Molecularly Imprinted Sol-Gel Materials for Medical Applications

Abstract

The present review deals with the sol-gel imprinting of both drug and non-drug templates of medical relevance, namely neurotransmitters, biomarkers, hormones, proteins and cells. Nearly a hundred recent works, either developmental or applied in a medical-related context, were critically analyzed. It may be concluded that, although research is still at an early stage, the potential of these sol-gel materials was well demonstrated in a few applications of critical interest for medicinal/biomedical science. The vast room left for expansion and improvement envisages a continuously growing interest by researchers in the future, eventually resulting in important medical applications able to enter the professional and consumer medical markets.

Sistemas Nanoestruturados Biofuncionais: Estratégias de Síntese, Tecnologias e Aplicações em Nanomedicina

“…Esse processo constitui um importante meio de preparação de sistemas híbridos nanoestruturados, em que espécies orgânicas ou biológicas instáveis podem ser adicionadas 37 . Em particular, biomoléculas ou células podem ser incorporadas às nanopartículas que, apresentando tamanhos e funcionalidade adequada, permitam a obtenção de dispositivos biomédicos para diferentes aplicações [38][39][40] . As principais vantagens da técnica sol-gel se devem à baixa temperatura de processamento, versatilidade e reologia flexível, permitindo fácil modelagem e incorporação de bioativos.…”

Synergistic effect of silane cross-linker (APTEOS) on PVA/gelatin blend films for packaging applications

“…41 The amine functionality of APTEOS can be employed to immobilize polymers and also promote cell adhesion. 42 Hence, APTEOS can also be used to strengthen the interface between inorganic phase and polymer in composite films. 43 APTEOS can be hydrolyzed in aqueous environment to form silanol, which react with hydroxyl group on particle surface.…”