MRI Dosimetry: A Fast Quantitative MRI Method to Determine 3D Absorbed Dose Distributions

Calmet, Chantal; Vincensini, D.; Bonnet, Jacques; Bertino, Catherine; Catala, A.; Martínez, M. Vega; Joffre, F.

doi:10.1097/00004424-199903000-00014

Cited by 4 publications

(1 citation statement)

References 14 publications

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“…Specifically, HIR generated radioactive FH NPs offer multimodal imaging such as PET 27,29,43 and MRI [22][23][24][25] and the simultaneous MRI would be leveraged with HIR radiometal-FH nano-platform for three-dimensional radiation dosimetry studies, an area with important clinical significance. 80…”

Section: Significance Of Chelate-free Hir Radiolabelingmentioning

confidence: 99%

<p>A Chelate-Free Nano-Platform for Incorporation of Diagnostic and Therapeutic Isotopes</p>

Gholami¹,

Josephson²,

Akam³

et al. 2020

IJN

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Purpose: Using our chelate-free, heat-induced radiolabeling (HIR) method, we show that a wide range of metals, including those with radioactive isotopologues used for diagnostic imaging and radionuclide therapy, bind to the Feraheme (FH) nanoparticle (NP), a drug approved for the treatment of iron anemia. Material and methods: FH NPs were heated (120°C) with nonradioactive metals, the resulting metal-FH NPs were characterized by inductively coupled plasma mass spectrometry (ICP-MS), dynamic light scattering (DLS), and r 1 and r 2 relaxivities obtained by nuclear magnetic relaxation spectrometry (NMRS). In addition, the HIR method was performed with [ 90 Y]Y 3+ , [ 177 Lu]Lu 3+ , and [ 64 Cu]Cu 2+ , the latter with an HIR technique optimized for this isotope. Optimization included modifying reaction time, temperature, and vortex technique. Radiochemical yield (RCY) and purity (RCP) were measured using size exclusion chromatography (SEC) and thin-layer chromatography (TLC). Results: With ICP-MS, metals incorporated into FH at high efficiency were bismuth, indium, yttrium, lutetium, samarium, terbium and europium (>75% @ 120 o C). Incorporation occurred with a small (less than 20%) but statistically significant increases in size and the r 2 relaxivity. An improved HIR technique (faster heating rate and improved vortexing) was developed specifically for copper and used with the HIR technique and [ 64 Cu] Cu 2+. Using SEC and TLC analyses with [ 90 Y]Y 3+ , [ 177 Lu]Lu 3+ and [ 64 Cu]Cu 2+ , RCYs were greater than 85% and RCPs were greater than 95% in all cases. Conclusion: The chelate-free HIR technique for binding metals to FH NPs has been extended to a range of metals with radioisotopes used in therapeutic and diagnostic applications. Cations with f-orbital electrons, more empty d-orbitals, larger radii, and higher positive charges achieved higher values of RCY and RCP in the HIR reaction. The ability to use a simple heating step to bind a wide range of metals to the FH NP, a widely available approved drug, may allow this NP to become a platform for obtaining radiolabeled nanoparticles in many settings.

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Section: Significance Of Chelate-free Hir Radiolabelingmentioning

confidence: 99%

<p>A Chelate-Free Nano-Platform for Incorporation of Diagnostic and Therapeutic Isotopes</p>

Gholami¹,

Josephson²,

Akam³

et al. 2020

IJN

View full text Add to dashboard Cite

show abstract

Magnetic resonance imaging measurements of vascular permeability and extracellular volume fraction of breast tumors by dynamic Gd-DTPA-enhanced relaxometry

Vincensini

Dedieu

Éliat³

et al. 2007

Magnetic Resonance Imaging

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Rapid relaxation times measurements by MRI: an in vivo application to contrast agent modeling for muscle fiber types characterization

Dedieu

Fau²,

Otal³

et al. 2000

Magnetic Resonance Imaging

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MRI Dosimetry: A Fast Quantitative MRI Method to Determine 3D Absorbed Dose Distributions

Abstract: These preliminary results support the feasibility of the proposed technique for accurate MRI dosimetry studies and also have potential for various clinical quantitative MRI applications.

Cited by 4 publications

References 14 publications

<p>A Chelate-Free Nano-Platform for Incorporation of Diagnostic and Therapeutic Isotopes</p>

<p>A Chelate-Free Nano-Platform for Incorporation of Diagnostic and Therapeutic Isotopes</p>

Magnetic resonance imaging measurements of vascular permeability and extracellular volume fraction of breast tumors by dynamic Gd-DTPA-enhanced relaxometry

Rapid relaxation times measurements by MRI: an in vivo application to contrast agent modeling for muscle fiber types characterization

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