Biodegradable MoSe2-polyvinylpyrrolidone nanoparticles with multi-enzyme activity for ameliorating acute pancreatitis

Xie, Pei; Zhang, Liying; Shen, Hui; Wu, Huayue; Zhao, Jiulong; Wang, Shige; Hu, Liang‐Hao

doi:10.1186/s12951-022-01288-x

Cited by 30 publications

(14 citation statements)

References 51 publications

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“…[67][68][69] Hu et al reported that a polyvinylpyrrolidone-stabilized MoSe 2 nanoparticle (MoSe 2 -PVP NPs) could be easily prepared. 70 The MoSe 2 -PVP NPs effectively simulates various natural enzymes, and eliminates free radicals such as •OH, •O 2 − and 3-ethylbenzothiazoline-6-sulfonic acid. MoSe2-PVP NPs significantly increased the survival probability of cells in H 2 O 2 and had a significant protective effect on AP animal models.…”

Section: Inorganic Nanoparticlesmentioning

confidence: 99%

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A Mini-Review of Diagnostic and Therapeutic Nano-Tools for Pancreatitis

Zhang¹,

Li²,

Yang³

et al. 2022

IJN

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Pancreatitis is an inflammatory reaction of pancreatic tissue digestion, edema, bleeding and even necrosis caused by activation of pancreatin due to various causes. In particular, patients with severe acute pancreatitis (SAP) often suffer from secondary infection, peritonitis and shock, and have a high mortality rate. Chronic pancreatitis (CP) can cause permanent damage to the pancreas. Due to the innate characteristics, structure and location of the pancreas, there is no effective treatment, only relief of symptoms. Especially, AP is an unpredictable and potentially fatal disease, and the timely diagnosis and treatment remains a major challenge. With the rapid development of nanomedicine technology, many potential tools can be used to address this problem. In this review, we have introduced the pathophysiological processes of pancreatitis to understanding its etiology and severity. Most importantly, the current progress in the diagnosis and treatment tools of pancreatitis based on nanomedicine is summarized and prospected.

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Section: Inorganic Nanoparticlesmentioning

confidence: 99%

“…MoSe2-PVP NPs significantly increased the survival probability of cells in H 2 O 2 and had a significant protective effect on AP animal models. 70 Another example, Prussian blue, as an ancient dye, is a clinical antidote for radioactive element poisoning such as thallium. Prussian blue nanoparticles (PB…”

Section: Inorganic Nanoparticlesmentioning

confidence: 99%

A Mini-Review of Diagnostic and Therapeutic Nano-Tools for Pancreatitis

Zhang¹,

Li²,

Yang³

et al. 2022

IJN

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“…In normal organisms, the antioxidant enzyme system requires the participation of multiple enzymes to maintain redox homeostasis in cells. To simulate this multi-enzyme complex system, we prepared polyvinylpyrrolidone-modified molybdenum selenide nanoparticles (MoSe 2 -PVP NPs) by a hydrothermal one-pot method for the treatment of AP [ 115 ]. MoSe 2 -PVP NPs were prepared simply and efficiently, which exhibited good colloidal stability, biocompatibility, and biodegradability, and mimicked the activities of native CAT, SOD, POD, and GPx.…”

Section: Antioxidant Nanomaterials For Apmentioning

confidence: 99%

“…( d ) Histogram of apoptosis and necrosis in untreated and MoSe 2 -PVP NPs-treated RAW264.7 cells ( e ) of cell apoptosis and necrosis distribution in untreated and MoSe 2 -PVP NPs-treated RAW264.7 cells. *** p < 0.001, Representative graphics are shown, Reprinted from [ 115 ]. Copyright 2022.…”

