Molecular Approaches for Diagnosis, Therapy and Prevention of Cow’s Milk Allergy

Linhart, Birgit; Freidl, Raphaela; Elisyutina, O G; Khaitov, Musa; Karaulov, Alexander; Valenta, Rudolf

doi:10.3390/nu11071492

Cited by 41 publications

(36 citation statements)

References 173 publications

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“…In the later, antigens in cow's milk were identified [ 135 ]. Recently, several approaches were found to prevent and treat milk allergy [ 136 , 137 ]. The notion of lactose intolerance can date back to the mid-twentieth century when the severe lactose intolerance in infancy was found [ 138 ].…”

Section: Discussionmentioning

confidence: 99%

Milk consumption and multiple health outcomes: umbrella review of systematic reviews and meta-analyses in humans

Zhang

Chen

et al. 2021

Nutr Metab (Lond)

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In order to recapitulate the best available evidence of milk consumption and multiple health-related outcomes, we performed an umbrella review of meta-analyses and systematic reviews in humans. Totally, 41 meta-analyses with 45 unique health outcomes were included. Milk consumption was more often related to benefits than harm to a sequence of health-related outcomes. Dose–response analyses indicated that an increment of 200 ml (approximately 1 cup) milk intake per day was associated with a lower risk of cardiovascular disease, stroke, hypertension, colorectal cancer, metabolic syndrome, obesity and osteoporosis. Beneficial associations were also found for type 2 diabetes mellitus and Alzheimer's disease. Conversely, milk intake might be associated with higher risk of prostate cancer, Parkinson’s disease, acne and Fe-deficiency anaemia in infancy. Potential allergy or lactose intolerance need for caution. Milk consumption does more good than harm for human health in this umbrella review. Our results support milk consumption as part of a healthy diet. More well-designed randomized controlled trials are warranted.

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Section: Discussionmentioning

confidence: 99%

Milk consumption and multiple health outcomes: umbrella review of systematic reviews and meta-analyses in humans

Zhang

Chen

et al. 2021

Nutr Metab (Lond)

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“…Sometimes, complex and systematic anaphylactic response can be observed due to involvement of one or more target organs [21,22]. Different standard gold diagnosis methods for CMA are available such as the double-blind, placebo-controlled oral food challenge (DBPCFC) and unblinded oral food challenge (OFC) [23]. Besides less rigoristic nature and validation of OFC tests, both tests suffer from several limitations in terms of inherent risk of anaphylaxis, time-/resource-intensive nature, inappropriate for clinical practice (especially in large epidemiologic studies), and also safety concerns in atopic children.…”

Section: Number Of Amino Acids/moleculesmentioning

confidence: 99%

Nano-Biosensing Platforms for Detection of Cow’s Milk Allergens: An Overview

Nehra

Lettieri

Dilbaghi

et al. 2019

Sensors

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Among prevalent food allergies, cow milk allergy (CMA) is most common and may persist throughout the life. The allergic individuals are exposed to a constant threat due to milk proteins’ presence in uncounted food products like yogurt, cheese, and bakery items. The problem can be more severe due to cross-reactivity of the milk allergens in the food products due to homologous milk proteins of diverse species. This problem can be overcome by proper and reliable food labeling in order to ensure the life quality of allergic persons. Therefore, highly sensitive and accurate analytical techniques should be developed to detect the food allergens. Here, significant research advances in biosensors (specifically immunosensors and aptasensors) are reviewed for detection of the milk allergens. Different allergic proteins of cow milk are described here along with the analytical standard methods for their detection. Additionally, the commercial status of biosensors is also discussed in comparison to conventional techniques like enzyme-linked immunosorbent assay (ELISA). The development of novel biosensing mechanisms/kits for milk allergens detection is imperative from the perspective of enforcement of labeling regulations and directives keeping in view the sensitive individuals.

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“…Proper diagnosis and allergy management in early childhood is provided in the Diagnosis and Rationale for Action against cow’s milk allergy (CMA) (DRACMA) guidelines [3]. Extensively hydrolyzed milk formulas and amino acid formulas are often used to treat CMA in infants [4]. In the Middle East, the use of partial hydrolysates as an intermediate, first step-down from the use of intact cow’s milk formulas before introducing extensively hydrolyzed or amino acid formulas was recently discussed and approved during a consensus meeting [5].…”

Section: Cow’s Milk Allergymentioning

confidence: 99%

“…In addition to CMA treatment—which in essence is the avoidance of ingestion of intact cow’s milk allergens—there is an urgent need to accelerate immunological tolerance to cow’s milk in these children. Recent progress in the understanding of the immunological basis of tolerance induction can aid in this development of novel sustainable therapies [4,6].…”

Section: Cow’s Milk Allergymentioning

confidence: 99%

“…Thus, different and novel diagnostic tests are needed to characterize the sensitization patterns of patients with different clinical pictures of CMA. Such tests comprise multiplex assays using purified (recombinant) allergen molecules as allergen arrays [4] to detect all potentially clinically relevant allergens and functional basophil activation tests to correlate to the severity of the allergic symptoms [9].…”

Section: Cow’s Milk Allergymentioning

confidence: 99%

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The Two Faces of Cow’s Milk and Allergy: Induction of Cow’s Milk Allergy vs. Prevention of Asthma

Neerven

Savelkoul

2019

Nutrients

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Cow’s milk has been consumed by humans for over 5000 years and contributed to a drastic change in lifestyle form nomadic to settled communities. As the composition of cow’s milk is relatively comparable to breast milk, it has for a very long time been used as an alternative to breastfeeding. Today, cow’s milk is typically introduced into the diet of infants around 6 months, except when breastfeeding is not an option. In that case, most often cow’s milk based infant formulas are given. Some children will develop cow’s milk allergy (CMA) during the first year of life. However, epidemiological evidence also suggests that consumption of unprocessed, “raw” cow’s milk is associated with a lowered prevalence of other allergies. This Special Issue of Nutrients on “Cow’s Milk and Allergy” (https://www.mdpi.com/journal/nutrients/special_issues/milk_allergy) is dedicated to these two different sides of cow’s milk and allergy, ranging from epidemiology of CMA, clinical presentation and sensitization patterns, treatment and prevention, effects of milk processing, and current management guidelines for CMA, but also the epidemiological evidence linking cow’s milk to lower asthma prevalence as well as the tolerance-inducing effect of raw cow’s milk in food allergy models. In this editorial, we discuss these issues by highlighting the contributions in this Special Issue.

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Molecular Approaches for Diagnosis, Therapy and Prevention of Cow’s Milk Allergy

Cited by 41 publications

References 173 publications

Milk consumption and multiple health outcomes: umbrella review of systematic reviews and meta-analyses in humans

Milk consumption and multiple health outcomes: umbrella review of systematic reviews and meta-analyses in humans

Nano-Biosensing Platforms for Detection of Cow’s Milk Allergens: An Overview

The Two Faces of Cow’s Milk and Allergy: Induction of Cow’s Milk Allergy vs. Prevention of Asthma

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