Exogenous antioxidant materials mimicking endogenous antioxidant systems are commonly used for the treatment of oxidative stress-induced injuries. Thus, artificial enzymes have emerged as promising candidates for balancing and treating the dysregulation of redox homeostasis in vivo. Herein, a one-pot hydrothermal strategy for the facile preparation of MoSe2-polyvinylpyrrolidone (PVP) nanoparticles (NPs) is reported. The synthesized NPs were biodegradable due to their exposure to oxygen and exhibited high stability. Moreover, they effectively mimicked various naturally occurring enzymes (including catalase, superoxide dismutase, peroxidase, and glutathione peroxidase) and scavenged free radicals, such as 3-ethylbenzothiazoline-6-sulfonic acid, ·OH, ·O2−, and 1,1-diphenyl-2-picrylhydrazyl radical. Further apoptosis detection studies revealed that MoSe2-PVP NPs significantly increased the cell survival probability in H2O2 in a concentration-dependent manner. The cytoprotective effect of MoSe2-PVP NPs was explored for an animal model of acute pancreatitis, which confirmed its remarkable therapeutic efficacy. Owing to the biodegradable and biocompatible nature of MoSe2-PVP NPs, the findings of this work can stimulate the development of other artificial nanoenzymes for antioxidant therapies.
Graphical Abstract
In
this work, the advantages of in situ loading, heterojunction
construction, and facet regulation were integrated based on the poly-facet-exposed
BiOCl single crystal, and a facet-oriented supported heterojunction
of Cu2O and BiOCl was fabricated (Cu2O@BiOCl[100]).
The photocatalytic nitrogen reduction reaction (pNRR) activity of
Cu2O@BiOCl[100] was as high as 181.9 μmol·g–1·h–1, which is 4.09, 7.13,
and 1.83 times that of Cu2O, BiOCl, and Cu2O@BiOCl-ran
(Cu2O randomly supported on BiOCl). Combined with the results
of the photodeposition experiment, X-ray photoelectron spectroscopy
characterization, and DFT calculation, the mechanism of Cu2O@BiOCl[100] for pNRR was discussed. When Cu2O directionally
loaded on the [100] facet of BiOCl, electrons generated by Cu2O will be transmitted to the [100] facet of BiOCl through
Z-scheme electron transmission. Due to the directional separation
characteristics of charge in BiOCl, the electrons transmitted from
Cu2O are enriched on the [001] facet of BiOCl, which will
together with the original electrons generated by pristine BiOCl act
on pNRR, thus greatly improving the activity of photocatalytic ammonia
synthesis. Thus, a new construction scheme of biphasic semiconductor
heterojunction was proposed, which provides a reference research idea
for designing and synthesizing high-performance photocatalysts for
nitrogen reduction.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.