The Two Faces of Cow’s Milk and Allergy: Induction of Cow’s Milk Allergy vs. Prevention of Asthma

Neerven, R. J. Joost van; Savelkoul, H.F.J.

doi:10.3390/nu11081945

Cited by 10 publications

(5 citation statements)

References 32 publications

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“…However, the JECS data suggested an association between early formula milk intake and a reduced risk of cow's milk allergy [36]. Additionally, drinking cow's milk might be associated with a higher risk of developing allergies [37,38]. If the family business is related to milk consumption, the present results may have been affected by the children's amount of milk consumption.…”

Section: Discussionmentioning

confidence: 55%

High Incidence of Atopic Dermatitis among Children Whose Fathers Work in Primary Industry: The Japan Environment and Children’s Study (JECS)

Yokomichi

Mochizuki

Kojima

et al. 2022

IJERPH

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The hygiene hypothesis assumes a low incidence of allergic diseases in families engaging in farming work. However, a few studies have indicated rural life as a potential risk factor for atopic dermatitis (AD). Using a large Japanese birth cohort dataset, we calculated the accumulated incidence of AD in children aged 6 months and 1, 2, and 3 years by family business and the hazard ratio. We adjusted for confounding factors. The father’s job was considered the family business. We analysed data on 41,469 father–child pairs at 6 months of age, 40,067 pairs at 1 year, 38,286 pairs at 2 years, and 36,570 pairs at 3 years. We found the highest accumulated incidence of AD among children with fathers engaged in primary industry, with 2.5% at the age of 6 months, 6.6% at 1 year, 12.0% at 2 years, and 15.4% at 3 years. Among primary industry occupations, forestry was associated with the highest incidence of AD across these ages. The hazard ratio of AD was also highest for children whose family business was primary industry. In conclusion, the highest incidence and hazard ratio of AD were observed among children whose fathers worked in primary industry.

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Section: Discussionmentioning

confidence: 55%

High Incidence of Atopic Dermatitis among Children Whose Fathers Work in Primary Industry: The Japan Environment and Children’s Study (JECS)

Yokomichi

Mochizuki

Kojima

et al. 2022

IJERPH

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“…According to van Neerven, et al (2019), cow's milk allergy in children will primarily result in excessive allergies and immunological tolerance to cow's milk before the age of three to four years. 23 Some data suggests that allergies may play a key role in children with severe asthma, according to Arasi, et al (2019). 24 Many children with severe asthma also have an allergic disease.…”

Section: Discussionmentioning

confidence: 99%

Asthma Exacerbation during the COVID-19 Pandemic

Sawitri,

Roosihermiatie,

Adji

et al. 2023

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Introduction: Asthmatics, especially uncontrolled asthmatics, must be vigilant during the COVID-19 pandemic to avoid major respiratory complications. This study aimed to describe these characteristics in emergency unit patients with asthma and COVID-19 at Haji General Hospital, Surabaya, an East Java referral hospital. Methods: The study gathered medical information on 160 asthma patients from March to December 2021. The collected data were related to socioeconomics, allergy history, family allergy history, and medications. Results: 160 confirmed cases of asthma occurred during COVID-19 at Haji General Hospital, Surabaya. Most adult asthma sufferers were women (59.2%), high school graduates (31.25%), housewives (21.2%), had payment method with Social Health Insurance Administration Body (BPJS) insurance (73.8 %), had a history of drug allergies (11.5%), had no family history of allergies (50.8%), and used albuterol control drugs (10.7%). Meanwhile, the majority of children with asthma were boys (53.3%), did not attend school or did not finish elementary school (33.3%), did not work (33.3%), had payment method with BPJS (73.3%), had a history of allergies to seafood and cow's milk respectively (10%), had no family history of allergies (40%), and used albuterol control drugs (16.7%). Conclusion: The proportion of asthma in the emergency unit was dominated by women over 18 years old with a high school education. Most patients were housewives and used BPJS. Many of them had a history of allergies to medications (not asthma medication), and there was no family history of allergies. Commonly used medications were albuterol to control asthma.

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“…Investigating the mechanisms underlying asthma tolerance is beneficial to exploit new targets to induce stable tolerance and prevent asthma and allergic disease. More than 15 epidemiological studies so far have shown that raw cow milk can reduce the risk of allergic diseases, confirming the tolerance‐inducing effect of intestinal exposure to antigens 5–8 . Based on the classic model of breast milk‐transferred asthma tolerance, 9,10 our previous studies successfully established a mouse model of asthma tolerance by directly feeding ovalbumin (OVA) in early life 11 .…”

Section: Introductionmentioning

confidence: 91%

Vagal‐α7nAChR signaling attenuates allergic asthma responses and facilitates asthma tolerance by regulating inflammatory group 2 innate lymphoid cells

Feng

et al. 2020

Immunol. Cell Biol.

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Disorders of immune tolerance may lead to allergic asthma. Group 2 innate lymphoid cells (ILC2s) and inflammatory ILC2s (iILC2s) are key players in asthma. The vagus nerve innervating the airways releases acetylcholine or neuropeptides (i.e. calcitonin gene‐related peptide) via pulmonary C‐fibers (PCFs), which could regulate ILC2 activity upon binding the α7 nicotinic acetylcholine receptor (α7nAChR, coded by Chrna7) or neuropeptide receptors. Whether and how α7nAChR and PCFs regulate asthma and the formation of asthma tolerance via ILC2s or iILC2s are poorly understood. We used vagotomized, PCF degeneration and Chrna7 knockout mice to investigate ovalbumin (OVA)‐induced asthma and oral OVA feeding‐induced asthma tolerance. Our results revealed that vagotomy could generally suppress lung ILC2s and iILC2s, which mitigated allergic asthma responses but disrupted asthmatic tolerance. Removal of neuropeptides by PCF degeneration also reduced lung ILC2s and iILC2s, attenuating asthma responses, but did not affect asthma tolerance. In comparison, deletion of Chrna7 increased resident ILC2s and trafficking iILC2s in the lung, worsened allergic inflammation and disrupted oral tolerance. Mechanistically, deletion of Chrna7 in asthma‐tolerant conditions upregulated T helper 2 cytokine‐ (Il4, Il13 and Il25) and sphingosine‐1‐phosphate (S1P)‐related genes (S1pr1 and Sphk1). Blockade of S1P reduced iILC2 recruitment into asthmatic lungs. Our work is the first to demonstrate that vagal‐α7nAChR signaling engaging with iILC2s and S1P not only alleviates asthma but also facilitates asthma tolerance. These findings may provide a novel therapeutic target for attenuating asthma by enhancing asthmatic tolerance.

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The Two Faces of Cow’s Milk and Allergy: Induction of Cow’s Milk Allergy vs. Prevention of Asthma

Cited by 10 publications

References 32 publications

High Incidence of Atopic Dermatitis among Children Whose Fathers Work in Primary Industry: The Japan Environment and Children’s Study (JECS)

High Incidence of Atopic Dermatitis among Children Whose Fathers Work in Primary Industry: The Japan Environment and Children’s Study (JECS)

Asthma Exacerbation during the COVID-19 Pandemic

Vagal‐α7nAChR signaling attenuates allergic asthma responses and facilitates asthma tolerance by regulating inflammatory group 2 innate lymphoid cells

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