Modulatory effect of berberine on adipose tissue PPARγ, adipocytokines and oxidative stress in high fat diet/ streptozotocin-induced diabetic rats

doi:10.7324/japs.2017.70401

Cited by 9 publications

(8 citation statements)

References 34 publications

(41 reference statements)

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“…Thus, Ber promoted IVM of porcine oocytes and the development of IVF embryos. Studies have shown that feeding Ber to obese rats decreased transcription of PPARG in the adipose tissue of rats (Ayman et al, 2017) and decreased phosphorylation of JNK in ileal cells of rats (Cui et al, 2018), which is consistent with our results.…”

Section: Discussionsupporting

confidence: 93%

Mechanisms of lipid metabolism promoted by berberine via peroxisome proliferator‐activated receptor gamma during in vitro maturation of porcine oocytes

Dai

Huang

Zhang

et al. 2021

Animal Science Journal

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This study was conducted to explore the molecular mechanisms of berberine (Ber) via peroxisome proliferator-activated receptor gamma (PPARG) in promoting in vitro maturation (IVM) and lipid metabolism of porcine oocytes. Our results showed that expression changes in PPARG influenced IVM and the lipid droplet content of porcine oocytes. Moreover, c-Jun-N-terminal kinase (JNK) inhibitor modified the effect of PPARG agonist on IVM and lipid droplet content of porcine oocytes, and Ber significantly reduced lipid droplet content. Activation of PPARG upregulated the transcription level of , significantly promoted the expression of fatty acid binding protein 3 (FABP3) and steroid regulatory element binding transcription factor 1 (SREBF1) and PPARG, inhibited phosphorylation of PPARG, and enhanced JNK phosphorylation. Ber and overexpression of miR-192 upregulated the transcription level of miR-192 in porcine oocytes; significantly decreased the expression of FABP3, SREBF1, and PPARG; increased PPARG phosphorylation; and inhibited JNK phosphorylation. Otherwise, JNK inhibitor reduced the effects of PPARG agonist. In conclusion, Ber may activate the expression of miR-192, downregulate the expression level of PPARG and lipid synthesis-related genes, increase PPARG phosphorylation, and reduce JNK phosphorylation to enhance lipid metabolism, which is beneficial to improve porcine oocyte quality of IVM.

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Section: Discussionsupporting

confidence: 93%

Mechanisms of lipid metabolism promoted by berberine via peroxisome proliferator‐activated receptor gamma during in vitro maturation of porcine oocytes

Dai

Huang

Zhang

et al. 2021

Animal Science Journal

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“…Improvements in blood glucose levels after the intervention with LVSP and AST also have an impact in improving metabolism, marked by a decrease in the activity of glucose-6-phosphatase and fructose-1-6-bisphosphatase, which participate in glucose formation and decrease gluconeogenesis that has previously occurred in T2DM. The reduction of tissue protein disassembly as a raw material for gluconeogenesis results in improvement of weight gain and insulin sensitivity (Pournaghi et al , 2012; Mahmoud et al , 2017).…”

Section: Discussionmentioning

confidence: 99%

Whiteleg shrimp shell powder ameliorates adiponectin and triglyceride-to-HDL ratio in type 2 diabetic rats

Ayuningtyas

Agustini

Djamiatun

2019

NFS

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Purpose Adiponectin, a bioactive molecule produced by adipose tissue, has potential effect in increasing insulin sensitivity. Adiponectin levels reduction is associated with type 2 diabetes mellitus (T2DM) and its complications, including cardiovascular disease (CVD). Triglyceride-to-high-density lipoprotein (TG:HDL) ratio can be used as a predictor of CVD risk in T2DM patients. Whiteleg shrimp (Litopenaeus vannamei) shell contains astaxanthin, macro- and micro-nutrients that may exert synergistic beneficial effects. This study aims to determine the effect of L. vannamei shell powder (LVSP) in improving adiponectin, TG, HDL and TG:HDL of T2DM Wistar rat, and to investigate the presence of any correlations between adiponectin and lipid markers. Design/methodology/approach A total of 25 male Wistar rats were divided into five equal groups: control negative [C(−)], control positive [C(+)], treatments 1, 2 and 3 (T1, T2 and T3, respectively). C(+), T1, T2 and T3 were maintained on a high-fat diet for 14 days before streptozotocin (STZ) injection. T1 and T2 groups were administered two different doses of LVSP, while T3 group was provided astaxanthin supplement (AST). Findings LVSP treatments significantly increase adiponectin (p = 0.04) and HDL (p < 0.001) but reduced TG (p < 0.001) and TG:HDL (p < 0.001). A higher LVSP dose was more effective in improving all markers than the lower dose; moreover, there was a comparable effect as that of AST in increasing the adiponectin levels. Strong correlations were observed between adiponectin and lipid markers. Originality/value This study shows that LVSP as a functional food, can ameliorate adiponectin levels and normalizes blood glucose levels. The LVSP reduces the risk of CVD because of the reduction of TG:HDL.

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“…Studies have shown an increase in NO levels in patients with diabetes mellitus [ 231 ]. Berberine has been reported to reduce NO levels [ 196 , 205 ]. Under hyperglycemic conditions, NO levels increase through the upregulation of iNOS.…”

Section: Antioxidant Activity Of Berberinementioning

confidence: 99%

A Review of Fibraurea tinctoria and Its Component, Berberine, as an Antidiabetic and Antioxidant

et al. 2023

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Diabetes mellitus is a group of metabolic disorders characterized by hyperglycemia caused by resistance to insulin action, inadequate insulin secretion, or excessive glucagon production. Numerous studies have linked diabetes mellitus and oxidative stress. People with diabetes usually exhibit high oxidative stress due to persistent and chronic hyperglycemia, which impairs the activity of the antioxidant defense system and promotes the formation of free radicals. Recently, several studies have focused on exploring natural antioxidants to improve diabetes mellitus. Fibraurea tinctoria has long been known as the native Borneo used in traditional medicine to treat diabetes. Taxonomically, this plant is part of the Menispermaceae family, widely known for producing various alkaloids. Among them are protoberberine alkaloids such as berberine. Berberine is an isoquinoline alkaloid with many pharmacological activities. Berberine is receiving considerable interest because of its antidiabetic and antioxidant activities, which are based on many biochemical pathways. Therefore, this review explores the pharmacological effects of Fibraurea tinctoria and its active constituent, berberine, against oxidative stress and diabetes, emphasizing its mechanistic aspects. This review also summarizes the pharmacokinetics and toxicity of berberine and in silico studies of berberine in several diseases and its protein targets.

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Modulatory effect of berberine on adipose tissue PPARγ, adipocytokines and oxidative stress in high fat diet/ streptozotocin-induced diabetic rats

Cited by 9 publications

References 34 publications

Mechanisms of lipid metabolism promoted by berberine via peroxisome proliferator‐activated receptor gamma during in vitro maturation of porcine oocytes

Mechanisms of lipid metabolism promoted by berberine via peroxisome proliferator‐activated receptor gamma during in vitro maturation of porcine oocytes

Whiteleg shrimp shell powder ameliorates adiponectin and triglyceride-to-HDL ratio in type 2 diabetic rats

A Review of Fibraurea tinctoria and Its Component, Berberine, as an Antidiabetic and Antioxidant

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