Molybdenum in human whole blood of adult residents of the Merida State (Venezuela)

Burguera, J.L.; Burguera, M.

doi:10.1016/j.jtemb.2007.03.005

Cited by 31 publications

(9 citation statements)

References 15 publications

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“…The values of whole blood Mo in German [25] and British [5] subjects were similar and also similar to the values of serum Mo; however, the Mo concentration of whole blood from Venezuelan subjects [26] was obviously higher than those of European subjects. The Venezuelan study used the AAS method while the two European studies used the ICP-MS technique for Mo determination; however, since the dietary pattern and Mo intake of Venezuelan people are unclear, it cannot be concluded that differences in the analytical method influence the analytical values of whole blood Mo concentration.…”

Section: Molybdenum In Bloodsupporting

confidence: 63%

Molybdenum in Biological Samples and Clinical Significance of Serum Molybdenum

Yoshida

2012

Analytical Techniques for Clinical Chemistry

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Section: Molybdenum In Bloodsupporting

confidence: 63%

Molybdenum in Biological Samples and Clinical Significance of Serum Molybdenum

Yoshida

2012

Analytical Techniques for Clinical Chemistry

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“…In living organisms, molybdenum is present at low concentrations. In humans, highest Mo levels are found in kidney, liver, small intestine, and adrenals [ 1 ]. In serum, the concentration is about 0.6 ng mL -1 [ 2 ], but depends on dietary intake [ 3 ].…”

Section: Chemistry and Biology Of Molybdenummentioning

confidence: 99%

Molybdenum in Human Health and Disease

Schwarz

Belaidi

2013

Metal Ions in Life Sciences

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Molybdenum is an essential trace element and crucial for the survival of animals. Four mammalian Mo-dependent enzymes are known, all of them harboring a pterin-based molybdenum cofactor (Moco) in their active site. In these enzymes, molybdenum catalyzes oxygen transfer reactions from or to substrates using water as oxygen donor or acceptor. Molybdenum shuttles between two oxidation states, Mo(IV) and Mo(VI). Following substrate reduction or oxidation, electrons are subsequently shuttled by either inter- or intra-molecular electron transfer chains involving prosthetic groups such as heme or iron-sulfur clusters. In all organisms studied so far, Moco is synthesized by a highly conserved multi-step biosynthetic pathway. A deficiency in the biosynthesis of Moco results in a pleitropic loss of all four human Mo-enzyme activities and in most cases in early childhood death. In this review we first introduce general aspects of molybdenum biochemistry before we focus on the functions and deficiencies of two Mo-enzymes, xanthine dehydrogenase and sulfite oxidase, caused either by deficiency of the apo-protein or a pleiotropic loss of Moco due to a genetic defect in its biosynthesis. The underlying molecular basis of Moco deficiency, possible treatment options and links to other diseases, such as neuropsychiatric disorders, will be discussed.

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“…Two of these molybdoenzymes, xanthine oxidase and aldehyde oxidase, are important to humans. In addition, sulfite oxidase is an indispensable enzyme that contains Mo [1][2][3]. Molybdenum (VI) complexes have been reported as effective antidiabetic agents [4].…”

Section: Introductionmentioning

confidence: 99%

“…Its poisoning mechanism/s, however, is virtually unknown. Excessive dietary intake of molybdenum-rich grains, seeds, and legumes could cause Mo deposits in soft tissues and joints triggering arthritic symptoms [1]. Furthermore, it has been documented that molybdenum poisoning causes severe gastrointestinal irritation with diarrhea, coma ruminants, and death from cardiac failure [9].…”

Section: Introductionmentioning

confidence: 99%

Effect of Molybdenum Nanoparticles on Blood Cells, Liver Enzymes, and Sexual Hormones in Male Rats

Asadi

Mohseni

Noshahr

et al. 2016

Biol Trace Elem Res

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Despite an increasing surge in application of nanoparticles in industries, there is a serious lack of information concerning their impact on human health and the environment. The present study investigated effects of molybdenum nanoparticles (Mo NPs) injected intraperitoneally into Sprague-Dawley rats at different doses of Mo NPs (5, 10, and 15 mg/kg BW per day) during a period of 28 days. Hematological and biochemical parameters as well as sexual hormones and histopathological examinations of the liver and testis were assessed and compared with control group. The results showed that the serum levels of testosterone decreased significantly in both groups of 10 and 15 mg (Mo NPs)/kg BW in comparison with the control group (p < 0.05). However, there were insignificant differences observed in luteinizing hormone (LH) levels and hematological parameters when compared with the control group (p > 0.05). The results of liver enzymes showed that serum levels of aspartate aminotransferase (AST) decreased significantly in both dosage groups of 5 and 10 mg/kg BW (Mo NPs) when compared with the control group (p < 0.05), and significant decrease obtained in lactate dehydrogenase (LDH) levels at dose of 5 mg/kg BW in comparison with the control group (p < 0.05). The histopathological examination of testis showed a decrease in number of Leydig cells. Also, the number of chronic inflammatory cells increased in portal triad and parenchyma in liver tissue of rats exposed to Mo NPs.

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Molybdenum in human whole blood of adult residents of the Merida State (Venezuela)

Cited by 31 publications

References 15 publications

Molybdenum in Biological Samples and Clinical Significance of Serum Molybdenum

Molybdenum in Biological Samples and Clinical Significance of Serum Molybdenum

Molybdenum in Human Health and Disease

Effect of Molybdenum Nanoparticles on Blood Cells, Liver Enzymes, and Sexual Hormones in Male Rats

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