Mono(2-ethylhexyl)phthalate exhibits genotoxic effects in human lymphocytes and mucosal cells of the upper aerodigestive tract in the comet assay

Oxidative DNA damage induced by di-(2-ethylhexyl) phthalate in HEK-293 cell line

“…DEHP has been reported to have cytotoxic, immunotoxic, genotoxic, and reproductive toxic properties (Yokoyama et al, 2003;Seo et al, 2004;Svechnikova et al, 2007;Kleinsasser et al, 2004;Duty et al, 2003;), and in long-term feed toxicological studies it has been shown to be carcinogenic in mice and rats (Cattley et al, 1987;National Toxicology Program, 1982). In addition, DEHP and MEHP have been shown to cause the oxidative stress and subsequent DNA damage in many species and cells (Seo et al, 2004;Yang et al, 2012;Hauser et al, 2007).…”

Migration resistant polymeric plasticizer for poly(vinyl chloride)

“…The loss of plasticizer causes changes in the long-term properties of the material as well as possible toxic and biological effects when the plasticizer is transferred to humans. [3][4][5][6] In July 2005, the European Parliament approved the recommendation of a ban forbidding the use of three of the most common phthalate esters, bis(2-ethyl hexyl)phthalate (DEHP), dibutyl phthalate (DBP), and benzyl butyl phthalate (BBP), in toys and childcare articles, within the European Union. 7 The ban also includes the use of three other phthalate esters, diisononyl phthalate (DINP), diisodecyl phthalate (DIDP), and di-n-octyl phthalate (DnOP), in toys and childcare articles that can be placed in the mouth.…”

DEHP: Genotoxicity and potential carcinogenic mechanisms—A review

“…Comet assay in lymphocytes, leukocytes, HepG2, or HeLa cell lines[13,38,106,153]. $1-10 mg/ml DEHP, $30 mg/ml MEHP DNA elution assays and UDS in male mouse primary hepatocytes[181].…”