Morphology of electrospun nanofibres of polyhydroxybutyrate

Olkhov, A. A.; Староверова, О. В.; Иорданский, А. Л.; Заиков, Г. Е.

doi:10.1063/1.4876902

Cited by 7 publications

(6 citation statements)

References 1 publication

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“…As was stated in [11] , polymers may have various crystalline modifications with identical crystallographic parameters of the unit cell, but different energy levels.…”

Section: Resultsmentioning

confidence: 95%

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Morphology of poly(3-hydroxybutyrate)–polyvinyl alcohol extrusion films

Olkhov¹,

Иорданский

Danko

2015

Journal of Polymer Engineering

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Abstract The morphology of extruded films based on blends of polyvinyl alcohol (PVA) and poly(3-hydroxybutyrate) (PHB) was studied for various compositions. The methods of differential scanning calorimetry (DSC) and X-ray analysis were used. The phase-sensitive characteristics of the composite films, diffusion and water vapor permeability were also investigated. Processes of binding of water and swelling cause the first areas; processes of a relaxation and transition of structure of composites to an equilibrium condition, the second. In addition, the tensile modulus and relative elongation-at-break were measured. Changes in the glass transition temperature (Tg) of the blends and constant melting points of the components show their partial compatibility in intercrystalline regions. At a content of PHB in the composite films equal to 20–30% wt., the mechanical characteristics and water diffusion coefficients are dramatically changed. This fact, along with the analysis of the X-ray diffractograms, indicates a phase inversion in the above narrow concentration interval. The complex pattern of the kinetic curves of water vapor permeability is likely to be related to additional crystallization, which is induced in the composite films in the presence of water.

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“…As was stated in [11] , polymers may have various crystalline modifications with identical crystallographic parameters of the unit cell, but different energy levels.…”

Section: Resultsmentioning

confidence: 95%

“…The PHB-fibers shape a structure in the PVA-phase in direct extrusion (see Figure 4 ). This can be seen in Figure 4C and D. Fiber formation in mixtures of polymers in the melt flow is common [11,13,14] .…”

Section: Pva:phb (%)mentioning

confidence: 94%

Morphology of poly(3-hydroxybutyrate)–polyvinyl alcohol extrusion films

Olkhov¹,

Иорданский

Danko

2015

Journal of Polymer Engineering

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“…The dependence of structure and properties of fibrous materials on the basis of PHB on technological parameters was described in previous articles . It was found that the smaller fiber diameter and the greater fiber packing density permitted more cells to be detected after inoculation and culture in the matrix.…”

Section: Resultsmentioning

confidence: 99%

“…The total tensile strength of the polyamide body is 16 N, which exceeds the maximum tensile load for an Achilles tendon of laboratory rats. According to the previous results, fibers with a diameter of 100–900 nm with a packing density of about 10% were used in the developed implant (Fig. ).…”

Section: Resultsmentioning

confidence: 99%

“…The dependence of structure and properties of fibrous materials on the basis of PHB on technological parameters was described in previous articles. [15][16][17] It was found that the smaller fiber diameter and the greater fiber packing density permitted more cells to be detected after inoculation and culture in the matrix. These results reflected both the efficiency of cell retention in the matrix during inoculation and the growth activity of cells in the matrix.…”

Section: Resultsmentioning

confidence: 99%

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Composite tendon implant based on nanofibrillar polyhydroxybutyrate and polyamide filaments

Olkhov

Гурьев

Акатов

et al. 2018

J Biomedical Materials Res

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The composite material based on reinforcement of polyamide filaments enclosed by a nonwoven matrix of nanoscaled bioresorbable poly(3-hydroxybutyrate) fibers was developed for application as an artificial ligament implant. The aim of this study was to investigate biodegradability and biocompatibility of the developed implant, as well as its stress-strain properties. The study results show the polyamide core of the implant has stress-strain properties comparable with a natural ligament. Simultaneously, the polyhydroxybutyrate external layer provides high biocompatibility and bioresorbability of the developed implant. The material has proven to be effective under in vivo tests with experimental rats as a ligament replacement for damaged Achilles tendons. Due to cell attachment and growth on the fibrous matrix during 5 weeks postsurgery, regenerated connective tissue was formed substituting for the polymeric implant, which confirmed its efficiency in contrast to the polyamide filament implant with a much longer resorption time. The results obtained indicate application prospects of polyamide-polyhydroxybutyrate implants for reconstructive surgery. © 2018 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 106A: 2708-2713, 2018.

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