Platelet monoamine oxidase activity and temperament and personality in adolescent female substance abusers

Mezzich, Ada C.; Tarter, Ralph E.; Moss, Howard B.; Yao, Jeffrey; Hsieh, Ya-Chen; Kirisci, Levent

doi:10.1016/0191-8869(94)90068-x

Cited by 5 publications

(3 citation statements)

References 38 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In an examination of children with an alcoholic parent, the level of the child's externalizing behavior was inversely correlated with that child's level of whole blood 5‐HT 256, 257 . Askenazy et al 258 found that platelet 5‐HT concentrations were higher in those with greater impulsivity, and Mezzich and colleagues 259 reported that for adolescents with SUD, platelet MAO activity corresponded to difficult temperament. In addition, certain 5‐HT transporter polymorphisms 260 and 5‐HT transporter gene combinations 261 appear to increase the risk for SUD, especially alcohol‐related problems.…”

Section: The Neurobiology Of Risk For Sud In Human Adolescentsmentioning

confidence: 99%

Neurobiological Processes in Adolescent Addictive Disorders

2008

View full text Add to dashboard Cite

The purpose of this review is to summarize the neurobiological factors involved in the etiology of adolescent addiction and present evidence implicating various mechanisms in its development. Adolescents are at heightened risk for experimentation with substances, and early experimentation is associated with higher rates of SUD in adulthood. Both normative (e.g., immature frontal-limbic connections, immature frontal lobe development) and non-normative (e.g., lowered serotonergic function, abnormal hypothalamic-pituitary-adrenal axis function) neurobiological developmental factors can predispose adolescents to a heightened risk for SUD. In addition, a normative imbalance in the adolescent neurobiological motivational system may be caused by the relative underdevelopment of suppressive mechanisms when compared to stimulatory systems. These neurobiological liabilities may correspond to neurobehavioral impairments in decision-making, affiliation with deviant peers and externalizing behavior; these and other cognitive and behavioral traits converge with neurobiological factors to increase SUD risk. The progression to SUD acts as an amplifying feedback loop, where the development of SUD results in reciprocal impairments in neurobehavioral and neurobiological processes. A clearer understanding of adolescent neurobiology is a necessary step in the development of prevention and treatment interventions for adolescent SUD.

show abstract

Section: The Neurobiology Of Risk For Sud In Human Adolescentsmentioning

confidence: 99%

Neurobiological Processes in Adolescent Addictive Disorders

2008

View full text Add to dashboard Cite

show abstract

“…The SUD group also had significantly lower EF and difficult temperament scores compared with the control group (see Table 3). In order to avoid multiple publications of the same data, interested readers are referred to other sources for more detailed information on group differences data (Giancola & Mezzich, 2000; Mezzich, Tarter et al, 1994). Inasmuch as the purpose of this study was not to compare the SUD and the control group, they were combined for all remaining analyses.…”

Section: Group Differencesmentioning

confidence: 99%

Executive functioning, temperament, and drug use involvement in adolescent females with a substance use disorder

Giancola

Mezzich

2003

Child Psychology Psychiatry

Self Cite

View full text Add to dashboard Cite

show abstract

“…However, other studies have not found associations between MAO activity and aggression, including a study of adolescent girls with and without substance‐abuse problems . Teacher ratings of aggression did not differ significantly between high and low MAO adolescents; ratings relevant to ADHD did differ, with low MAO related to higher hyperactivity and concentration difficulties .…”

Section: Literature Reviewmentioning

confidence: 78%

Serotonin and aggressive behaviour in children and adolescents: a systematic review

Runions

Morandini

Rao

et al. 2019

Acta Psychiatr Scand

View full text Add to dashboard Cite

aggressive behaviour in children and adolescents: a systematic review.Objective: The role of serotonin (5-HT) in human aggression has been the subject of a large number of studies, mostly with adults. Meta-analyses indicate a small but significant inverse relationship between central nervous 5-HT availability and aggression, but genetically informed studies suggest two pathways: one to reactive aggression and the other to proactive aggression. Method: We conducted a systemic review on central nervous 5-HT function in children and adolescents, with attention to the function of aggression. Results: In total, 675 articles were screened for relevance, with 45 reviewed. These included blood assays (e.g. plasma, 5-HIAA; platelet 5-HTR 2A ), epigenetic studies, retrospective PET studies and 5-HT challenge paradigms (e.g. tryptophan depletion). Overall, findings were mixed, with support both for negative and for positive associations of central nervous 5-HT function with aggression in children and adolescents. Conclusion: We propose factors that may be blurring the picture, including problems in the conceptualization and measurement of aggression in young people, the lack of prospective designs and the bias towards clinical samples of boys. Research needs to account for variance in the both motivation for and implementation of aggression, and look to the behavioural economics literature to consider the roles of reward, vengeance and self-control more clearly.• Central nervous serotonin (5-HT) function plays a complex and nonlinear role in child and adolescent aggression, with evidence indicating a role for low-expression of 5-HT as well as a role for increased central nervous availability of 5-HT.• Low central nervous 5-HT function may play a role in impulsive implementation of aggression, and increased 5-HT availability may play a role in deliberate, planned implementation and/or in callousunemotional traits that enable aggression for some children and adolescents.

show abstract

Platelet monoamine oxidase activity and temperament and personality in adolescent female substance abusers

Cited by 5 publications

References 38 publications

Neurobiological Processes in Adolescent Addictive Disorders

Neurobiological Processes in Adolescent Addictive Disorders

Executive functioning, temperament, and drug use involvement in adolescent females with a substance use disorder

Serotonin and aggressive behaviour in children and adolescents: a systematic review

Contact Info

Product

Resources

About