Monoamine oxidase levels in females: Relationships to sensation seeking, alcohol misuse, physical fitness, and menstrual cycle

Grange, Linda La; Jones, Troy Don; Reyes, Edward; Ott, Stephanie

doi:10.1016/0191-8869(93)90313-r

Cited by 6 publications

(1 citation statement)

References 29 publications

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“…Patterns of alcohol use, similar to the type 1/2 concept, have also been demonstrated in monkeys (Higley and Linnoila, 1997). When studies have been performed on female alcoholics, this pattern has, however, not been found, or has been much more unclear (Sandahl et al, 1987;Calhoon-La Grange et al, 1993;Meszaros et al, 1999). Instead, in a number of studies, female alcoholics in general have been shown to differ from controls, both in the direction of increased sensation-seeking and impulsiveness, as was the case with male type 2 alcoholics, and in the direction of increased somatic anxiety (Hallman et al, 1991;Pulkkinen et al, 2000;E.…”

Section: Introductionmentioning

confidence: 99%

Female Alcoholism: Differences Between Female Alcoholics With and Without a History of Additional Substance Misuse

Hallman

Persson²,

Klinteberg³

2001

Alcohol and Alcoholism

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The purpose of the present study was to investigate personality traits and platelet monoamine oxidase (MAO) activity, as well as occurrence of personality disorder criteria, family characteristics, and criminal activity as related to misuse pattern in a sample of female in-patients with severe alcohol dependence. In accordance with theoretical assumptions and empirical findings of underlying neurobiological correlates of disinhibition in individuals with double or multiple misuse patterns, the female alcoholics were divided into subgroups with: (1) alcohol as their single drug of misuse (ALC; n = 16); (2) a history of additional substance misuse (ALC-DRUG; n = 11). Platelet MAO activity of the female subgroups was studied in comparison to a control group of non-clinical female subjects. Marked differences were obtained between the two subgroups. The ALC-DRUG females scored significantly higher with regard to Karolinska Scales of Personality (KSP) impulsiveness, anxiety-related traits, and non-conformity, displayed higher frequency of depression in first degree relatives, were more frequently involved in criminal activity, and more frequently diagnosed for any personality disorder according to DSM-IV, axis II. Finally, the ALC-DRUG females displayed significantly lower platelet MAO activity than controls. In conclusion, the results support the usefulness of a classification of severe alcoholic female subjects according to having/not having a history of additional substance misuse. The present female alcoholics with a history of additional misuse formed a group of individuals fulfilling the criteria similar for male type 2 alcoholism.

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