Magnetic resonance imaging measurements of vascular permeability and extracellular volume fraction of breast tumors by dynamic Gd-DTPA-enhanced relaxometry

Vincensini, D.; Dedieu, V.; Éliat, Pierre-Antoine; Vincent, Corine; Bailly, C; Certaines, J. de; Joffre, F.

doi:10.1016/j.mri.2006.10.016

Cited by 31 publications

(26 citation statements)

References 43 publications

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“…K trans is varied between 0.02 and 1.2 min −1 , covering ranges from other simulation [1,23] or clinical studies [15,38] with Gd-DTPA. Tissue concentration curves for ν e = 0.5 and ν e = 0.3(D = 0.1mM kg −1 ) are generated according to the Tofts model (Eq.…”

Section: Maximum Likelihood Estimator For Kinetic Modellingmentioning

confidence: 99%

Precision analysis of kinetic modelling estimates in dynamic contrast enhanced MRI

Naeyer

Deene

Ceelen

et al. 2011

Magn Reson Mater Phy

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Section: Maximum Likelihood Estimator For Kinetic Modellingmentioning

confidence: 99%

Precision analysis of kinetic modelling estimates in dynamic contrast enhanced MRI

Naeyer

Deene

Ceelen

et al. 2011

Magn Reson Mater Phy

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“…The sequence parameters were chosen on the basis of MR protocol used in clinic practice for breast [21,27,28]. The fixed parameters were: TR/TE = 9.8/4.76 ms, acquisition matrix 128 Â 256, slice thickness 2 mm, gap 0 mm, pixel spacing 1:45 Â 1:45 mm 2 .…”

Section: Flash Acquisitionsmentioning

confidence: 99%

“…Up to now, there is no study that evaluates the accuracy of CA concentration measurement under TWIST acquisition. In contrast, the wellknown sequence for spoiled gradient echo known as Fast Low Angle SHot (FLASH) has been commonly used for CA quantification in DCE-MRI [11,[21][22][23]. However, as far as the authors knowledge, there is no comparison between these two sequences in terms of CA quantification.…”

Section: Introductionmentioning

confidence: 99%

Accuracy of Contrast Agent Quantification in MRI: A Comparison Between Two k-space Sampling Schemes

2015

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Dynamic contrast-enhanced magnetic resonance imaging (DCE MRI) plays an important role in many applications, such as perfusion imaging in oncology. Several aspects of data acquisition should be taken into account when developing protocols for DCE MRI both to facilitate integration of results from multiple institutions and to ensure that the data reflect the underlying physiology as accurately as possible.In this study we focused on the trade-off between accurate contrast agent (CA) quantification ad temporal resolution. The commonly used spoiled gradient-echo k-space scheme known as Fast Low Angle SHot (FLASH) can suffer from low temporal resolution if a large field of view must be scanned. Recently, a k-space under-sampling and data-sharing method known as Time-resolved angiography With Stochastic Trajectories (TWIST) has been proposed to obtain high temporal resolution without sacrificing the spatial resolution. However, the losses in CA quantification have not been analyzed yet.The aim of this study was to evaluate the accuracy of TWIST CA quantification with respect to FLASH.Seven vials containing different Gd-DTPA solutions were prepared. Images were acquired using breast coils and several combinations of the different parameters of the two schemes analyzed. Quantification accuracy has been evaluated in terms of relative error and standard deviation. Also the repeatability for both sequence was evaluated on ten measures.The accuracy of CA quantification with both sequences depends on the specific amount of Gd-DTPA present in the prepared solutions.However, our results show that FLASH and TWIST give comparable accurac

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“…In blood, a high arterial concentration, up to 10 mM of the concerned Gd-chelates can be expected, while in tumor tissue, a concentration range up to 2 mM is assumed (11,13,17). For blood, a T 10 -value of 1250 ms (at 1.5 T) is assumed (18) while for tumor tissue T 10 is set to 675 ms (19). For all conversion equations, the knowledge of T 20 * and M 0 is irrelevant.…”

Section: Simulationsmentioning

confidence: 99%

First order correction for T₂*‐relaxation in determining contrast agent concentration from spoiled gradient echo pulse sequence signal intensity

Naeyer

Debergh

Deene

et al. 2011

Magnetic Resonance Imaging

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Purpose: To investigate the accuracy of a method neglecting T 2 *-relaxation, for the conversion of spoiled gradient echo pulse sequence signal intensity to contrast agent (CA) concentration, in dynamic contrast enhanced MRI studies. In addition a new closed form conversion expression is proposed that accounts for a first order approximation of T 2 *-relaxation. Materials and Methods:The accuracy of both conversion methods is compared theoretically by means of simulations for four pulse sequences from literature. Both methods are tested in vivo against the numerical conversion method for measuring the arterial input function in mice.Results: Simulations show that the T 2 *-neglecting method underestimates typical tissue CA concentrations (0 mM to 2 mM) up to 6%, while the errors for arterial concentrations (0 mM to 10 mM) range up to 43%. The results from our first order method are numerically indistinguishable from the simulation input values in tumor tissue, while for arterial concentrations the error is reduced up to a factor 10. In vivo, peak Gd-DOTA concentration is underestimated up to 14% with the T 2 *-neglecting method and up to 0.9% with our first order method. Conclusion:Our conversion method reduces the underestimation of CA concentration severely in a broad physiological concentration range and is easy to perform in any clinical setting.

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Magnetic resonance imaging measurements of vascular permeability and extracellular volume fraction of breast tumors by dynamic Gd-DTPA-enhanced relaxometry

Cited by 31 publications

References 43 publications

Precision analysis of kinetic modelling estimates in dynamic contrast enhanced MRI

Precision analysis of kinetic modelling estimates in dynamic contrast enhanced MRI

Accuracy of Contrast Agent Quantification in MRI: A Comparison Between Two k-space Sampling Schemes

First order correction for T₂*‐relaxation in determining contrast agent concentration from spoiled gradient echo pulse sequence signal intensity

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Magnetic resonance imaging measurements of vascular permeability and extracellular volume fraction of breast tumors by dynamic Gd-DTPA-enhanced relaxometry

Cited by 31 publications

References 43 publications

Precision analysis of kinetic modelling estimates in dynamic contrast enhanced MRI

Precision analysis of kinetic modelling estimates in dynamic contrast enhanced MRI

Accuracy of Contrast Agent Quantification in MRI: A Comparison Between Two k-space Sampling Schemes

First order correction for T2*‐relaxation in determining contrast agent concentration from spoiled gradient echo pulse sequence signal intensity

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First order correction for T₂*‐relaxation in determining contrast agent concentration from spoiled gradient echo pulse sequence signal intensity