Composite tendon implant based on nanofibrillar polyhydroxybutyrate and polyamide filaments

Abstract

The composite material based on reinforcement of polyamide filaments enclosed by a nonwoven matrix of nanoscaled bioresorbable poly(3-hydroxybutyrate) fibers was developed for application as an artificial ligament implant. The aim of this study was to investigate biodegradability and biocompatibility of the developed implant, as well as its stress-strain properties. The study results show the polyamide core of the implant has stress-strain properties comparable with a natural ligament. Simultaneously, the polyhydroxybutyrate external layer provides high biocompatibility and bioresorbability of the developed implant. The material has proven to be effective under in vivo tests with experimental rats as a ligament replacement for damaged Achilles tendons. Due to cell attachment and growth on the fibrous matrix during 5 weeks postsurgery, regenerated connective tissue was formed substituting for the polymeric implant, which confirmed its efficiency in contrast to the polyamide filament implant with a much longer resorption time. The results obtained indicate application prospects of polyamide-polyhydroxybutyrate implants for reconstructive surgery. © 2018 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 106A: 2708-2713, 2018.

Characterization and Evaluation of Controlled Antimicrobial Release from Petrochemical (PU) and Biodegradable (PHB) Packaging

“…Equation (5) reflects the relation between the kinetic and diffusion constants, and thus provides another way to evidence that the CHD transport in the system is complicated by the degradation process. As was shown previously in [15,17,65], films, microspheres, ultrathin fibrils of PHB, and its blends with PLA or chitosan slowly degrade in aqueous media in accordance with a zero-order equation. Moreover, recent studies of degradation in a hydrolytic medium or in the presence of enzymes showed that the surface of the biopolymer is involved in the loss of weight of PHB (S-type degradation) [57].…”

“…Biocompatibility observed at therapeutic and clinical levels allows PHB to be applied as prosthesis, heart valves and stents, bone drug release systems, surgical threads, fibrillar implants, scaffolds in tissue engineering, and other uses [14,15,16,17,18]. Importantly, all the representatives of PHAs, including PHB, are biocompatible with cells and tissues, and hence PHB-based food packaging can be in long-term contact with meat, fish and other food components without tangible damage.…”

Advanced Nanofiber-Based Scaffolds for Achilles Tendon Regenerative Engineering

“…One strategy is to create multiscale nanofibrous textile-based scaffolds using strands or yarns of nanofibers ( Almeida et al, 2019 ; Chen et al, 2021d ; Ma et al, 2022 ). Another method is to coat the fabric with nanofibers ( Chen L. et al, 2020 ; Olkhov et al, 2018 ). Nanofibrous strands or yarns have the potential to reconstruct the structure of natural collagen fibers ( Figure1 ) in tendon nanofibrous to microfibrous construction ( Mouthuy et al, 2015 ; Cai et al, 2020 ).…”

In vitro characterization of a synthetic polyamide-based erodible compact disc for extended drug release

“…They are constantly in high demand and scientist are seeking additional polymeric carriers for this application [2]. Researchers have documented the attractive clinical application, biocompatibility and potent drug release modulating properties of different aliphatic polyamides [29][30][31][32][33][34][35][36][37][38][39][40][41][42][43][44]. Yet, there is still not much information regarding their use as extended release drug carriers.…”