Structure formation in fibrous materials based on poly-3-hydroxybutyrate for traumatology

Olkhov, A. A.; Sklyanchuk, E. D.; Староверова, О. В.; Abbasov, T. A.; Guryev, Valentin; Акатов, В. С.; Fadeyeva, I. S.; Фесенко, Н. И.; Filatov, Yu. N.; Иорданский, А. Л.

doi:10.1063/1.4932857

Cited by 2 publications

(1 citation statement)

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“…Fiber fabrication is a fascinating technology and is widely used for specialized applications in diverse disciplines including: automobile, air and space industries, and biomedical and tissue engineering [1][2][3][4][5][6][7][8]. Due to its critical role in the production of three dimensional (3D) structures, such fiber fabrication technologies have opened new avenues, specifically for designing novel and smart fibrous structures with various functionalities and engineered properties [9][10][11][12][13][14]. For instance, 3D fibrous structures have been shown to be extremely promising in fabricating tissue-engineered structures for governing the fate of stem cells for many therapeutic applications [5,6,[15][16][17][18].…”

Section: Introductionmentioning

confidence: 99%

Fabricating and controlling PCL electrospun microfibers using filament feeding melt electrospinning technique

Ahsani

Yao

et al. 2016

J. Micromech. Microeng.

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The process of melt electrospinning has received noteworthy attention due to its ability to fabricate micro scaled polymer fibers. Recently, a melt electrospinning process has been attracting attention for biomedical applications, in particular with scaffold fabrication for tissue engineering. In order to enhance cell attachment and proliferation on scaffolds, it is important to control fiber diameters to create an environment to which cells can attach, grow, and proliferate with ease. However, because electrospinning is a process with many parameters, it is particularly difficult to precisely control the diameter of the resulting fibers. Also, polymer powders or pellets melted in nozzles are typically used for melt electrospinning. However, a filament feeding melt electrospinning process has not been yet been implemented. In this study, we developed a melt electrospinning device which can feed PCL (Polycaprolactone, Mw: 80 000 g mol−1) filaments for advanced electrospun fiber diameter control. The PCL filaments were first fabricated by a small scale micro-compounder and then fed into the melting chamber of the electrospinning device. The system was then heated to a desired temperature, and the melt was extruded through a nozzle. The potential difference between the nozzle and counter electrode then drew down the PCL extrudate, creating fine microfibers. Temperature was controlled and monitored via a customized temperature control system. In order to control the dispensing of the PCL filaments, a customized control algorithm using NI (National Instruments) LabVIEW was used. In order to actively cool PCL filaments, a miniature computer fan was attached on the side of the melting chamber so that the filaments would not buckle. This paper reveals the investigation of significant process parameters that influence fiber diameters and their optimization. For instance, applied voltages, distances between the nozzle and a counter electrode, processing temperatures, and polymer resin flowrates were varied. We also studied and summarized the effect of duty cycle—a ratio of forward and backward motions of the filament within a cycle time—for advanced fiber diameter control. Moreover, the relationship between a flow rate and a duty cycle and their influences on a fiber diameter were studied.

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