New materials for sample preparation techniques in bioanalysis

Nazário, Carlos Eduardo Domingues; Fumes, Bruno Henrique; Silva, Meire Ribeiro da; Lanças, Fernando Mauro

doi:10.1016/j.jchromb.2016.10.041

Cited by 51 publications

(33 citation statements)

References 129 publications

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“…Nowadays a wide variety of phases have been commercialized such as silica, silica bonded with different groups, mixed phases, ion exchange, polymeric phases, and others. Nonetheless, the low efficiency, selectivity and extraction stability of conventional materials is a major limitation, as well as the high commercial cost of these extractive phases . In this way, recent studies have been made to obtain new sorbent materials that can be used as extractive phase in the preparation of samples such as molecularly imprinted polymers (MIP), restricted access media (RAM), ionic liquids (IL), carbonaceous nanomaterials, and combinations that aim to improve the efficiency of extraction, selectivity, and sensitivity of methods.…”

Section: New Materialsmentioning

confidence: 99%

Recent trends in sorption‐based sample preparation and liquid chromatography techniques for food analysis

2018

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The accelerated rising of the world's population increased the consumption of food, thus demanding more rigors in the control of residue and contaminants in food-based products marketed for human consumption. In view of the complexity of most food matrices, including fruits, vegetables, different types of meat, beverages, among others, a sample preparation step is important to provide more reliable results when combined with HPLC separations. An adequate sample preparation step before the chromatographic analysis is mandatory in obtaining higher precision and accuracy in order to improve the extraction of the target analytes, one of the priorities in analytical chemistry. The recent discovery of new materials such as ionic liquids, graphene-derived materials, molecularly imprinted polymers, restricted access media, magnetic nanoparticles, and carbonaceous nanomaterials, provided high sensitivity and selectivity results in an extensive variety of applications. These materials, as well as their several possible combinations, have been demonstrated to be highly appropriate for the extraction of different analytes in complex samples such as food products. The main characteristics and application of these new materials in food analysis will be presented and discussed in this paper. Another topic discussed in this review covers the main advantages and limitations of sample preparation microtechniques, as well as their off-line and on-line combination with HPLC for food analysis.

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Section: New Materialsmentioning

confidence: 99%

Recent trends in sorption‐based sample preparation and liquid chromatography techniques for food analysis

2018

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“…Graphene oxide is a single-atomic-layered material which made of carbon, hydrogen, and oxygen molecules as a result of graphite crystals oxidation which is low-cost and plentiful [15]. GO includes many functional groups such as epoxy (-O), hydroxyl (OH), and carboxyl (-COOH) on the basal planes of GO [16]. These functional groups are sensitive sites for physical-chemical bonding with polymers and modify the Van der Waals connections among the nanofiller.…”

Section: ■ Introductionmentioning

confidence: 99%

Alginate-Graphene Oxide Biocomposite Sorbent for Rapid and Selective Extraction of Non-Steroidal Anti-Inflammatory Drugs Using Micro-Solid Phase Extraction

et al. 2019

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In this work, a bio-composite sorbent, alginate incorporated graphene oxide (Alg/GO) is prepared for the micro solid phase extraction of non-steroidal anti-inflammatory drugs (NSAIDs) from water samples. The sorbent was prepared in a suspended solution form at a ratio of 0.3:1 (w/v %) of graphene oxide (GO) and alginate (Alg). The chemical structure, morphology and surface area of the composite beads were characterized using Fourier Transform Infrared Spectroscopy (FT-IR), Scanning Electron Microscopy (SEM) and Brunauer–Emmett–Teller (BET). GO showed good miscibility and well dispersion through intermolecular hydrogen bonds and electrostatic interactions within the Alg matrix. The synthesized sorbent was applied for the determination of the selected drugs in a tap water sample using micro-solid phase extraction technique and was analyzed by high-performance liquid chromatography-ultraviolet detector (HPLC-UV). The results showed good linearity in the range of 10–1000 µg L–1 with correlation coefficients (r ≥ 0.9979), low detection limits (LOD) between 3.1–4.6 µg L–1, excellent relative recoveries in the range of 99.6–102.1% and good reproducibility (RSD ≤ 3.9%). Thus, these validated results showed that Alg/GO could be potential and useful as a bio-composite sorbent for micro-solid phase extraction for the analysis of targeted drugs from aqueous matrices.

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“…Then, sample preparation techniques are required to reduce the matrix effects and concentrate target compounds. To improve the sample preparation step and make it more efficient than the traditional procedures, microextraction techniques were developed including SPME, SBSE, LPME, MEPS .…”

Section: Introductionmentioning

confidence: 99%

Graphene particles supported on silica as sorbent for residue analysis of tetracyclines in milk employing microextraction by packed sorbent

et al. 2018

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This paper describes the use of graphene-based sorbents for determination of four tetracyclines in milk. The synthesized materials were combined with microextraction by packed sorbent (MEPS) to act as the sample preparation step. The extraction performance of these sorbents was compared to commercial phases, and graphene supported on silica provided the best results. The analytical method optimization was carried out by employing experimental design. Firstly, an evaluation of the experimental variables (elution solvent, use of EDTA, ionic force, and pH of the washing solution) was made by a 2 factorial experimental design. The variables sampling, washing and elution cycles of MEPS were further optimized under a full 2 experimental design. The validation parameters were determined under optimized conditions resulting in a linearity ranging from 15 to 110 μg/L with R values above 0.98, and LOQs ranging from 0.05 to 0.9 μg/L. The accuracy ranged from 87.9 to 118.4% and intra/inter-day precision reported by the RSDs were lower than 19%. The proposed and validated method was successfully applied to the analysis of 11 milk samples from different animals, revealing traces of tetracyclines in only two of them. This study focused on the evaluation of graphene-based sorbents combined with MEPS for tetracycline analysis provided equivalent or even better results than other proposed methods, suggesting being a sensitive, fast and reliable alternative method for the determination of tetracyclines in milk samples.

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New materials for sample preparation techniques in bioanalysis

Cited by 51 publications

References 129 publications

Recent trends in sorption‐based sample preparation and liquid chromatography techniques for food analysis

Recent trends in sorption‐based sample preparation and liquid chromatography techniques for food analysis

Alginate-Graphene Oxide Biocomposite Sorbent for Rapid and Selective Extraction of Non-Steroidal Anti-Inflammatory Drugs Using Micro-Solid Phase Extraction

Graphene particles supported on silica as sorbent for residue analysis of tetracyclines in milk employing microextraction by packed sorbent

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