐coated iridium NPs (Ir NPs‐PVP) and ultrasmall copper‐based NPs (Cu 5.4 O) have been reported as multi‐enzyme mimetic to scavenge various ROS for the treatment of AKI. [ 43,248 ] The biocompatibility of NPs was assessed in healthy mice with immune system via intravenous injection. As for Ir NPs‐PVP, no significant weight loss was observed, which indicated the low systemic toxicity.…”

Section: Representative Biotherapeutic Applications Of Ros Scavenging Nanostructuresmentioning

confidence: 99%

“…Reproduced with permission. [ 248 ] Copyright 2021, Elsevier Ltd. B: a) In vivo toxicity of Cu 5.4 O to the kidney at 24 h after intravenous administration. b) Serum levels of liver function indicators: aspartate transaminase and alanine transaminase.…”

Section: Representative Biotherapeutic Applications Of Ros Scavenging Nanostructuresmentioning

confidence: 99%

Biocatalytic and Antioxidant Nanostructures for ROS Scavenging and Biotherapeutics

Wang

Zhu

Deng

et al. 2021

Adv Funct Materials

View full text Add to dashboard Cite

In human systems, reactive oxygen species (ROS) significantly affect different physiological activities and play critical roles in diverse living processes. It is widely known that excessive ROS generation in inflammatory tissues can further deteriorate the localized tissue injury and cause chronic diseases. Though promising for reducing ROS levels, many antioxidant molecules and natural enzymes suffer from abundant intrinsic limitations. Recently, a series of biocatalytic or antioxidant nanostructures have been designed with distinctive ROS scavenging capabilities, which show promising activities to overcome these kernel challenges. In this timely review, the most recent advances in engineering biocatalytic and antioxidant nanostructures for ROS scavenging are summarized. First, the ROS scavenging principles and corresponding methods for testing various enzymatic activities are carefully concluded. Subsequently, the rationally designed nanostructures with high ROS scavenging efficiencies are comprehensively discussed, especially on the catalytic activities, mechanisms, and structure‐function relationships. After that, the representative applications of these ROS scavenging nanostructures for diverse biotherapeutics are summarized in detail. At last, the primary challenges and future perspectives in this emerging research frontier have also been outlined. It is believed that this progress review will offer a cutting‐edge understanding and guidance to engineering future high‐performance ROS scavenging nanostructures for broad biotherapeutic applications.

show abstract

“…Among them, natural enzymes have played an important role in the scavenging of free radicals [5]. Inflammation can activate epithelial cells, neutrophils, and macrophages to produce various inflammatory cytokines and other inflammatory mediators, which further reduce the expression of enzymes or impair their radical scavenging function [6][7][8]. Failure to scavenge free radicals leads to an oxidative stress response and breaks the free radical production-scavenging balance, which causes oxidative damage to proteins, DNA, and lipids and further accelerates the progression of inflammation [9][10][11].…”

Section: Introductionmentioning

confidence: 99%

Biodegradable MoSe2-polyvinylpyrrolidone nanoparticles with multi-enzyme activity for ameliorating acute pancreatitis

et al. 2022

View full text Add to dashboard Cite

Exogenous antioxidant materials mimicking endogenous antioxidant systems are commonly used for the treatment of oxidative stress-induced injuries. Thus, artificial enzymes have emerged as promising candidates for balancing and treating the dysregulation of redox homeostasis in vivo. Herein, a one-pot hydrothermal strategy for the facile preparation of MoSe2-polyvinylpyrrolidone (PVP) nanoparticles (NPs) is reported. The synthesized NPs were biodegradable due to their exposure to oxygen and exhibited high stability. Moreover, they effectively mimicked various naturally occurring enzymes (including catalase, superoxide dismutase, peroxidase, and glutathione peroxidase) and scavenged free radicals, such as 3-ethylbenzothiazoline-6-sulfonic acid, ·OH, ·O2−, and 1,1-diphenyl-2-picrylhydrazyl radical. Further apoptosis detection studies revealed that MoSe2-PVP NPs significantly increased the cell survival probability in H2O2 in a concentration-dependent manner. The cytoprotective effect of MoSe2-PVP NPs was explored for an animal model of acute pancreatitis, which confirmed its remarkable therapeutic efficacy. Owing to the biodegradable and biocompatible nature of MoSe2-PVP NPs, the findings of this work can stimulate the development of other artificial nanoenzymes for antioxidant therapies. Graphical Abstract

show abstract

Multi-enzyme mimetic ultrasmall iridium nanozymes as reactive oxygen/nitrogen species scavengers for acute kidney injury management

Cited by 83 publications

References 45 publications

Nanozymes-recent development and biomedical applications

Nanozymes-recent development and biomedical applications

Biocatalytic and Antioxidant Nanostructures for ROS Scavenging and Biotherapeutics

Biodegradable MoSe2-polyvinylpyrrolidone nanoparticles with multi-enzyme activity for ameliorating acute pancreatitis

Contact Info

Product

Resources

About