Highlights d Dimedone Switch method is a versatile, chemoselective persulfide labeling approach d Protein persulfidation is an evolutionarily conserved modification of cysteine thiols d Persulfidation waves rescue cysteines from overoxidation caused by ROS d Persulfidation decreases with aging, increases with caloric restriction, and extends lifespan
As a result of an author oversight in the originally published version of this article, the surname of author Bruno Gonzalez-Zorn was misspelled as ''Gonzales-Zorn.'' Additionally, the scheme in the Graphical Abstract contains a final product of proteinS -Sdimedone, rather than proteinS -dimedone. These errors have now been corrected in the article online. The authors apologize for the errors and any inconvenience that may have resulted.
The new-ray burst (GRB) mission Swift has obtained pointed observations of several classical novae in outburst. We analyzed all the observations of classical novae from the Swift archive up to 2006 June 30. We analyzed usable observations of 12 classical novae and found 4 nondetections, 3 weak sources, and 5 strong sources. This includes detections of two novae exhibiting spectra resembling those of supersoft X-ray binary source spectra (SSS), implying ongoing nuclear burning on the white dwarf surface. With these new Swift data, we add to the growing statistics of the X-ray duration and characteristics of classical novae.
Substitution therapies for orphan genetic diseases, including enzyme replacement methods, are frequently hampered by the limited availability of the required therapeutic substance. We describe the isolation of a pterin intermediate from bacteria that was successfully used for the therapy of a hitherto incurable and lethal disease. Molybdenum cofactor (Moco) deficiency is a pleiotropic genetic disorder characterized by the loss of the molybdenum-dependent enzymes sulphite oxidase, xanthine oxidoreductase and aldehyde oxidase due to mutations in Moco biosynthesis genes. An intermediate of this pathway-'precursor Z'-is more stable than the cofactor itself and has an identical structure in all phyla. Thus, it was overproduced in the bacterium Escherichia coli, purified and used to inject precursor Z-deficient knockout mice that display a phenotype which resembles that of the human deficiency state. Precursor Z-substituted mice reach adulthood and fertility. Biochemical analyses further suggest that the described treatment can lead to the alleviation of most symptoms associated with human Moco deficiency.
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