Section: Figures Scheme and Tablesmentioning

confidence: 99%

Research Progress of Antioxidant Nanomaterials for Acute Pancreatitis

et al. 2022

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Acute pancreatitis (AP) is a complex inflammatory disease caused by multiple etiologies, the pathogenesis of which has not been fully elucidated. Oxidative stress is important for the regulation of inflammation-related signaling pathways, the recruitment of inflammatory cells, the release of inflammatory factors, and other processes, and plays a key role in the occurrence and development of AP. In recent years, antioxidant therapy that suppresses oxidative stress by scavenging reactive oxygen species has become a research highlight of AP. However, traditional antioxidant drugs have problems such as poor drug stability and low delivery efficiency, which limit their clinical translation and applications. Nanomaterials bring a brand-new opportunity for the antioxidant treatment of AP. This review focuses on the multiple advantages of nanomaterials, including small size, good stability, high permeability, and long retention effect, which can be used not only as effective carriers of traditional antioxidant drugs but also directly as antioxidants. In this review, after first discussing the association between oxidative stress and AP, we focused on summarizing the literature related to antioxidant nanomaterials for the treatment of AP and highlighting the effects of these nanomaterials on the indicators related to oxidative stress in pathological states, aiming to provide references for follow-up research and promote clinical application.

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“…Specifically, this ability has a significant impact on the kinetics of polymerization of HEMA in the presence of PVP (through the formation stage of a complex with charge transfer) and the formation of the polymer matrix structure [ 42 ]. At the same time, the use of PVP opens up additional opportunities for modification of various substances [ 43 , 44 ] and improvement of technologies for obtaining new functional materials with a set of unique properties [ 45 , 46 ].…”

Section: Introductionmentioning

confidence: 99%

New Materials Based on Polyvinylpyrrolidone-Containing Copolymers with Ferromagnetic Fillers

et al. 2022

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The article investigates the peculiarities of the effect of ferromagnetic fillers (FMFs) of various natures (Ni, Co, Fe, FeCo, SmCo5) on the formation of the structure and properties of 2-hydroxyethylmethacrylate (HEMA) with polyvinylpyrrolidone (PVP) copolymers. The composites were characterized using FTIR-spectroscopy, SEM, DMTA, magnetometry of vibrating samples, specific electrical resistivity studies, and mechanical and thermophysical studies. The formation of a grafted spatially crosslinked copolymer (pHEMA-gr-PVP) was confirmed and it was established that the FMF introduction of only 10 wt.% into the copolymer formulation increased the degree of crosslinking of the polymer network by three times. The surface hardness of composites increased by 20–25%. However, the water content decreased by 16–18% and lay within 42–43 wt.%, which is a relatively high number. The heat resistance of dry composites was characterized by Vicat softening temperature, which was 39–42 °C higher compared to the unfilled material. It was established that the obtained composites were characterized by a coercive force of 200 kA × m−1 and induction of a magnetic field at the poles of 4–5 mT and 10–15 mT, respectively. The introduction of FMF particles into pHEMA-gr-PVP copolymers, which, in the dry state, are dielectrics, provides them with electrical conductivity, which was evaluated by the specific volume resistance. Depending on the FMF nature and content, as well as their orientation in the magnetic field, the resistance of filled materials could be regulated within 102–106 Ohm·m. Therefore, the modification of HEMA with PVP copolymers by ferromagnetic fillers of various natures provides the possibility of obtaining materials with unique predicted properties and expands the fields of their use, for instance as magnetic sorbents for various applications, as well as the possibilities associated with their being electrically conductive materials that can respond by changing of electrical conductivity, depending on various factors.

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Biodegradable MoSe2-polyvinylpyrrolidone nanoparticles with multi-enzyme activity for ameliorating acute pancreatitis

Cited by 30 publications

References 51 publications

A Mini-Review of Diagnostic and Therapeutic Nano-Tools for Pancreatitis

A Mini-Review of Diagnostic and Therapeutic Nano-Tools for Pancreatitis

Research Progress of Antioxidant Nanomaterials for Acute Pancreatitis

New Materials Based on Polyvinylpyrrolidone-Containing Copolymers with Ferromagnetic Fillers

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