DEHP: Genotoxicity and potential carcinogenic mechanisms—A review

Caldwell, Jane C.

doi:10.1016/j.mrrev.2012.03.001

Cited by 193 publications

(110 citation statements)

References 172 publications

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“…The annual PAE production is in the range of 5-8 million tons (Mackintosh et al, 2006;Net et al, 2015). Several studies of potential adverse health effects of PAE suggest an endocrinedisrupting activity (Caldwell, 2012). PAE are not covalently bound to polymers, and can easily migrate into the environment during manufacturing, use and disposal of plastics (Staples et al, 1997;Mersiowsky et al, 2001;Fujii et al, 2003;Afshari et al, 2004).…”

Section: Introductionmentioning

confidence: 99%

An unusual strategy for the anoxic biodegradation of phthalate

et al. 2016

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In the past two decades, the study of oxygen-independent degradation of widely abundant aromatic compounds in anaerobic bacteria has revealed numerous unprecedented enzymatic principles. Surprisingly, the organisms, metabolites and enzymes involved in the degradation of o-phthalate (1,2-dicarboxybenzene), mainly derived from phthalate esters that are annually produced at the million ton scale, are sparsely known. Here, we demonstrate a previously unknown capacity of complete phthalate degradation in established aromatic compound-degrading, denitrifying model organisms of the genera Thauera, Azoarcus and 'Aromatoleum'. Differential proteome analyses revealed phthalate-induced gene clusters involved in uptake and conversion of phthalate to the central intermediate benzoyl-CoA. Enzyme assays provided in vitro evidence for the formation of phthaloyl-CoA by a succinyl-CoA-and phthalate-specific CoA transferase, which is essential for the subsequent oxygen-sensitive decarboxylation to benzoyl-CoA. The extreme instability of the phthaloyl-CoA intermediate requires highly balanced CoA transferase and decarboxylase activities to avoid its cellular accumulation. Phylogenetic analysis revealed phthaloyl-CoA decarboxylase as a novel member of the UbiD-like, (de)carboxylase enzyme family. Homologs of the encoding gene form a phylogenetic cluster and are found in soil, freshwater and marine bacteria; an ongoing global distribution of a possibly only recently evolved degradation pathway is suggested.

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Section: Introductionmentioning

confidence: 99%

An unusual strategy for the anoxic biodegradation of phthalate

et al. 2016

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“…They can adversely affect the quality of vegetables through disturbing the normal physiological metabolism of plants (Yin et al, 2003). Recent studies also indicated that DEHP could induce cancer through multiple molecular signals such as DNA damage (Caldwell, 2012). Therefore, the safety associated with the reuse of reclaimed water is of fundamental importance, and this calls for an effective water quality assessment for wastewater reclamation.…”

Section: Introductionmentioning

confidence: 99%

Water Quality Assessment for Wastewater Reclamation Using Principal Component Analysis

Hao

2013

J ENV INFORM

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ABSTRACT. The water quality assessment for wastewater reclamation is usually related to many parameters. This would introduce difficulty in objectively and comprehensively evaluating the overall water quality, and affect the water reuse safety. To address this problem, a principal component analysis (PCA) method was employed in this study to identify the components that mainly affect water quality. By examining eleven indices, a large amount of water quality data of four typical wastewater reclamation treatment plants (WRTP) in northern China were collected. The PCA results indicated that four uncorrelated principal components (PC) could represent the majority of water quality information. The first PC was mainly involved with the COD index and the sensory properties of water, including chroma, turbidity, dissolved solids, and total hardness. The second PC included the indices of NH 3 -N, DBP (di-n-butyl phthalate), and DEHP (Di (2-ethylhexyl) phthalate), reflecting the water reuse safety on both human health and ecological environment. The total phosphorus (TP) and iron (Fe) were included in the third PC, while the fourth PC included dissolved oxygen (DO). Based on PCA analysis, a comprehensive score of water quality was also obtained for each WRTP during each representative month, and it was found that the wastewater reclamation process could greatly affect the quality of reclaimed water. These four identified principle components can help evaluate the overall water quality, and much attention should be given to their effective monitoring and control during the operation of WRTP or the selection of appropriate treatment process.

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“…DEHP is a manufactured chemical commonly added to plastics and it is known as a rodent carcinogen. Exposures of humans as well as rodents suggest that DEHP induces cancer through multiple molecular signals, including DNA damage [145]. It has been implicated in the development of male breast cancer and may cause reproductive problems among both men and women who work in PVC fabricating operations [146,147].…”

Section: Phthalatesmentioning

confidence: 99%

Impact of Environmental Contaminants on Breast Cancer / Wpływ Zanieczyszczenia Środowiska Na Raka Piersi

Kráľová

Jampílek

2015

Ecological Chemistry and Engineering S

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Breast cancer is the most frequent cancer in women. It is believed that among the causes of breast cancer, hereditary factors account for only 5-10% of risk and the environmental exposures to environmental contaminants account for an additional 30-50% of risk. This paper summarizes findings related to the risk of breast cancer due to exposure to following environmental contaminants: polycyclic aromatic hydrocarbons, polychlorinated biphenyls and dioxins, organochlorine pesticides, organophosphorous pesticides, bisphenol A, phthalates, parabens, organic solvents, atmospheric pollutants, alkylphenols, metals, ionizing radiation, electromagnetic field and light pollution. Results obtained in in vitro experiments with breast cancer cell lines and in vivo with model rodents as well as in population based case-control studies are presented and the mode of action of individual environmental contaminants on mammary gland is discussed. Attention is also devoted to the effects of the timing of exposure to environmental contaminants (mainly exposition during development of the mammary gland) on breast cancer risk. Outcomes of professional exposure to some environmental contaminants on breast cancer risk are analysed as well.

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DEHP: Genotoxicity and potential carcinogenic mechanisms—A review

Cited by 193 publications

References 172 publications

An unusual strategy for the anoxic biodegradation of phthalate

An unusual strategy for the anoxic biodegradation of phthalate

Water Quality Assessment for Wastewater Reclamation Using Principal Component Analysis

Impact of Environmental Contaminants on Breast Cancer / Wpływ Zanieczyszczenia Środowiska Na Raka Piersi

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